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6-Chloro-4-methoxynicotinic acid

Product Name
6-Chloro-4-methoxynicotinic acid
CAS No.
716362-10-6
Chemical Name
6-Chloro-4-methoxynicotinic acid
Synonyms
6-Chloro-4-methoxynicotinicAci;6-Chloro-4-methoxynicotinic acid;6-Chloro-4-methoxy-pyridin-3-carboxylic acid;6-Chloro-4-methoxy-3-pyridinecarboxylic acid;6-chloro-4-Methoxypyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-chloro-4-Methoxy-
CBNumber
CB41503993
Molecular Formula
C7H6ClNO3
Formula Weight
187.58
MOL File
716362-10-6.mol
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6-Chloro-4-methoxynicotinic acid Property

Boiling point:
350.7±37.0 °C(Predicted)
Density 
1.430
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
3.13±0.10(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C7H6ClNO3/c1-12-5-2-6(8)9-3-4(5)7(10)11/h2-3H,1H3,(H,10,11)
InChIKey
DFXUFJAAXAJWSA-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=CC(OC)=C1C(O)=O
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Safety

Safety Statements 
24/25
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368730
Product name
6-Chloro-4-methoxyNicotinicAcid
Packaging
1g
Price
$155
Updated
2021/12/16
Matrix Scientific
Product number
048589
Product name
6-Chloro-4-methoxynicotinic acid
Purity
95+%
Packaging
1g
Price
$54
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20095
Product name
6-Chloro-4-methoxy nicotinic acid
Packaging
500mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20095
Product name
6-Chloro-4-methoxy nicotinic acid
Packaging
1g
Price
$100
Updated
2021/12/16
Matrix Scientific
Product number
048589
Product name
6-Chloro-4-methoxynicotinic acid
Purity
95+%
Packaging
5g
Price
$147
Updated
2021/12/16
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6-Chloro-4-methoxynicotinic acid Chemical Properties,Usage,Production

Uses

6-Chloro-4-methoxynicotinic acid is used for preparation of benzimidazolylazabicyclooctylethylpiperidines as Ccr5 antagonists for the treatment of HIV infection.

Synthesis

84332-02-5

716362-10-6

General procedure for the synthesis of 6-chloro-4-methoxynicotinic acid from methyl 6-chloro-4-methoxynicotinate: lithium hydroxide (1.84 g, 43.9 mmol) was added to a solution of the intermediate from step 2 (2.94 g, 14.6 mmol) in a mixture of methanol (30 mL), tetrahydrofuran (30 mL) and water (3 mL) at 0°C. The reaction mixture was stirred at room temperature for 3 hours. The volatiles were removed under reduced pressure and the residue was diluted with water and washed with dichloromethane. The aqueous layer was acidified to pH ≈ 3 with sodium bisulfate solution and extracted with dichloromethane. The combined organic layers were dried and the volatiles were removed under reduced pressure to give the target product 6-chloro-4-methoxynicotinic acid (2.7 g, 98% yield).

References

[1] Patent: US2015/166505, 2015, A1. Location in patent: Paragraph 0342; 0349; 0350
[2] Patent: WO2012/110860, 2012, A1. Location in patent: Page/Page column 99

6-Chloro-4-methoxynicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-4-methoxynicotinic acid Suppliers

Canada 1 China 109 Germany 1 India 3 United Kingdom 2 United States 11 Global 127
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
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View Lastest Price from 6-Chloro-4-methoxynicotinic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
6-Chloro-4-methoxynicotinic acid 716362-10-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
LY Global chemicals co.,ltd .
Product
6-Chloro-4-methoxynicotinic acid 716362-10-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98% Min
Supply Ability
1000kg
Release date
2023-03-18
Career Henan Chemical Co
Product
6-Chloro-4-methoxynicotinic acid 716362-10-6
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g； 1kg; 25kg
Release date
2020-01-10

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