6-METHOXYPYRIDINE-2-CARBOXYLIC ACID
- Product Name
- 6-METHOXYPYRIDINE-2-CARBOXYLIC ACID
- CAS No.
- 26893-73-2
- Chemical Name
- 6-METHOXYPYRIDINE-2-CARBOXYLIC ACID
- Synonyms
- 1-Naphthalene bromide;6-METHOXYPICOLINIC ACID;Picolinic acid, 6-methoxy-;2-methoxy-6-picolinic acid;6-Methoxypyridine-2-carboxyL;6-methoxypyridine-2-carboxylicaci;6-Methoxypyridin-2-carboxylic acid;6-METHOXYPYRIDINE-2-CARBOXYLIC ACID;6-METHOXY-2-PYRIDINECARBOXYLIC ACID;2-methoxypyridine-6-carboxylic acid
- CBNumber
- CB2128292
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 26893-73-2.mol
6-METHOXYPYRIDINE-2-CARBOXYLIC ACID Property
- Melting point:
- 38.5-39.5°C
- Boiling point:
- 300.8±22.0 °C(Predicted)
- Density
- 1.284±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 3.52±0.10(Predicted)
- color
- White to Almost white
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C7H7NO3/c1-11-6-4-2-3-5(8-6)7(9)10/h2-4H,1H3,(H,9,10)
- InChIKey
- QCCJUEURAZMEGY-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC(OC)=CC=C1
- CAS DataBase Reference
- 26893-73-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 679607
- Product name
- 6-Methoxypyridine-2-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $70.9
- Updated
- 2023/06/20
- Product number
- M2189
- Product name
- 6-Methoxypyridine-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- M2189
- Product name
- 6-Methoxypyridine-2-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $191
- Updated
- 2025/07/31
- Product number
- M266460
- Product name
- 6-Methoxypicolinicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4H21-1-2Y
- Product name
- 6-Methoxypyridine-2-carboxylic acid
- Packaging
- 10g
- Price
- $128
- Updated
- 2021/12/16
6-METHOXYPYRIDINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Synthesis
19621-92-2
74-88-4
26893-73-2
General procedure for the synthesis of 6-methoxypyridine-2-carboxylic acid from 6-hydroxypyridine-2-carboxylic acid and iodomethane: To a solution of 6-hydroxypyridine-2-carboxylic acid (1.39 g, 10.0 mmol) in toluene (35 mL) was added silver oxide (2.43 g, 10.5 mmol) and the mixture was stirred for 30 minutes. Subsequently, iodomethane (1.31 mL, 21.0 mmol) was added to the reaction system and the reaction mixture was heated to reflux and reacted overnight. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated to give 1.45 g of methyl 6-methoxypyridine-2-carboxylate as a yellow solid. The solid was dissolved in tetrahydrofuran (50 mL) and then added to a mixture of 5N NaOH (20 mL, 100 mmol) and water (5 mL). After 1 hour of reaction, the reaction mixture was acidified to pH 3 with 5N HCl and then concentrated. To the resulting white solid, 20% MeOH/CHCl3 solvent mixture was added and the mixture was sonicated for 20 min. The mixture was filtered and the mother liquor was dried with anhydrous MgSO4 and concentrated to give 1.33 g of 6-methoxypyridine-2-carboxylic acid as a white solid in 87% yield. The product was confirmed to be structurally consistent by 1H NMR and MS (ion spray) showed m/z 152 (M-).
References
[1] Patent: US2003/100576, 2003, A1
6-METHOXYPYRIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-METHOXYPYRIDINE-2-CARBOXYLIC ACID manufacturers
- Product
- 6-METHOXYPYRIDINE-2-CARBOXYLIC ACID 26893-73-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-03
- Product
- 6-METHOXYPYRIDINE-2-CARBOXYLIC ACID 26893-73-2
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 6-METHOXYPYRIDINE-2-CARBOXYLIC ACID 26893-73-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25