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Estramustine sodium phosphate

Product Name
Estramustine sodium phosphate
CAS No.
52205-73-9
Chemical Name
Estramustine sodium phosphate
Synonyms
emcyt;C13031;Estracyt;NSC 89199;iumphosphate;Ro 21-8837/001;estracytsodium;4-(550-Butyl)phenol;Estramustin sodium phosphate;ESTRAMUSTINE PHOSPHATE SODIUM
CBNumber
CB2127417
Molecular Formula
C23H33Cl2NNaO6P
Formula Weight
544.38
MOL File
52205-73-9.mol
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Estramustine sodium phosphate Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: soluble50mg/mL
form 
A crystalline solid
color 
White to off-white
Stability:
Hygroscopic, Unstable in Solution
CAS DataBase Reference
52205-73-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37
Safety Statements 
26
WGK Germany 
3
RTECS 
KG7350000
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E0407
Product name
Estramustine sodium phosphate
Packaging
25mg
Price
$193
Updated
2024/03/01
Sigma-Aldrich
Product number
E0407
Product name
Estramustine sodium phosphate
Packaging
5mg
Price
$46.4
Updated
2023/06/20
Cayman Chemical
Product number
23126
Product name
Estramustine Phosphate (sodium salt)
Purity
≥95%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23126
Product name
Estramustine Phosphate (sodium salt)
Purity
≥95%
Packaging
50mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
23126
Product name
Estramustine Phosphate (sodium salt)
Purity
≥95%
Packaging
100mg
Price
$201
Updated
2024/03/01
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Estramustine sodium phosphate Chemical Properties,Usage,Production

Description

Estramustine phosphate is a derivative of estradiol (Item Nos. 20776 | 10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 μM for MAP-1 and MAP-2, respectively. Estramustine induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells and induces apoptosis in U87MG human malignant glioma cells. The metabolites of estramustine phosphate have anti-androgenic effects. Formulations containing estramustine phosphate are used in the palliative treatment of prostate cancer.

Uses

Estramustine phosphate sodium USP (Emcyt) is used to treat Prostatic carcinoma.

Uses

Estramustine sodium phosphate is binds estradiol receptors irreversibly.

Uses

Antineoplastic.

Definition

ChEBI: An organic sodium salt which is the disodium salt of estramustine phosphate.

brand name

Emcyt (Pharmacia & Upjohn).

General Description

Estramustine as the phosphate is available in 140-mg capsulesfor the treatment of prostate cancer. Although originallydesigned as an alkylating agent, it has been shown tobe devoid of alkylating activity and functions as an inhibitorof microtubule function by binding to microtubule associate proteins (MAPs) and also binds to tubulin at a site that isdistinct from that of the vinca alkaloids but thought to partiallyoverlap with that of pacilataxel.The major mechanismby which cells become resistant to the agent involvesincreased efflux, although this is not mediated by Pgp as isthe case with other microtubule inhibitors such as the taxanesand vinca alkaloids. Therefore, the agent does not showcross-resistance with these agents. As an inhibitor of microtubules,it is cell cycle specific acting in the M phase. Theagent is well absorbed upon oral administration with hydrolysisof the water solubilizing phosphate beginning to occurin the GI tract. Metabolism involves the formation of theactive estromustine, which arises from oxidation of the C17alcohol to give the ketone. Additional inactive metabolitesresult from carbamate hydrolysis to give estradiol and estrone.The parent and metabolites are primarily eliminatedin the feces with a terminal elimination half-life of 20 hours.The adverse effects of the agent are nausea and vomiting,which is generally mild but the severity may increase uponprolonged administration. Gynecomastia also commonlyoccurs, and diarrhea may also be seen. Less commonly seeneffects include myelosuppression, skin rash, and cardiovascularabnormalities including CHF.

Estramustine sodium phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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Estramustine sodium phosphate Suppliers

China 78 Germany 1 India 5 United Kingdom 5 United States 17 Global 106
LGM Pharma
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1-(800)-881-8210
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inquiries@lgmpharma.com
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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sales@aladdinsci.com
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TargetMol Chemicals Inc.
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Cayman Chemical Company
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United States Biological
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MedChemExpress
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View Lastest Price from Estramustine sodium phosphate manufacturers

Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
Estramustine sodium phosphate 52205-73-9
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98
Supply Ability
1000
Release date
2025-01-09
Dideu Industries Group Limited
Product
Estramustine sodium phosphate 52205-73-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-05
Career Henan Chemical Co
Product
Estramustine sodium phosphate 52205-73-9
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-07

52205-73-9, Estramustine sodium phosphateRelated Search:

Digold trioxide Dexamethasone 21-phosphate disodium salt sodium hexametaphosphate Pentasodium triphosphate hexhydrate Estramustine Phosphoric acid, isooctyl ester 4-cyclohexyl-phenol carbamate MPMC PHOSPHORIC ACID MONO-N-DODECYL ESTER SODIUM SALT 2-Chloroethyl carbamate (2-ETHYLHEXYL) PHOSPHATE DIETHYL-CARBAMIC ACID PHENYL ESTER estra-1,3,5(10)-triene-3,17beta-diol 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) Estramustine sodium phosphate

  • ESTRAMUSTINE PHOSPHATE SODIUM
  • -(dihydrogenphosphate),disodiumsalt
  • iumphosphate
  • Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt
  • Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt
  • Estracyt
  • Estramustine phosphate disodium salt
  • NSC 89199
  • Ro 21-8837/001
  • Estra-1,3,5(10)-trien-3,17-diol-(17beta)-, 3-(Bis(2-chlorethyl)carbamat) 17-(Dihydrogen-phosphat), Dinatriumsalz
  • (17-beta)-Estra-1,3,5(10)-triene-3,17-diol 3-(bis(2-chloroethyl)carbamate) 17-(dihydrogenphosphate) disodium salt
  • Estramustine sodium phosphate, 97%, antimicrotubule chemotherapy agent
  • Estramustine Phosphate (sodium salt)
  • ESTRAMUSTINE SODIUM PHOSPHATE
  • disodium [3-[bis(2-chloroethyl)amino-oxomethoxy]-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] phosphate
  • 3,5(10)-triene-3,17-diol(17-beta)-estra-3-(bis(2-chloroethyl)carbamate)17
  • 1,3,5(10)-Estratriene-3,17β-diol 3-[bis(2-chloroethyl)carbamate]17-[phosphoric acid disodium] salt
  • C13031
  • Estramustine Sodium Phosphate & Estramustine Base
  • Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbaMate] 17-(dihydrogen phosphate), sodiuM salt(1:2)
  • Estra-1,3,5(10)triene-3,17-diol 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate) sodium salt
  • Estradiol 3-bis(2-chloroethyl)carbamate 17-(dihydrogen phosphate) sodium salt
  • emcyt
  • estra-1,3,5(10)-triene-3,17-beta-diol3-(bis(2-chloroethyl)carbamate)17-disod
  • estracytsodium
  • estramustinephosphatedisodium
  • Estramustine sodium phosphate USP/EP/BP
  • Estramustin sodium phosphate
  • Estramustine sodium phosphateQ: What is Estramustine sodium phosphate Q: What is the CAS Number of Estramustine sodium phosphate Q: What is the storage condition of Estramustine sodium phosphate
  • 4-(550-Butyl)phenol
  • Sodium (8R,9S,13S,14S,17S)-3-((bis(2-chloroethyl)carbamoyl)oxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl phosphate
  • 52205-73-9
  • 55205-73-9
  • C23H30Cl2NNa2O6P
  • C23H32NO6PNa
  • C23H30Cl2NO6P2Na
  • Active Pharmaceutical Ingredients
  • Intermediates
  • Other APIs