ChemicalBook > CAS DataBase List > 4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID

4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID

Product Name: 4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID
CAS No.: 29421-99-6
Chemical Name: 4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID
Synonyms: AKOS B029947;VITAS-BB TBB010222;ART-CHEM-BB B029947;4-BROMO-5-METHYLTHIOPHENE-2-CARBOXYLIC ACID;4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID;2-Thiophenecarboxylic acid, 4-bromo-5-methyl-
CBNumber: CB2133164
Molecular Formula: C6H5BrO2S
Formula Weight: 221.07
MOL File: 29421-99-6.mol

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4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID Property

Melting point:: 198.5-199.5 °C
Boiling point:: 324.3±42.0 °C(Predicted)
Density: 1.784±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 3.70±0.10(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B814943
Product name: 4-bromo-5-methylthiophene-2-carboxylicAcid
Packaging: 50mg
Price: $90
Updated: 2021/12/16

TRC

Product number: B814943
Product name: 4-bromo-5-methylthiophene-2-carboxylicAcid
Packaging: 250mg
Price: $350
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141707
Product name: 4-Bromo-5-methylthiophene-2-carboxylic acid
Packaging: 250mg
Price: $350
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141707
Product name: 4-Bromo-5-methylthiophene-2-carboxylic acid
Packaging: 10mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141707
Product name: 4-Bromo-5-methylthiophene-2-carboxylic acid
Packaging: 100mg
Price: $250
Updated: 2021/12/16

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4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

29421-73-6

29421-99-6

a) 27.65 g (108 mmol) of 2-methyl-3,5-dibromothiophene (prepared according to the method of Kano, S. et al, Heterocycles 20(10):2035, 1983) was dissolved in 280 mL of anhydrous tetrahydrofuran and cooled to -78°C. To this solution was added, over a 10-minute period, 54 mL (108 mmol) of a 2 M n-butyllithium in cyclohexane solution. After stirring at -78°C for 20 min, dry carbon dioxide gas was passed into the reaction system for 1.5 hr while the mixture was allowed to warm slowly to room temperature. Upon completion of the reaction, 100 mL of 6N hydrochloric acid was carefully added. The organic and aqueous layers were separated and the aqueous layer was extracted with ether (4 x 50 mL). All organic layers were combined, washed with brine and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 22.4 g (94% yield) of 4-bromo-5-methylthiophene-2-carboxylic acid as an off-white solid.1H-NMR (DMSO-d6; 300 MHz) δ 13.34 (br s, 1H), 7.61 (s, 1H), 2.41 (s, 3H).

References

[1] Patent: US2002/37915, 2002, A1
[2] Patent: US6291514, 2001, B1
[3] Patent: US2002/37915, 2002, A1
[4] Patent: US6291514, 2001, B1
[5] Justus Liebigs Annalen der Chemie, 1934, vol. 513, p. 281,291

4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID Suppliers

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29421-99-6, 4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACIDRelated Search:

5-Methyl-2-thiophenecarboxylic acid 2-Thiophenecarboxylic acid 4-BROMO-5-ETHYL-THIOPHENE-2-CARBOXYLIC ACID 4-Bromo-5-(1,1-dimethylethyl)-2-thiophenecarboxylicacid 4-BROMO-5-PROPYLTHIOPHENE-2-CARBOXYLIC ACID 4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID methyl 4-bromo-5-formyl-2-thiophenecarboxylate 4-BROMO-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID

4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID

4-BROMO-5-METHYLTHIOPHENE-2-CARBOXYLIC ACID

AKOS B029947

ART-CHEM-BB B029947

VITAS-BB TBB010222

2-Thiophenecarboxylic acid, 4-bromo-5-methyl-

29421-99-6