Berberine hydrochloride
- Product Name
- Berberine hydrochloride
- CAS No.
- 633-65-8
- Chemical Name
- Berberine hydrochloride
- Synonyms
- BERBERINE HCL;BBR;BERBERIN HCL;5,6-DIHYDRO-9,10-DIMETHOXY-BENZO[G]-1,3-BENZODIOXOLO[5,6-A]QUINOLIZINIUM, CHLORIDE;CI 75160;Kyoberin;NSC 646666;UMBELLATINE;Benzodioxide;Berberine chL
- CBNumber
- CB3758777
- Molecular Formula
- C20H18ClNO4
- Formula Weight
- 371.81
- MOL File
- 633-65-8.mol
Berberine hydrochloride Property
- Melting point:
- 204-206 °C (dec.)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- methanol: soluble
- form
- Yellow powder
- Colour Index
- 75160
- color
- Yellow powder
- Water Solubility
- SOLUBLE IN COLD WATER
- BRN
- 3836585
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
- InChIKey
- VKJGBAJNNALVAV-UHFFFAOYSA-M
- SMILES
- C12C=C3C(C(OC)=C(OC)C=C3)=C[N+]=1CCC1=CC3=C(OCO3)C=C21.[Cl-]
- CAS DataBase Reference
- 633-65-8
- EPA Substance Registry System
- Berberine chloride (633-65-8)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 24/25-36-26
- RIDADR
- 1544
- WGK Germany
- 2
- RTECS
- DR9866400
- F
- 3-10
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29349990
- Toxicity
- LD50 orl-rat: >15 g/kg KSRNAM 8,654,74
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP1108
- Product name
- Berberine chloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $278
- Updated
- 2024/03/01
- Product number
- 1065210
- Product name
- Berberine Chloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $644
- Updated
- 2024/03/01
- Product number
- 200275
- Product name
- Berberine Chloride
- Purity
- A highly potent and selective oxysterol EBI2 (GPR183) agonist (K
- Packaging
- 25mg
- Price
- $40.3
- Updated
- 2023/01/07
- Product number
- J62311
- Product name
- Berberine chloride
- Packaging
- 5g
- Price
- $47
- Updated
- 2024/03/01
- Product number
- 10006427
- Product name
- Berberine (chloride)
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $20
- Updated
- 2024/03/01
Berberine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
yellow crystalline powder
Uses
An isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. Al so inhibits Activator Protein 1 (AP-1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Treatment with berberine potentially results in the reduced accumulation o f chemotherapeutic drugs.
Uses
An ingredient in some commercial eyewash products.
Uses
Berberine hydrochloride: antiarrhythmic, alpha2 agonist, anticonvulsant, antiinflammatory, antibacterial, antifungal, antitrypanosomal, antineoplastic, immunostimulant
Definition
Berberine Chloride is the orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Berberine is a naturally occurring yellow alkaloid in some plants. Berberine HCL is the native form combine with hydrogen chloride to make it more stable.
Definition
ChEBI: Berberine chloride (TN) is an organic molecular entity.
Biological Functions
Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.
General Description
A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1 nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC50 = 2 nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4+ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.
Biochem/physiol Actions
An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5′-methoxyhydnocarpin (5′-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.
Safety Profile
Poison by intraperitoneal route.Slightly toxic by ingestion. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx andCl-.
Purification Methods
Berberine chloride crystallises from water to give the dihydrate. The anhydrous salt may be obtained by recrystallisation from EtOH/Et2O, wash the crystals with Et2O and dry them in a vacuum. The iodide has m 250o(dec) (from EtOH). [Perkin J Chem Soc 113 503 1918, Kametani et al. J Chem Soc(C) 2036 1969, Beilstein 27 I 515, 27 II 567.]
Clinical claims and research
People most commonly use berberine for diabetes, high levels of cholesterol or other fats in the blood, and high blood pressure. It is also used for burns, canker sores, liver disease, and many other conditions but there is no good scientific evidence to support many of these uses.
Berberine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Berberine hydrochloride manufacturers
- Product
- Berberine hydrochloride 633-65-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥98%HPLC
- Supply Ability
- 20tons
- Release date
- 2024-01-05
- Product
- Berberine hydrochloride 633-65-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 1000 kg
- Release date
- 2024-03-28
- Product
- Berberine hydrochloride 633-65-8
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5ton/month
- Release date
- 2023-12-10