2-amino-4-phosphonobutyric acid

Product Name: 2-amino-4-phosphonobutyric acid
CAS No.: 6323-99-5
Chemical Name: 2-amino-4-phosphonobutyric acid
Synonyms: 2-Amino-4-phosphonobutanoic acid;Butanoic acid, 2-amino-4-phosphono-;DL-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)
CBNumber: CB21333718
Molecular Formula: C4H10NO5P
Formula Weight: 183.1
MOL File: 6323-99-5.mol

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2-amino-4-phosphonobutyric acid Property

Melting point:: 229-231 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point:: 491.7±55.0 °C(Predicted)
Density: 1.628±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Water:9.15(Max Conc. mg/mL);50.0(Max Conc. mM)
form: White solid.
pka: 2.19±0.10(Predicted)
color: White to off-white
Water Solubility: Soluble to 50 mM in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29011
Product name: DL-AP4
Packaging: 50mg
Price: $39
Updated: 2024/03/01

Cayman Chemical

Product number: 29011
Product name: DL-AP4
Packaging: 100mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 29011
Product name: DL-AP4
Packaging: 250mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 29011
Product name: DL-AP4
Packaging: 500mg
Price: $322
Updated: 2024/03/01

TRC

Product number: A627558
Product name: DL-2-Amino-4-phosphonobutanoicacid(AP4)
Packaging: 10mg
Price: $420
Updated: 2021/12/16

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2-amino-4-phosphonobutyric acid Chemical Properties,Usage,Production

Description

DL-AP4 is a broad-spectrum glutamatergic antagonist. DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA , L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM. DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate , quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.

Uses

DL-2-Amino-4-phosphonobutanoic acid (AP4) is an amino-acid derivative reported to block cone signals in the rat retina. Improves learning and memory processes in passive and active avoidance situations in rats.

storage

Store at RT

References

[1] W. FROST WHITE. Glutamate as transmitter of hippocampal perforant path[J]. Nature, 1977, 270 5635: 356-357. DOI: 10.1038/270356a0
[2] R.H. EVANS. ANTAGONISM OF EXCITATORY AMINO ACID-INDUCED RESPONSES AND OF SYNAPTIC EXCITATION IN THE ISOLATED SPINAL CORD OF THE FROG[J]. British Journal of Pharmacology, 1979, 67 4: 591-603. DOI: 10.1111/j.1476-5381.1979.tb08706.x
[3] F. NICOLETTI. Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus[J]. Journal of Neurochemistry, 1986, 46 1: 40-46. DOI: 10.1111/j.1471-4159.1986.tb12922.x

2-amino-4-phosphonobutyric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-amino-4-phosphonobutyric acid Suppliers

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2-Amino-4-phosphonobutanoic acid

DL-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)

Butanoic acid, 2-amino-4-phosphono-

6323-99-5