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Dantrolene sodium salt

Product Name
Dantrolene sodium salt
CAS No.
14663-23-1
Chemical Name
Dantrolene sodium salt
Synonyms
F-440;DANTRIUM;DANTROLENE NA;DantroloneSodium;SODIUM DANTROLENE;dantorolenesodium;Aantrolene Sodium;Dantrolene, sodium s;DANTROLENE SODIUM SALT;dantrolene sodium price
CBNumber
CB2128232
Molecular Formula
C14H11N4NaO5
Formula Weight
338.25
MOL File
14663-23-1.mol
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Dantrolene sodium salt Property

storage temp. 
Store at RT
solubility 
Soluble in DMSO (up to 3 mg/ml)
form 
Orange solid
color 
Orange
Merck 
14,2816
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
InChIKey
KSRLIXGNPXAZHD-HAZZGOGXSA-M
CAS DataBase Reference
14663-23-1(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
MU3875000
HS Code 
2942.00.3500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D9175
Product name
Dantrolene sodium salt
Packaging
1g
Price
$607
Updated
2024/03/01
Sigma-Aldrich
Product number
251680
Product name
Dantrolene, Sodium Salt
Packaging
100mg
Price
$96.7
Updated
2024/03/01
TCI Chemical
Product number
D3996
Product name
Dantrolene Sodium Salt Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$124
Updated
2024/03/01
TCI Chemical
Product number
D3996
Product name
Dantrolene Sodium Salt Hydrate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$382
Updated
2024/03/01
Alfa Aesar
Product number
J60887
Product name
Dantrolene sodium salt
Packaging
100mg
Price
$68.65
Updated
2024/03/01
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Dantrolene sodium salt Chemical Properties,Usage,Production

Description

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 μg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.

Chemical Properties

mp 279-280C 3415821

Uses

Skeletal muscle relaxant;Blocker of Ca2+ release

Uses

Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.

Definition

ChEBI: The anhydrous sodium salt of dantrolene.

brand name

Dantrium (Procter & Gamble).

Biological Activity

Inhibits release of Ca 2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

storage

Store at RT

References

1) Zhao?et al.?(2001),?Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem.,?276?13810 2) Frandsen and Schousboe (1992),?Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA,?89?2590 3) Muehlschlegel and Sims (2009),?Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care,?10?103 4) Lu?et al.?(2014),?A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA,?111?E5292

Dantrolene sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Dantrolene sodium salt Suppliers

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View Lastest Price from Dantrolene sodium salt manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dantrolene sodium salt 14663-23-1
Price
US $0.00-0.00/g
Min. Order
50g
Purity
90~96%,USP40
Supply Ability
50kg/month
Release date
2021-05-28
Baoji Guokang Bio-Technology Co., Ltd.
Product
Dantrolene sodium salt 14663-23-1
Price
US $683.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2021-06-04
Baoji Guokang Healthchem co.,ltd
Product
Dantrolene sodium salt 14663-23-1
Price
US $634.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
800kg
Release date
2021-06-03

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