ChemicalBook > CAS DataBase List > 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE

2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE

Uses

Product Name: 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE
CAS No.: 875781-44-5
Chemical Name: 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE
Synonyms: 2-broMo-7-iodo-5H-pyrrolo[2;5-Bromo-3-iodo-4,7-diazaindole;2-bromo-7-iodo-4H-pyrrolo[2,3-b]pyrazine;2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE;5H-Pyrrolo[2,3-b]pyrazine,2-bromo-7-iodo-;2-bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine 2-bromo-7-iodo-5H-pyrrolo[3,2-b]pyrazine
CBNumber: CB21215898
Molecular Formula: C6H3BrIN3
Formula Weight: 323.92
MOL File: 875781-44-5.mol

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2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE Property

Boiling point:: 311℃
Density: 2.78
Flash point:: 142℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.08±0.50(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B129540
Product name: 2-Bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Ark Pharm

Product number: AK-27489
Product name: 5-Bromo-3-iodo-4,7-diazaindole
Purity: 95%
Packaging: 250mg
Price: $30
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142358
Product name: 2-Bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B12611
Product name: 2-Bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine
Purity: 95%
Packaging: 500mg
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: W8988
Product name: 5-Bromo-3-iodo-4,7-diazaindole
Packaging: 100mg
Price: $105
Updated: 2021/12/16

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2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE Chemical Properties,Usage,Production

Uses

2-Bromo-7-iodo-5H-pyrrolo[2,3-B]pyrazine is a common pyrrolo[2,3-B]pyrazine bicyclic compound, widely used in the preparation of pharmaceutical and chemical intermediates.

Synthesis

875781-43-4

875781-44-5

Step 1. Synthesis of 2-bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine. To a solution of N,N-dimethylformamide (DMF, 160 mL) of 2-bromo-5H-pyrrolo[2,3-b]pyrazine (8 g, 40.4 mmol) was added N-iodosuccinimide (NIS, 11.8 g, 3.6 mmol) and the reaction mixture was stirred for 1 hour at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether: ethyl acetate = 2:1) to confirm the completion of the reaction. The reaction mixture was diluted with water (500 mL) and extracted with ethyl acetate (EtOAc, 300 mL x 3). The organic phases were combined, washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the solvent was removed by concentration under reduced pressure to afford 2-bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine (26.1 g, 100% yield) as a brown solid (containing a small amount of DMF).

References

[1] Patent: US2015/158864, 2015, A1. Location in patent: Paragraph 0645
[2] Patent: WO2010/15803, 2010, A1. Location in patent: Page/Page column 43
[3] Patent: WO2010/68483, 2010, A2. Location in patent: Page/Page column 68
[4] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 65; 67
[5] Patent: WO2014/85795, 2014, A1. Location in patent: Paragraph 0283

2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE Suppliers

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View Lastest Price from 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE manufacturers

Career Henan Chemical Co

Product: 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINE 875781-44-5
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

875781-44-5, 2-BROMO-7-IODO-5H-PYRROLO[2,3-B]PYRAZINERelated Search:

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875781-44-5

C6H3BrIN3

Azaindoles

CHIRAL CHEMICALS