4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID
- Product Name
- 4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID
- CAS No.
- 29421-99-6
- Chemical Name
- 4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID
- Synonyms
- AKOS B029947;VITAS-BB TBB010222;ART-CHEM-BB B029947;4-BROMO-5-METHYLTHIOPHENE-2-CARBOXYLIC ACID;4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID;2-Thiophenecarboxylic acid, 4-bromo-5-methyl-
- CBNumber
- CB2133164
- Molecular Formula
- C6H5BrO2S
- Formula Weight
- 221.07
- MOL File
- 29421-99-6.mol
4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID Property
- Melting point:
- 198.5-199.5 °C
- Boiling point:
- 324.3±42.0 °C(Predicted)
- Density
- 1.784±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 3.70±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B814943
- Product name
- 4-bromo-5-methylthiophene-2-carboxylicAcid
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- B814943
- Product name
- 4-bromo-5-methylthiophene-2-carboxylicAcid
- Packaging
- 250mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- FB141707
- Product name
- 4-Bromo-5-methylthiophene-2-carboxylic acid
- Packaging
- 10mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB141707
- Product name
- 4-Bromo-5-methylthiophene-2-carboxylic acid
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FB141707
- Product name
- 4-Bromo-5-methylthiophene-2-carboxylic acid
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
29421-73-6
29421-99-6
a) 27.65 g (108 mmol) of 2-methyl-3,5-dibromothiophene (prepared according to the method of Kano, S. et al, Heterocycles 20(10):2035, 1983) was dissolved in 280 mL of anhydrous tetrahydrofuran and cooled to -78°C. To this solution was added, over a 10-minute period, 54 mL (108 mmol) of a 2 M n-butyllithium in cyclohexane solution. After stirring at -78°C for 20 min, dry carbon dioxide gas was passed into the reaction system for 1.5 hr while the mixture was allowed to warm slowly to room temperature. Upon completion of the reaction, 100 mL of 6N hydrochloric acid was carefully added. The organic and aqueous layers were separated and the aqueous layer was extracted with ether (4 x 50 mL). All organic layers were combined, washed with brine and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 22.4 g (94% yield) of 4-bromo-5-methylthiophene-2-carboxylic acid as an off-white solid.1H-NMR (DMSO-d6; 300 MHz) δ 13.34 (br s, 1H), 7.61 (s, 1H), 2.41 (s, 3H).
References
[1] Patent: US2002/37915, 2002, A1
[2] Patent: US6291514, 2001, B1
[3] Patent: US2002/37915, 2002, A1
[4] Patent: US6291514, 2001, B1
[5] Justus Liebigs Annalen der Chemie, 1934, vol. 513, p. 281,291
4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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