6-Chloro-4-methoxynicotinic acid

Product Name: 6-Chloro-4-methoxynicotinic acid
CAS No.: 716362-10-6
Chemical Name: 6-Chloro-4-methoxynicotinic acid
Synonyms: 6-Chloro-4-methoxynicotinicAci;6-Chloro-4-methoxynicotinic acid;6-Chloro-4-methoxy-pyridin-3-carboxylic acid;6-Chloro-4-methoxy-3-pyridinecarboxylic acid;6-chloro-4-Methoxypyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-chloro-4-Methoxy-
CBNumber: CB41503993
Molecular Formula: C7H6ClNO3
Formula Weight: 187.58
MOL File: 716362-10-6.mol

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6-Chloro-4-methoxynicotinic acid Property

Boiling point:: 350.7±37.0 °C(Predicted)
Density: 1.430
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.13±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C7H6ClNO3/c1-12-5-2-6(8)9-3-4(5)7(10)11/h2-3H,1H3,(H,10,11)
InChIKey: DFXUFJAAXAJWSA-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=CC(OC)=C1C(O)=O

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Safety

Safety Statements: 24/25
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C368730
Product name: 6-Chloro-4-methoxyNicotinicAcid
Packaging: 1g
Price: $155
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20095
Product name: 6-Chloro-4-methoxy nicotinic acid
Packaging: 2g
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20095
Product name: 6-Chloro-4-methoxy nicotinic acid
Packaging: 5G
Price: $375
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0028189
Product name: 3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-4-METHOXY-
Purity: 95.00%
Packaging: 1G
Price: $771.89
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20095
Product name: 6-Chloro-4-methoxy nicotinic acid
Packaging: 10g
Price: $790
Updated: 2021/12/16

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6-Chloro-4-methoxynicotinic acid Chemical Properties,Usage,Production

Uses

6-Chloro-4-methoxynicotinic acid is used for preparation of benzimidazolylazabicyclooctylethylpiperidines as Ccr5 antagonists for the treatment of HIV infection.

Synthesis

84332-02-5

716362-10-6

General procedure for the synthesis of 6-chloro-4-methoxynicotinic acid from methyl 6-chloro-4-methoxynicotinate: lithium hydroxide (1.84 g, 43.9 mmol) was added to a solution of the intermediate from step 2 (2.94 g, 14.6 mmol) in a mixture of methanol (30 mL), tetrahydrofuran (30 mL) and water (3 mL) at 0°C. The reaction mixture was stirred at room temperature for 3 hours. The volatiles were removed under reduced pressure and the residue was diluted with water and washed with dichloromethane. The aqueous layer was acidified to pH ≈ 3 with sodium bisulfate solution and extracted with dichloromethane. The combined organic layers were dried and the volatiles were removed under reduced pressure to give the target product 6-chloro-4-methoxynicotinic acid (2.7 g, 98% yield).

References

[1] Patent: US2015/166505, 2015, A1. Location in patent: Paragraph 0342; 0349; 0350
[2] Patent: WO2012/110860, 2012, A1. Location in patent: Page/Page column 99

6-Chloro-4-methoxynicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-4-methoxynicotinic acid Suppliers

Canada 1 China 109 Germany 1 India 3 United Kingdom 2 United States 11 Global 127

Wuxi InterpiPharm, Inc.

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J & K SCIENTIFIC LTD.

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Accela ChemBio Co.,Ltd.

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Nanjing Chemlin Chemical Co., Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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View Lastest Price from 6-Chloro-4-methoxynicotinic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 6-Chloro-4-methoxynicotinic acid 716362-10-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

LY Global chemicals co.,ltd .

Product: 6-Chloro-4-methoxynicotinic acid 716362-10-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98% Min
Supply Ability: 1000kg
Release date: 2023-03-18

Career Henan Chemical Co

Product: 6-Chloro-4-methoxynicotinic acid 716362-10-6
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g； 1kg; 25kg
Release date: 2020-01-10

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6-Chloro-4-methoxynicotinicAci

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716362-10-6

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