5-Aminoisoindolin-1-one
- Product Name
- 5-Aminoisoindolin-1-one
- CAS No.
- 222036-66-0
- Chemical Name
- 5-Aminoisoindolin-1-one
- Synonyms
- 5-aminoisoindolin-1-one;5-aMinoisoindoline-1-one;5-aMino-2,3-dihydro- Isoindol-1-one;5-amino-2,3-dihydro-1H-Isoindol-1-one;1H-Isoindol-1-one, 5-amino-2,3-dihydro;5-Aminoisoindolin-1-one ISO 9001：2015 REACH;1H-Isoindol-1-one,5-amino-2,3-dihydro-(9CI)
- CBNumber
- CB21276060
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 222036-66-0.mol
5-Aminoisoindolin-1-one Property
- Melting point:
- 197-199 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 520.0±50.0 °C(Predicted)
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 15.12±0.20(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C8H8N2O/c9-6-1-2-7-5(3-6)4-10-8(7)11/h1-3H,4,9H2,(H,10,11)
- InChIKey
- RGJCJWXNNDARPQ-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(N)C=C2)CN1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A611590
- Product name
- 5-Aminoisoindolin-1-one
- Packaging
- 100mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 077850
- Product name
- 5-Amino-2,3-dihydro-1H-isoindol-1-one
- Purity
- 98%
- Packaging
- 250mg
- Price
- $35
- Updated
- 2021/12/16
- Product number
- W4579
- Product name
- 5-Aminoisoindolin-1-one
- Packaging
- 5g
- Price
- $331
- Updated
- 2021/12/16
- Product number
- 4H48-1-21
- Product name
- 5-Amino-2,3-dihydro- isoindol-1-one
- Purity
- 98%
- Packaging
- 1g
- Price
- $445
- Updated
- 2021/12/16
- Product number
- CHM0117386
- Product name
- 5-AMINOISOINDOLIN-1-ONE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $750.75
- Updated
- 2021/12/16
5-Aminoisoindolin-1-one Chemical Properties,Usage,Production
Uses
5-Aminoisoindolin-1-one is used in the synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on the isoindolone skeleton.
Synthesis
110568-64-4
222036-66-0
General procedure for the synthesis of 5-amino-2,3-dihydroisoindol-1-one from 6-nitro-isoindolin-1-one: A mixture of 6-nitro-isoindolin-1-one (100 mg, 0.56 mmol), and reduced iron powder (314 mg, 5.6 mmol) was added to ethanol (2.0 mL) and concentrated hydrochloric acid (0.5 mL) and heated and refluxed for 2 hours. The completion of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, it was cooled to room temperature, the acid in the reaction solution was neutralized with a methanol solution saturated with ammonia (NH3), filtered through diatomaceous earth, the filtrates were washed with methanol, the filtrates were combined and the solvent was evaporated under reduced pressure to give 5-amino-2,3-dihydroisoindol-1-one (70.0 mg, 84% yield) as a white solid.
References
[1] Patent: CN103804358, 2016, B. Location in patent: Paragraph 0126
[2] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 57
[3] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 287
[4] Patent: WO2006/17443, 2006, A2. Location in patent: Page/Page column 154-155
[5] Patent: US2010/15141, 2010, A1. Location in patent: Page/Page column 26
5-Aminoisoindolin-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Aminoisoindolin-1-one manufacturers
- Product
- 1H-Isoindol-1-one, 5-amino-2,3-dihydro 222036-66-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 1H-Isoindol-1-one, 5-amino-2,3-dihydro 222036-66-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
- Product
- 5-Aminoisoindolin-1-one 222036-66-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25