1,2-Hexanediol

ChemicalBook > CAS DataBase List > 1,2-Hexanediol

Product Name: 1,2-Hexanediol
CAS No.: 6920-22-5
Chemical Name: 1,2-Hexanediol
Synonyms: 1,2-HEXANEDIOL;HDO;hexane-1,2-diol;1,2-DIHYDROXYHEXANE;1,2-HEXYLENE GLYCOL;dl-hexane-1,2-diol;DL-1;1,2-hexandiol;1,2 Hexeanediol;DL-1,2-Hexanedio
CBNumber: CB2119791
Molecular Formula: C6H14O2
Formula Weight: 118.17
MOL File: 6920-22-5.mol

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1,2-Hexanediol Property

Melting point:: 45°C
alpha: [α]D20 -0.3～+0.3゜ (neat)
Boiling point:: 223-224 °C (lit.)
Density: 0.951 g/mL at 25 °C (lit.)
vapor pressure: 0.576Pa at 25℃
refractive index: n20/D 1.442(lit.)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 14.49±0.20(Predicted)
form: Liquid
Specific Gravity: 0.951
color: Clear colorless to light yellow
Odor: at 100.00?%. bland
Water Solubility: Miscible with water, lower aliphatic hydrocarbons and fatty acids.
Sensitive: Hygroscopic
BRN: 1719244
InChIKey: FHKSXSQHXQEMOK-UHFFFAOYSA-N
LogP: 0.58 at 25℃
CAS DataBase Reference: 6920-22-5(CAS DataBase Reference)
EPA Substance Registry System: 1,2-Hexanediol (6920-22-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 2
F: 3
TSCA: Yes
HS Code: 29053990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 213691
Product name: 1,2-Hexanediol
Purity: 98%
Packaging: 10g
Price: $32.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 213691
Product name: 1,2-Hexanediol
Purity: 98%
Packaging: 50g
Price: $59.7
Updated: 2024/03/01

TCI Chemical

Product number: H0688
Product name: 1,2-Hexanediol
Purity: >96.0%(GC)
Packaging: 25mL
Price: $37
Updated: 2024/03/01

TCI Chemical

Product number: H0688
Product name: 1,2-Hexanediol
Purity: >96.0%(GC)
Packaging: 100mL
Price: $98
Updated: 2024/03/01

Alfa Aesar

Product number: L06864
Product name: 1,2-Hexanediol, 97%
Packaging: 50g
Price: $57.7
Updated: 2024/03/01

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1,2-Hexanediol Chemical Properties,Usage,Production

Description

1,2-Hexanediol is a linear aliphatic diol with a carbon chain length containing six carbons. It is a synthetic preservative and moisture-binding agent belonging to a class of agents known as higher molecular glycols. It is considered non-sensitizing. It is ideal for use as an emollient, humectant, and wetting agent in cosmetic and skin care products.

Chemical Properties

clear colorless to light yellow liquid.

Uses

DL-1,2-Hexanediol is a solvent used to dissolve other compounds in a formulation. It can be used in the ruthenium-catalyzed synthesis of oxazolidin-2-ones from urea. It can undergo ruthenium-hydride catalyzed dehydrative coupling with anilines to form substituted indole and quinoline products.

Application

In skin care: 1,2-Hexanediol is one of the most multi-functional ingredients in the cosmetic industry. It is used in skin care, hair care as well as beauty products. It is a great emollient as well as a humectant, that is, it preserves hydration on the skin while also softening it.

Preparation

1,2-Hexanediol was synthesized with an overall yield of approximately 45% using a multi-step process that involved a-bromination of caproic acid, followed by hydrolysis to a-hydroxycaproic acid, and concluded with reduction using lithium aluminum hydride. In an alternate method, the organic acid was oxidized with H2O2 to form a peroxy acid, which in turn epoxidized the olefin double bond and ultimately underwent hydrolysis to yield 1,2-hexanediol.
SYNTHESIS OF SOME HEXANEDIOLS

benefits

1,2 hexanediol is most commonly used as a solvent in skincare formulation. It pulls the moisture up from the deeper levels of the skin, as well as from the air, to help keep the top layers of your skin from drying out. This makes It very effective at keeping your skin hydrated and providing long-term moisture. It can also help to disperse pigments more evenly in makeup products and boost the antimicrobial activity of preservatives.

General Description

1,2-Hexanediol acts as cosurfactant, used for modifying the sodium dodecyl sulfate micelles. Solubility of 1,2-hexanediol in supercritical CO₂has been reported. It has a tendency of self-association to form micelle-like aggregates.

Safety

1,2-Hexanediol is safe for skin and hair when used in lower concentrations. In an in-use safety evaluation for skin irritation and sensitization potential, 28 participants (males and females) were instructed to use a body wash containing 0.15% 1,2- hexanediol for a minimum of 3 times per week over a 30-day period. There was no evidence of erythema, edema, or dryness of application sites in any of the participants, and it was concluded that the product did not demonstrate a potential for eliciting skin irritation or sensitization.
Safety Assessment of 1,2-Glycols as Used in Cosmetics

Purification Methods

Fractionally distil it, preferably in a vacuum. Alternatively, dissolve it in Et2O, dry with K2CO3 then Na2SO4, filter, evaporate and distil it in a vacuum. The bis-4-nitrobenzoyl derivative has m 101.5-102.5o. [Rudloff Can J Chem 36 486 1958, Beilstein 1 I 251, 1 III 2200, 1 IV 2554.]

1,2-Hexanediol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,2-Hexanediol manufacturers

HebeiShuoshengImportandExportco.,Ltd

Product: 1,2-Hexanediol 6920-22-5
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-08

HebeiShuoshengImportandExportco.,Ltd

Product: DL-1,2-Hexanediol 6920-22-5
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-08

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 1,2-Hexanediol 6920-22-5
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-04-23

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