GS 389

Product Name: GS 389
CAS No.: 41498-37-7
Chemical Name: GS 389
Synonyms: GS 389;HIGE-004;1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(4-methoxybenzyl)isoquinoline;1,2,3,4-Tetrahydro-1-(4-methoxybenzyl)-6,7-dimethoxyisoquinoline;6,7-Dimethoxy-1-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline;Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-;6,7-diMethoxy-1-(4-Methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-2-iuM chloride
CBNumber: CB21303890
Molecular Formula: C19H23NO3
Formula Weight: 313.39
MOL File: 41498-37-7.mol

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GS 389 Property

Melting point:: 200-203 °C
Boiling point:: 454.0±45.0 °C(Predicted)
Density: 1.108±0.06 g/cm3(Predicted)
pka: 8.75±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0001894
Product name: GS-389
Purity: 95.00%
Packaging: 5MG
Price: $500.24
Updated: 2021/12/16

Chemenu

Product number: CM143107
Product name: 6,7-dimethoxy-1-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
Purity: 95%
Packaging: 1g
Price: $830
Updated: 2021/12/16

Crysdot

Product number: CD11126634
Product name: 6,7-Dimethoxy-1-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
Purity: 95+%
Packaging: 1g
Price: $880
Updated: 2021/12/16

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GS 389 Chemical Properties,Usage,Production

Description

GS 389 is a novel tetrahydroisoquinoline analog. GS-389 significantly increased cGMP levels in the rat aorta and inhibited cGMP phosphodiesterase from the rabbit brain. It has vasorelaxant properties.

Uses

GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1].

References

[1] Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72(4):327-334. DOI:10.1139/y94-049

GS 389 Preparation Products And Raw materials

Raw materials

Preparation Products

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GS 389 Suppliers

China 7 South Korea 1 United States 2 Global 10

CHEMICAL LAND21

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41498-37-7, GS 389Related Search:

ISOCORYDINE HYDROCHLORIDE DL-LAUDANOSINE Tetrahydropapaverine hydrochloride CURINE DAURICINE BERBAMINE BOLDINE DIMETHYL ETHER D-TUBOCURARINE CHLORIDE TETRAHYDROPALMATINE HYDROCHLORIDE Corydaline OXYACANTHINE HYDROCHLORIDE Cepharanthine ISOCORYDINE HYDROCHLORIDE DL-6'-BROMOLAUDANOSIN L-TETRANDRINE PAVINE HCL AKOS 236-50 (+)-MENISPERINE IODIDE

GS 389

1,2,3,4-Tetrahydro-1-(4-methoxybenzyl)-6,7-dimethoxyisoquinoline

1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(4-methoxybenzyl)isoquinoline

6,7-diMethoxy-1-(4-Methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-2-iuM chloride

6,7-Dimethoxy-1-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

HIGE-004

Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-

41498-37-7