2-AMINO-5-CHLOROBENZOTHIAZOLE

Product Name: 2-AMINO-5-CHLOROBENZOTHIAZOLE
CAS No.: 20358-00-3
Chemical Name: 2-AMINO-5-CHLOROBENZOTHIAZOLE
Synonyms: ASINEX-REAG BAS 00466316;5-Chlorobenzothiazol-2-amine;2-Amino-5-chlorobenzothiazol;2-Amino-5-chlorobenzthiazole;2-AMINO-5-CHLOROBENZOTHIAZOLE;2-Bromo-11-methoxybenzoicacid;5-chlrobenzo[d]thiazol-2-aMine;2-Benzothiazolamine, 5-chloro-;2-helium-5-hydrobenzophenazole;5-Chloro-2-benzo[d]thiazolamine
CBNumber: CB2124522
Molecular Formula: C7H5ClN2S
Formula Weight: 184.65
MOL File: 20358-00-3.mol

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2-AMINO-5-CHLOROBENZOTHIAZOLE Property

Melting point:: 199.0 to 203.0 °C
Boiling point:: 344.3±34.0 °C(Predicted)
Density: 1.532±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: soluble in Methanol
form: powder to crystal
pka: 3.43±0.10(Predicted)
color: White to Almost white
CAS DataBase Reference: 20358-00-3(CAS DataBase Reference)

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Safety

HS Code: 29342000
Toxicity: mouse,LD50,intravenous,92mg/kg (92mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 486, 1952.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3177
Product name: 2-Amino-5-chlorobenzothiazole
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: A3177
Product name: 2-Amino-5-chlorobenzothiazole
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $158
Updated: 2025/07/31

TRC

Product number: A617698
Product name: 2-Amino-5-chlorobenzothiazole
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 078617
Product name: 2-Amino-5-chlorobenzothiazole
Purity: 95%
Packaging: 250mg
Price: $28
Updated: 2021/12/16

AK Scientific

Product number: J99724
Product name: 2-Amino-5-chlorobenzothiazole
Packaging: 1g
Price: $55
Updated: 2021/12/16

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2-AMINO-5-CHLOROBENZOTHIAZOLE Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow solid

Uses

2-amino-5-chlorobenzothiazole is a heterocyclic compound used in pharmaceutical synthesis and experiments.

Synthesis

333-20-0

108-42-9

20358-00-3

General method: a solution of m-chloroaniline (2 mmol) in acetonitrile (15 ml) was slowly added to a solution of potassium thiocyanate (8 mmol) in acetonitrile (15 ml). Subsequently, 0.06 g (30 mol%) of BF3/SiO2 nanocatalyst was added to the reaction system and the mixture was placed in an ice salt bath and mechanically stirred for 30 min. A solution of bromine (4 mmol, 0.2 ml) in acetonitrile (3 ml) was slowly added through a dropping funnel, and the dropping rate was controlled to ensure that the reaction temperature did not exceed 0 °C. After the addition of the bromine solution, stirring was continued at 0 °C for 60 min, after which the reaction mixture was brought to room temperature and stirred for 4 h. The reaction was carried out by thin layer chromatography (TLC). The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was poured into water and heated to 70 °C on a steam bath followed by thermal filtration to remove the catalyst. The catalyst was washed with acetone and recycled for reuse. The filtrate was neutralized with 10% NaOH solution and the resulting precipitate was collected by filtration, dried and recrystallized from ethanol (10 ml) to give the target product 2-amino-5-chlorobenzothiazole. The structure of the product was confirmed by the following physical and spectral data and compared with known standards. In the case of 6-bromo-1,3-benzothiazol-2-amine (2e): yellow solid; yield = 93%; melting point = 202-204 °C (literature value 203 °C); FT-IR (KBr, cm^-1 ): 3315, 3012, 2835, 1580, 1476, 1261, 920, 742, 512; ^1H NMR (400 MHz, CDCl3, δ ppm): 5.44 (s, 2H, NH2), 7.4-7.5 (d, 2H, Ar-H), 7.71 (s, 1H, Ar-H); ^13C NMR (100 MHz, DMSO-d6, δ ppm): 119, 120.9, 125.15, 126.07, 133.1, 152.15, 167.75.

References

[1] Research on Chemical Intermediates, 2016, vol. 42, # 12, p. 7855 - 7868
[2] Asian Journal of Chemistry, 2011, vol. 23, # 9, p. 3969 - 3974
[3] Patent: WO2012/6068, 2012, A2. Location in patent: Page/Page column 118
[4] European Journal of Medicinal Chemistry, 2013, vol. 67, p. 1 - 13

2-AMINO-5-CHLOROBENZOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-CHLOROBENZOTHIAZOLE Suppliers

Americas 1 Canada 1 China 131 Europe 2 India 2 Japan 1 Russia 2 South Korea 1 Ukraine 1 United Kingdom 6 United States 17 Global 165

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View Lastest Price from 2-AMINO-5-CHLOROBENZOTHIAZOLE manufacturers

Career Henan Chemical Co

Product: 2-AMINO-5-CHLOROBENZOTHIAZOLE 20358-00-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

20358-00-3, 2-AMINO-5-CHLOROBENZOTHIAZOLERelated Search:

2-AMINO-4-CHLOROBENZOTHIAZOLE 5-Amino-2-chlorobenzothiazole 2-AMINO-6-CHLOROBENZOTHIAZOLE 6-Amino-2-chlorobenzothiazole 2-AMINO-4-CHLOROBENZOTHIAZOLE HBR,2-AMINO-4-CHLOROBENZOTHIAZOLE HYDROBROMIDE 2-AMINO-5-CHLOROBENZOTHIAZOLE 2-AMINO-5,6-DICHLOROBENZOTHIAZOLE 2-Benzothiazolamine,5-chloro-4-methyl-(9CI) 5-CHLORO-6-METHYL-BENZOTHIAZOL-2-YLAMINE 5-CHLORO-6-METHOXY-BENZOTHIAZOL-2-YLAMINE 2-Amino-4,5-dichlorobenzothiazole. 2-AMINO-6-CHLOROBENZOTHIAZOLE HYDROCHLORIDE 2-Amino-7-chlorobenzothiazole 2-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)(METHYL)AMINO]ETHYL N-(4-CHLOROPHENYL)CARBAMATE 5-CHLORO-2-HYDRAZINO-4-METHYL-1,3-BENZOTHIAZOLE 4,5-DICHLORO-2-BENZOTHIAZOLEHYDRAZINE 5-CHLORO-N-ETHYL-1,3-BENZOTHIAZOL-2-AMINE 5-CHLORO-2-HYDRAZINO-1,3-BENZOTHIAZOLE

ASINEX-REAG BAS 00466316

5-CHLOROBENZO[D]THIAZOL-2-AMINE

5-CHLORO-1,3-BENZOTHIAZOL-2-AMINE

2-AMINO-5-CHLOROBENZOTHIAZOLE

2-Benzothiazolamine,5-chloro-(9CI)

5-Chlorobenzothiazol-2-amine

5-chlrobenzo[d]thiazol-2-aMine

5-Chloro-benzothiazol-2-ylaMine

5-Chloro-2-benzo[d]thiazolamine

2-Amino-5-chlorobenzthiazole

2-Amino-5-chlorobenzothiazol

2-Benzothiazolamine, 5-chloro-

2-Amino-5-chlorobenzo[d]thiazole

2-Bromo-11-methoxybenzoicacid

2-helium-5-hydrobenzophenazole

20358-00-3

C7H5ClN2S

BENZOTHIAZOLE