ChemicalBook > CAS DataBase List > (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
- Product Name
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
- CAS No.
- 334769-80-1
- Chemical Name
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid
- Synonyms
- (2S,5S)-1-(tert-Butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid;EOS-60522;GS-5817 interMediate;Boc-cis-5-methyl-Pro-OH;(2S,5S)-Boc-5-methylpyrrolidine-2-carboxylic acid;(2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic aci;(2s,5s)-n-boc-5-methylpyrrolidine-2-carboxylic acid;(2S,5S)-1-Boc-5-methylpyrrolidine-2-carboxylic Acid;cis-5-Methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;(2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
- CBNumber
- CB21267594
- Molecular Formula
- C11H19NO4
- Formula Weight
- 229.27
- MOL File
- 334769-80-1.mol
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(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Property
- Boiling point:
- 343.2±35.0 °C(Predicted)
- Density
- 1.150
- storage temp.
- 2-8°C
- pka
- 4.02±0.40(Predicted)
- Appearance
- White to off-white Solid
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-D0422
- Product name
- (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylicacid
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-D0422
- Product name
- (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylicacid
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB152064
- Product name
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylicacid
- Packaging
- 500mg
- Price
- $170
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB152064
- Product name
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylicacid
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-D0422
- Product name
- (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylicacid
- Purity
- ≥97.0%
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
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(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
676560-83-1
334769-80-1
The general procedure for the synthesis of (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid from the compound (CAS: 676560-83-1) is as follows: 1. ethyl (2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylate (6.46 g, 25.1 mmol) was dissolved in ethanol (20 mL). 2. Lithium hydroxide monohydrate (2.11 g, 50.2 mmol) and deionized water (12 mL) were added to the above solution. 3. The reaction mixture was stirred at room temperature for 16 hours. 4. 4. Upon completion of the reaction, the mixture was partitioned between ethyl acetate and a 1:1 mixture of saturated aqueous sodium chloride solution and 1N hydrochloric acid. 5. The aqueous layer was separated and extracted again with ethyl acetate. 6. Combine all organic layers and dry with anhydrous sodium sulfate. 7. Vacuum removal of the solvent afforded (2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid as a white solid (quantitative yield), which was used directly in the next reaction without further purification.
References
[1] Patent: US2014/178336, 2014, A1. Location in patent: Paragraph 0252
[2] Patent: US2015/361087, 2015, A1. Location in patent: Paragraph 0311; 0316
[3] Patent: WO2015/110048, 2015, A1. Location in patent: Paragraph 00165
[4] Patent: US2017/44140, 2017, A1. Location in patent: Paragraph 0218; 0231; 0232; 0233
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3520 - 3535
(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials
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View Lastest Price from (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid manufacturers
Career Henan Chemical Co
- Product
- (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid 334769-80-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-27
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