METHYL2-AMINO-3-FLUOROBENZOATE
- Product Name
- METHYL2-AMINO-3-FLUOROBENZOATE
- CAS No.
- 144851-82-1
- Chemical Name
- METHYL2-AMINO-3-FLUOROBENZOATE
- Synonyms
- METHYL2-AMINO-3-FLUOROBENZOATE;2-Amino-3-fluorobenzoic acid methyl ester;Benzoic acid, 2-aMino-3-fluoro-, Methyl ester;2-amino-3-fluoro-Benzoic acid methyl ester (9CI ACI);Benzoic acid, 2-amino-3-fluoro-, methyl ester (9CI, ACI)
- CBNumber
- CB21265297
- Molecular Formula
- C8H8FNO2
- Formula Weight
- 169.15
- MOL File
- 144851-82-1.mol
METHYL2-AMINO-3-FLUOROBENZOATE Property
- Boiling point:
- 247℃
- Density
- 1.264
- Flash point:
- 103℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 0.80±0.10(Predicted)
- Appearance
- Yellow to brown Solid
- InChI
- InChI=1S/C8H8FNO2/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4H,10H2,1H3
- InChIKey
- ISLOQGNBENYQQF-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC(F)=C1N
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M328778
- Product name
- Methyl2-amino-3-fluorobenzoate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FM64244
- Product name
- 2-Amino-3-fluorobenzoic acid methyl ester
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- PC53196
- Product name
- Methyl2-amino-3-fluorobenzoate
- Packaging
- 1g
- Price
- $109
- Updated
- 2021/12/16
- Product number
- 4658-3-75
- Product name
- Methyl 2-amino-3-fluorobenzoate
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FM64244
- Product name
- 2-Amino-3-fluorobenzoic acid methyl ester
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
METHYL2-AMINO-3-FLUOROBENZOATE Chemical Properties,Usage,Production
Uses
Methyl 2-amino-3-fluorobenzoate
Synthesis
67-56-1
825-22-9
144851-82-1
General procedure for the synthesis of methyl 2-amino-3-fluorobenzoate from methanol and 2-amino-3-fluorobenzoic acid: 1. a mixture of 2-amino-3-fluorobenzoic acid (559 mg, 3.62 mmol) and 1.7 mL of concentrated H2SO4 in 11 mL of anhydrous methanol was heated and refluxed for 66 hours. 2. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove methanol. 3. The residue was dissolved in 30 mL of water and transferred to a dispensing funnel. 4. Slowly add solid sodium carbonate to neutralize to pH 9-10 until no gas escapes. 5. 5. Extract the aqueous layer with ethyl acetate (3 x 40 mL). 6. The organic layers were combined and washed sequentially with 100 mL of saturated aqueous NaHCO3 and 100 mL of brine. 7. The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. 8. The product was purified by column chromatography (eluent: 5% ethyl acetate in hexane) to give Intermediate 10 (491 mg, 80% yield) as a white solid. 9. 9. Characterization of the product: 1H-NMR (CDCl3, 300 MHz) δ: 7.66-7.63 (m, 1H), 7.15-7.08 (m, 1H), 6.60-6.55 (m, 1H), 5.40 (br s, 2H), 3.89 (s, 3H); LCMS m/z [M+H]+ calculated C8H8FNO2: 170.05, measured value. 170.05, measured value: 170.10.
References
[1] Patent: WO2011/163518, 2011, A1. Location in patent: Page/Page column 158
[2] Patent: US2013/273037, 2013, A1. Location in patent: Paragraph 0808-0811
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 4, p. 1630 - 1643
[4] Patent: WO2009/27730, 2009, A1. Location in patent: Page/Page column 55
[5] Chemical Communications, 2018, vol. 54, # 90, p. 12766 - 12769
METHYL2-AMINO-3-FLUOROBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL2-AMINO-3-FLUOROBENZOATE manufacturers
- Product
- Methyl 2-amino-3-fluorobenzoate 144851-82-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
- Product
- METHYL2-AMINO-3-FLUOROBENZOATE 144851-82-1
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02