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BERBAMINE

Product Name
BERBAMINE
CAS No.
478-61-5
Chemical Name
BERBAMINE
Synonyms
BERBAINE;BERBAMINE;Bernadine;BERBAMINE USP/EP/BP;6,6’,7-trimethoxy-2,2’-dimethylberbaman-12-ol;6,6’,7-trimethoxy-2,2’-dimethyl-berbaman-12-o;BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL;BERBAMINE: BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL;(4aS,16aR)-3,4,4a,5,16a,17,18,19-Octahydro-21,22,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloicosino[2,3,4-ij]isoquinoline-12-ol;16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol, 3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, (4aS,16aR)-
CBNumber
CB5413494
Molecular Formula
C37H40N2O6
Formula Weight
608.72
MOL File
478-61-5.mol
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BERBAMINE Property

Melting point:
198.5°C
alpha 
D20 +114.6° (c = 1.0 in chloroform)
Boiling point:
655.15°C (rough estimate)
Density 
1.1648 (rough estimate)
refractive index 
1.5300 (estimate)
pka
pKa (20°): 7.33 in aq methanol
CAS DataBase Reference
478-61-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
299996
Product name
Berbamine
Packaging
20mg
Price
$305
Updated
2021/12/16
AK Scientific
Product number
J98904
Product name
Berbamine
Packaging
2g
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007888
Product name
BERBAMINE
Purity
95.00%
Packaging
5G
Price
$1127.86
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB65811
Product name
Berbamine
Packaging
2 g
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0009732
Product name
Berbamine
Purity
99.79%
Packaging
5mg
Price
$50
Updated
2021/12/16
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BERBAMINE Chemical Properties,Usage,Production

Description

Berbamine is an alkaloid, separated from Berberidaceae, Menispermaceae, or Ranunculaceae plants. Most of Berberidaceae plants have medicinal value, including their root, root bark, and stem. The plants of Berberis L. and Mahonia Nutt. contain many alkaloids, the most important of which are berberine and a small amount of palmatine, jatrorrhizine, berbamine, oxyacanthine, and so on. These compounds have many biological activities and have been used to replace goldthread and golden cypress. Also they are well succedaneums of berberine in Chinese and Western medicine. Traditional Chinese medicine Oregon grape root has different therapeutic effects for dysentery, enteritis, children pneumonia, and chronic bronchitis. The major treatment diseases of Chinese mahonia are bacillary dysentery, acute gastritis, infectious hepatitis, pneumonia, tuberculosis, bronchitis, sore throat, and so on.

Physical properties

Appearance: odorless and bitter white crystalline, powder, belongs to bisbenzylisoquinoline alkaloid. Melting point: 197–210?°C in petroleum ether. Solubility: easily soluble in dilute hydrochloric acid, sulfuric acid, ethanol, chloroform, and acetone; soluble in ether; slightly soluble in boiling water and petroleum ether; but insoluble in cold water, ammonia, sodium carbonate, and calcium hydroxide solution.

History

Berbamine is an alkaloid mainly from Berberis julianae, Berberis wilsonae, Berberis poiretii, and huanglumu, which belong to Berberidaceae berberis and Mahonia. Nowadays, it mainly comes from chemical synthesis. Berbamine hydrochloride is contained in the 13th volume of the book, Hua xue yao ping di biao sheng guo biao. As early as 1940, the United States scholars had obtained berbamine from Mahonia . Chinese scholars began the research of berbamine extraction and pharmacological activities since the 1980s in the last century .
Although the berbamine study in our country later than the west, the traditional Chinese medicine Berberi’s medicinal records can be traced back to the Tang Dynasty. The book Tang Ben Cao recorded that Oregon grape root could be a therapy for aphtha, kill insects, and remove hot gas in the body. In the Ming Dynasty the book Ben Cao Gang Mu recorded that Oregon grape root could treat metrorrhagia. Now, berbamine is widely used for leukopenia.

Uses

antihypertensive, skeletal muscle relaxant

Indications

Berbamine is contained in the 13th volume of the book, National Standards for Chemical Drugs.
The current clinical dosage is berbamine hydrochloride tablets. It is used in the prevention and treatment of patients with cancer, which is due to radiotherapy- and chemotherapy-induced neutropenia or due to benzene poisoning, radioactive substances, and drug-induced neutropenia.

Pharmacology

Berbamine can promote hematopoietic function, stimulate myeloid proliferation.
Also berbamine can enhance the content of hematopoietic stem cell and granulocyte-colony stimulating factor (G-CSF), then increase the proliferation and differentiation of bone marrow hematopoietic stem cells and granule progenitor cell, which increase the number of peripheral blood leukocytes. Preclinical and clinical studies showed that berbamine was good for the treatment of leukopenia induced by chemotherapy. Berbamine can inhibit the proliferation of many kinds of tumor cells, such as the human high metastatic breast cancer cells MDA-MB-231, non-small cell lung cancer cells A549, liver cancer cells SMMC772l and HepG2, multiple myeloma cells KM3 and RPMl8226, chronic myeloid leukemia (CML) cells KU812, and imatinib-resistant K562 cells .

Clinical Use

Berbamine is used for the prevention and treatment of cancer patients with neutropenia due to radiotherapy, chemotherapy , benzene poisoning, radioactive substances, and drug.

Enzyme inhibitor

This antihypertensive alkaloid (FW = 608.72 g/mol; CAS 478-61-5; Symbol: BBM) from Berberis lyceum and Mahonia swaseyi is a dihydropyridineclass calcium ion blocker. Berbamine also inhibits KM3 cell growth by inducing G1 arrest as well as apoptosis, by blocking NF-kB signaling through up-regulation of A20, down-regulation of IKKa, p-IkBa, and then inhibition of p65 nuclear translocation, all with a resultant decrease in the expression of the downstream targets of NF- kB. BBM potently suppresses liver cancer cell proliferation and induces cancer cell death by targeting Ca2+/calmodulin-dependent protein kinase II (CAMKII). BBM likewise inhibits in vivo tumorigenicity of liver cancer cells in NOD/SCID mice. These effects are recapitulated by short hairpin RNA-mediated CAMKII knockdown, whereas CAMKII overexpression promotes cancer cell proliferation and increases the resistance of liver cancer cells to BBM. CAMKII was hyperphosphorylated in liver tumors compared with the paired peri-tumor tissues, supporting a role of CAMKII in promoting human liver cancer progression and the clinical potential of BBM in liver cancer therapies.

Purification Methods

Crystallise berbamine from pet ether or *C6H6 (with 1*C6H6 m 129-134o). [Bick Aust J Chem 9 111, 118 1956, Beilstein 27 II 891, 27 III/IV 8732.]

BERBAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BERBAMINE Suppliers

Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5947
Advantage
61
BioBioPha Co., Ltd.
Tel
0871-65217109-
Fax
0871-65215563
Email
sales@mail.biobiopha.com
Country
China
ProdList
5688
Advantage
65
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 QQ:1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Cheng Du Micxy Chemical Co.,Ltd
Tel
028-85632863-
Fax
028-85632863
Email
sales@micxy.com;
Country
China
ProdList
13065
Advantage
58
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3228
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
4041
Advantage
66
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2773
Advantage
58
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8074
Advantage
58
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View Lastest Price from BERBAMINE manufacturers

Dideu Industries Group Limited
Product
BERBAMINE DIHYDROCHLORIDE USP/EP/BP 478-61-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-04
Career Henan Chemical Co
Product
BERBAMINE 478-61-5
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-24

478-61-5, BERBAMINERelated Search:


  • 6,6’,7-trimethoxy-2,2’-dimethyl-berbaman-12-o
  • 6,6’,7-trimethoxy-2,2’-dimethylberbaman-12-ol
  • BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL
  • BERBAMINE
  • BERBAMINE: BERBAMAN-12-OL,6,6',7-TRIMETHOXY-2,2'-DIMETHYL
  • BERBAINE
  • (4aS,16aR)-3,4,4a,5,16a,17,18,19-Octahydro-21,22,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloicosino[2,3,4-ij]isoquinoline-12-ol
  • 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol, 3,4,4a,5,16a,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-, (4aS,16aR)-
  • BERBAMINE USP/EP/BP
  • Bernadine
  • 478-61-5
  • C37H41ClN2O62
  • C37H40N2O6
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Alkaloids
  • Anilines, Aromatic Amines and Nitro Compounds