ChemicalBook > CAS DataBase List > (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
- Product Name
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
- CAS No.
- 334769-80-1
- Chemical Name
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
- Synonyms
- (2S,5S)-1-(tert-Butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid;EOS-60522;GS-5817 interMediate;Boc-cis-5-methyl-Pro-OH;(2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid;(2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic aci;(2s,5s)-n-boc-5-methylpyrrolidine-2-carboxylic acid;(2S,5S)-1-Boc-5-methylpyrrolidine-2-carboxylic Acid;cis-5-Methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
- CBNumber
- CB21267594
- Molecular Formula
- C11H19NO4
- Formula Weight
- 229.27
- MOL File
- 334769-80-1.mol
More
Less
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Property
- Boiling point:
- 343.2±35.0 °C(Predicted)
- Density
- 1.150
- storage temp.
- 2-8°C
- pka
- 4.02±0.40(Predicted)
- Appearance
- White to off-white Solid
More
Less
N-Bromosuccinimide Price
ChemScene
- Product number
- CS-D0422
- Product name
- (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylicacid
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB152064
- Product name
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylicacid
- Packaging
- 500mg
- Price
- $170
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB152064
- Product name
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylicacid
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-D0422
- Product name
- (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylicacid
- Purity
- ≥97.0%
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB152064
- Product name
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylicacid
- Packaging
- 2g
- Price
- $360
- Updated
- 2021/12/16
More
Less
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
676560-83-1
334769-80-1
The general procedure for the synthesis of (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid from the compound (CAS: 676560-83-1) is as follows: 1. ethyl (2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylate (6.46 g, 25.1 mmol) was dissolved in ethanol (20 mL). 2. Lithium hydroxide monohydrate (2.11 g, 50.2 mmol) and deionized water (12 mL) were added to the above solution. 3. The reaction mixture was stirred at room temperature for 16 hours. 4. 4. Upon completion of the reaction, the mixture was partitioned between ethyl acetate and a 1:1 mixture of saturated aqueous sodium chloride solution and 1N hydrochloric acid. 5. The aqueous layer was separated and extracted again with ethyl acetate. 6. Combine all organic layers and dry with anhydrous sodium sulfate. 7. Vacuum removal of the solvent afforded (2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid as a white solid (quantitative yield), which was used directly in the next reaction without further purification.
References
[1] Patent: US2014/178336, 2014, A1. Location in patent: Paragraph 0252
[2] Patent: US2015/361087, 2015, A1. Location in patent: Paragraph 0311; 0316
[3] Patent: WO2015/110048, 2015, A1. Location in patent: Paragraph 00165
[4] Patent: US2017/44140, 2017, A1. Location in patent: Paragraph 0218; 0231; 0232; 0233
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3520 - 3535
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 021-58955608,2250286 15921236618
- blinkzeng@gmail.com
- Country
- China
- ProdList
- 522
- Advantage
- 62
- Tel
- 13477084141; 13477084141
- Fax
- +86(27)65566697
- sales@luohuapharm.com
- Country
- China
- ProdList
- 468
- Advantage
- 60
- Tel
- 021-53292253
- Fax
- 021-53292253
- biz@synches.com
- Country
- China
- ProdList
- 199
- Advantage
- 64
- Tel
- 021-50793966 18917198199
- Fax
- +86-21-50793967
- info@synfarm.com
- Country
- China
- ProdList
- 280
- Advantage
- 58
- Tel
- 021-02136680027 15800370750
- 1706640024@qq.com
- Country
- China
- ProdList
- 570
- Advantage
- 56
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 18860950986
- tangmanman@zenjipharma.com
- Country
- China
- ProdList
- 1733
- Advantage
- 55
- Tel
- 021-38681880 13817889927
- Fax
- 0213390-8196
- sales@synmedia-chem.com
- Country
- China
- ProdList
- 249
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 028-87078428 028-87074958
- Fax
- 8772-8116
- chengzhenyong@cdfirster.com
- Country
- China
- ProdList
- 2598
- Advantage
- 60
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 0519-83984084
- Fax
- 0519-88776993
- sales@ydpharm.com
- Country
- China
- ProdList
- 119
- Advantage
- 60
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 020-38082199,29065168,38082986,29878298,29866629,4000192398
- Fax
- +86 (20)38082986
- Country
- China
- ProdList
- 830
- Advantage
- 60
- Tel
- +86-18512541987
- Fax
- 0555-5963572
- hll@farmasino.com
- Country
- China
- ProdList
- 241
- Advantage
- 60
- Tel
- 0571-89081561; 10006559855
- Fax
- 0571 89081561
- info@cheminspire.com
- Country
- China
- ProdList
- 412
- Advantage
- 58
- Tel
- 17317567081
- info@coreuni.com
- Country
- China
- ProdList
- 201
- Advantage
- 55
- Tel
- 18055517827
- sales@agilebiochem.com
- Country
- China
- ProdList
- 1003
- Advantage
- 50
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- Fax
- -
- 13006575422@163.com
- Country
- China
- ProdList
- 6355
- Advantage
- 58
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 12475
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-58950110 13124863828
- Fax
- 021-20922272
- sales@linkchem.cn
- Country
- China
- ProdList
- 2998
- Advantage
- 58
- Tel
- 028-64950838 17340131597
- bd-focus@focuspharm.com
- Country
- China
- ProdList
- 850
- Advantage
- 58
- Tel
- 021-69156110 13611751650
- Fax
- 021-69156110
- leefloor2016@163.com
- Country
- CHINA
- ProdList
- 296
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- sales@twochem.com
- Country
- China
- ProdList
- 1788
- Advantage
- 58
- Tel
- +86 18516118859
- Fax
- +86 (21) 2096 2272
- sales@chainpeptide.com
- Country
- CHINA
- ProdList
- 419
- Advantage
- 58
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 18962082606
- Fax
- QQ: 3394205705
- 3394205705@qq.com
- Country
- China
- ProdList
- 1751
- Advantage
- 58
- Tel
- 400-668-9898
- Fax
- 010-51582189
- service@3achem.com
- Country
- China
- ProdList
- 20557
- Advantage
- 58
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4877
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 028-84641798 18782128315
- 3302391190@qq.com
- Country
- China
- ProdList
- 9799
- Advantage
- 55
- Tel
- zhiqianbio@126.com
- Country
- China
- ProdList
- 19778
- Advantage
- 58
- Tel
- 021-50676523 18019098996
- info@acelybio.com
- Country
- China
- ProdList
- 3960
- Advantage
- 58
- Tel
- 18028661570
- 2412659056@qq.com
- Country
- China
- ProdList
- 291
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- 571-86758373 +8613588754946
- Fax
- 0086-571-81131109
- sales@huarongpharm.com
- Country
- CHINA
- ProdList
- 3148
- Advantage
- 58
- Tel
- +86-0571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- China
- ProdList
- 52846
- Advantage
- 58
- Tel
- +8615056975894
- Fax
- 86-0551-62678551
- shawn@hirisunpharm.com
- Country
- CHINA
- ProdList
- 9911
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15109
- Advantage
- 58
More
Less
View Lastest Price from (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid manufacturers
Career Henan Chemical Co
- Product
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid 334769-80-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-27
334769-80-1, (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acidRelated Search:
tert-Butanol
Folic acid
N-Vinyl-2-pyrrolidone
Kresoxim-methyl
Povidone iodine
Polyvinylpyrrolidone
Methylparaben
N-Methyl-2-pyrrolidone
Bensulfuron methyl
Citric acid
Thiophanate-methyl
Ascoric Acid
Methyl
METHYL-2-PYRROLIDONE
Carbonyl iron powder
Methyl bromide
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
CARBOXYLIC ACID