2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE
Uses- Product Name
- 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE
- CAS No.
- 875781-44-5
- Chemical Name
- 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE
- Synonyms
- 2-broMo-7-iodo-5H-pyrrolo[2;5-Bromo-3-iodo-4,7-diazaindole;2-bromo-7-iodo-4H-pyrrolo[2,3-b]pyrazine;2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE;5H-Pyrrolo[2,3-b]pyrazine,2-bromo-7-iodo-;2-bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine 2-bromo-7-iodo-5H-pyrrolo[3,2-b]pyrazine
- CBNumber
- CB21215898
- Molecular Formula
- C6H3BrIN3
- Formula Weight
- 323.92
- MOL File
- 875781-44-5.mol
2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE Property
- Boiling point:
- 311℃
- Density
- 2.78
- Flash point:
- 142℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.08±0.50(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B129540
- Product name
- 2-Bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB142358
- Product name
- 2-Bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B12611
- Product name
- 2-Bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine
- Purity
- 95%
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- AK-27489
- Product name
- 5-Bromo-3-iodo-4,7-diazaindole
- Purity
- 95%
- Packaging
- 250mg
- Price
- $30
- Updated
- 2021/12/16
- Product number
- W8988
- Product name
- 5-Bromo-3-iodo-4,7-diazaindole
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE Chemical Properties,Usage,Production
Uses
2-Bromo-7-iodo-5H-pyrrolo[2,3-B]pyrazine is a common pyrrolo[2,3-B]pyrazine bicyclic compound, widely used in the preparation of pharmaceutical and chemical intermediates.
Synthesis
875781-43-4
875781-44-5
Step 1. Synthesis of 2-bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine. To a solution of N,N-dimethylformamide (DMF, 160 mL) of 2-bromo-5H-pyrrolo[2,3-b]pyrazine (8 g, 40.4 mmol) was added N-iodosuccinimide (NIS, 11.8 g, 3.6 mmol) and the reaction mixture was stirred for 1 hour at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether: ethyl acetate = 2:1) to confirm the completion of the reaction. The reaction mixture was diluted with water (500 mL) and extracted with ethyl acetate (EtOAc, 300 mL x 3). The organic phases were combined, washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the solvent was removed by concentration under reduced pressure to afford 2-bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine (26.1 g, 100% yield) as a brown solid (containing a small amount of DMF).
References
[1] Patent: US2015/158864, 2015, A1. Location in patent: Paragraph 0645
[2] Patent: WO2010/15803, 2010, A1. Location in patent: Page/Page column 43
[3] Patent: WO2010/68483, 2010, A2. Location in patent: Page/Page column 68
[4] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 65; 67
[5] Patent: WO2014/85795, 2014, A1. Location in patent: Paragraph 0283
2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE manufacturers
- Product
- 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE 875781-44-5
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12