ChemicalBook > CAS DataBase List > 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

Product Name
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
CAS No.
1977-07-7
Chemical Name
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
Synonyms
Dechloroclozapine;Dopamine serotonin antagonist-1;Deschloroclozapine, 10 mM in DMSO;(4-Methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine;11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine;11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;5H-Dibenzo[b,e][1,4]diazepine, 11-(4-methyl-1-piperazinyl)-;inhibit,Inhibitor,Muscarinic acetylcholine receptor,hM4Di,Deschloroclozapine,hM3Dq,muscarinic-based,mAChR,DREADDs;11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepineQ: What is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Q: What is the CAS Number of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
CBNumber
CB21316359
Molecular Formula
C18H20N4
Formula Weight
292.38
MOL File
1977-07-7.mol
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11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Property

Boiling point:
457.5±55.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO : ≥ 83.3 mg/mL (284.90 mM)
pka
7.82±0.20(Predicted)
form 
solid
color 
Yellow
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Safety

WGK Germany 
WGK 3
Storage Class
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications
Acute Tox. 3 Oral
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-M3647
Product name
Deschloroclozapine
Purity
99.79%
Packaging
10mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-M3647
Product name
Deschloroclozapine
Purity
99.79%
Packaging
50mg
Price
$350
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0997406
Product name
11-(4-METHYL-1-PIPERAZINYL)-5H-DIBENZO(B,E)(1,4)DIAZEPINE
Purity
95.00%
Packaging
5MG
Price
$496.91
Updated
2021/12/16
ChemScene
Product number
CS-M3647
Product name
Deschloroclozapine
Purity
99.79%
Packaging
100mg
Price
$550
Updated
2021/12/16
Crysdot
Product number
CD11170784
Product name
11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Purity
97%
Packaging
50mg
Price
$289
Updated
2021/12/16
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11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Chemical Properties,Usage,Production

Biological Activity

Deschloroclozapine is a potent, high-affinity, selective, metabolically stable agonist of muscarinic-based DREADDs.

Synthesis

109-01-3

5814-41-5

1977-07-7

General procedure for the synthesis of 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,E][1,4]diazepin-11-one from N-methylpiperazine and 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one: 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one (105 mg , 0.5 mmol) was placed in a 50 mL round bottom flask. N,N-dimethylaniline (36.3 mg, 0.3 mmol) was added sequentially. An appropriate amount of super-dry trichlorophosphorus and a magnetic stirrer were added and the mixture was stirred under reflux conditions for 12 h at 130°C under nitrogen protection. Upon completion of the reaction, the excess phosphorous trichloride was removed by distillation. Subsequently, the reaction was terminated by adding an appropriate amount of N-methylpiperazine and continued stirring for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). The reaction mixture was extracted with ethyl acetate (3 x 70 mL) and washed sequentially with water. The organic layers were combined and dried by adding anhydrous Na2SO4. After filtration, the residue was concentrated. Purification by column chromatography (eluent: dichloromethane/methanol = 25:1) afforded 110 mg of the target product 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,E][1,4]diazepine in 75% yield.

in vitro

Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM 3 Dq with an EC 50 =0.13 nM. Deschloroclozapine is also a potent agonist for hM 4 Di with an EC 50 =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM 3 Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM.

b>

target

Ki: 6.3 nM (hM 3 Dq), 4.2 nM (hM 4 Di)

storage

Room temperature

References

[1] Patent: CN108586364, 2018, A. Location in patent: Paragraph 0150; 0151; 0152

11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Preparation Products And Raw materials

Raw materials

Preparation Products

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11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Suppliers

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View Lastest Price from 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Dopamine serotonin antagonist-1 1977-07-7
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-23

1977-07-7, 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepineRelated Search:

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  • 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
  • Dopamine serotonin antagonist-1
  • Dechloroclozapine
  • 5H-Dibenzo[b,e][1,4]diazepine, 11-(4-methyl-1-piperazinyl)-
  • 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepineQ: What is 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Q: What is the CAS Number of 11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
  • inhibit,Inhibitor,Muscarinic acetylcholine receptor,hM4Di,Deschloroclozapine,hM3Dq,muscarinic-based,mAChR,DREADDs
  • 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
  • Deschloroclozapine, 10 mM in DMSO
  • (4-Methyl-1-piperazinyl)-5h-dibenzo(b,e)(1,4)diazepine
  • 1977-07-7