Doxorubicinone
- Product Name
- Doxorubicinone
- CAS No.
- 24385-10-2
- Chemical Name
- Doxorubicinone
- Synonyms
- Ccris 7633;ADRIAMYCINONE;Doxorubicinone;Epirubicin aglycon;adriamycinaglycone;Epirubicin aglycone;Doxorubicin aglycone;Doxorubicinone-13C-D3;D2-N-Nitroso desmethyldoxycycline;Epirubicin Hydrochloride Impurity A
- CBNumber
- CB2121622
- Molecular Formula
- C21H18O9
- Formula Weight
- 414.36
- MOL File
- 24385-10-2.mol
Doxorubicinone Property
- Melting point:
- 223-225°C
- Boiling point:
- 741.2±60.0 °C(Predicted)
- Density
- 1.671±0.06 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer
- solubility
- Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 7.45±0.60(Predicted)
- color
- Red to Very Dark Red
- Stability:
- Light Sensitive
- InChI
- InChI=1S/C21H18O9/c1-30-11-4-2-3-8-14(11)20(28)16-15(17(8)25)18(26)9-5-21(29,12(24)7-22)6-10(23)13(9)19(16)27/h2-4,10,22-23,26-27,29H,5-7H2,1H3/t10-,21-/m0/s1
- InChIKey
- IBZGBXXTIGCACK-CWKPULSASA-N
- SMILES
- C1(OC)=C2C(C(=O)C3=C(C2=O)C(O)=C2C(C[C@@](O)(C(CO)=O)C[C@@H]2O)=C3O)=CC=C1
- CAS DataBase Reference
- 24385-10-2
Safety
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
H340May cause genetic defects
H350May cause cancer
H360May damage fertility or the unborn child
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P311Call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21693
- Product name
- Doxorubicinone
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 21693
- Product name
- Doxorubicinone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- 21693
- Product name
- Doxorubicinone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $601
- Updated
- 2024/03/01
- Product number
- 21693
- Product name
- Doxorubicinone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $1031
- Updated
- 2024/03/01
- Product number
- D559070
- Product name
- Doxorubicinone
- Packaging
- 50mg
- Price
- $1390
- Updated
- 2021/12/16
Doxorubicinone Chemical Properties,Usage,Production
Description
Doxorubicinone is a metabolite of the anthracycline antitumor antibiotic doxorubicin . Doxorubicinone inhibits mitochondrial succinoxidase from bovine heart and reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria in a concentration-dependent manner. Doxorubicinone (40 μM) increases pentose phosphate pathway flux by 45% and reduces activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) by 17 and 60%, respectively, in human erythrocytes. It also induces cytotoxicity in patient-derived ovarian cancer colonies in a concentration-dependent manner.
Chemical Properties
Red Solid
Uses
A metabolite of Doxorubicin (Dx).
Definition
ChEBI: Adriamycinone is a member of tetracenes and a quinone.
General Description
Doxorubicinone (adriamycinone) is an aglycone. It is a metabolite of adriamycin converted in the body, and another metabolite is amycinol [1]. Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis.
References
[1] Emara S, et al. Effect of cyclodextrins on the stability of adriamycin, adriamycinol, adriamycinone and daunomycin. Talanta, 2008; 51: 359-364.
Doxorubicinone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Doxorubicinone manufacturers
- Product
- Doxorubicinone 24385-10-2
- Price
- US $2200.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 5 Kg
- Release date
- 2024-02-02