D-AP5

Product Name: D-AP5
CAS No.: 79055-68-8
Chemical Name: D-AP5
Synonyms: EIF4G2;D-AP5;IF4G2;D-APV;(R)-AP-5;Emasol L10;Emasol L 10;Emasol L-10;D-AP5(mM/ml);D-AP5 ，E1246
CBNumber: CB3371309
Molecular Formula: C5H12NO5P
Formula Weight: 197.13
MOL File: 79055-68-8.mol

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D-AP5 Property

Melting point:: approximate 233℃
Boiling point:: 482.1±55.0 °C(Predicted)
Density: 1.529±0.06 g/cm3(Predicted)
RTECS: RD2513000
storage temp.: Store at RT
solubility: Soluble to 100 mM in sterile
form: White solid
pka: 2.46±0.10(Predicted)
color: White
Water Solubility: Soluble in water (100mM)
Sensitive: Light Sensitive

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A8054
Product name: D(?)-2-Amino-5-phosphonopentanoic acid
Purity: NMDA receptor antagonist
Packaging: 1mg
Price: $93.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 165304
Product name: D-(–)-2-Amino-5-phosphonopentanoic Acid
Packaging: 5mg
Price: $180
Updated: 2025/07/31

Cayman Chemical

Product number: 14539
Product name: D-AP5
Purity: ≥95%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 14539
Product name: D-AP5
Purity: ≥95%
Packaging: 10mg
Price: $100
Updated: 2024/03/01

Sigma-Aldrich

Product number: A8054
Product name: D(?)-2-Amino-5-phosphonopentanoic acid
Purity: NMDA receptor antagonist
Packaging: 5mg
Price: $273
Updated: 2025/07/31

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D-AP5 Chemical Properties,Usage,Production

Description

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (K_d = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.

Chemical Properties

white fine crystalline powder

Uses

A competitive NMDA antagonist

General Description

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist.

Biological Activity

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Product does not compete with ATP.

storage

Room temperature

References

[1] MORRIS R G. Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5.[J]. Journal of Neuroscience, 1989, 9 9: 3040-3057.

D-AP5 Preparation Products And Raw materials

Raw materials

Preparation Products

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D-AP5 Suppliers

China 143 Germany 2 Japan 3 Switzerland 2 United Kingdom 7 United States 18 Global 175

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
ProdList: 279
Advantage: 60

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Shanghai ChuangYan Chemical Technology Co., Ltd.

Tel: 021-11111111 11111111111
Fax: qq:546919421
Email: 546919421@qq.com
Country: China
ProdList: 3519
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

79055-68-8, D-AP5Related Search:

12AP ANTI-IGM MU-CHAIN, RAT AP CONJ ANTI-IGG H AND L CHAIN, GOAT AP CONJ DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID D-AP5 5-PHOSPHONOPENTANOIC ACID 4-AMINOBUTYLPHOSPHONIC ACID ANTI-IGG GAMMA-CHAIN, HUMAN AP CONJ ANTI-IGG, HUMAN AP CONJ ANTI-IMMUNOGLOBULIN A, HUMAN, AP ANTI-IGG, MOUSE AP CONJ 16-AP ANTI-IGG(H+L), HUMAN AP CONJ,ANTI-IGG H AND L CHAIN, HUMAN AP CONJ ANTI-IGG(H+L), RABBIT AP CONJ,ANTI-IGG H AND L CHAIN, RABBIT AP CONJ ANTI-IMMUNOGLOBULIN G, BOVINE, F(AB')2, AP ANTI-IGG H AND L CHAIN, HORSE AP CONJ ANTI-IMMUNOGLOBULIN G, CAT, F(AB')2, AP ANTI-IGM MU-CHAIN, HUMAN AP CONJ

D-AP5

D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID

D-2-AMINO-5-PHOSPHONOPENTANOIC ACID

D-(-)-2-AMINO-5-PHOSPHONOVALERIC ACID

D(-)-2-Amino-5-phosphonovaleric acid hydrate

D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID (D-AP5)

D-(–)-2-Amino-5-phosphonopentanoic Acid - CAS 79055-68-8 - Calbiochem

D(-)-AP-5, D(-)-APV, D-2-Amino-5-phosphonovaleric acid

(R)-2-aMino-5-phosphonopentanoic acid

(2R)-2-aMMonio-5-phosphonatopentanoate

Anti-EIF4G2, N-Terminal antibody produced in rabbit

Death associated protein 5

EIF4G2

Eukaryotic translation initiation factor 4 γ 2

IF4G2

D(-)-2-Amino-5-phosphonovaleric acid (D-AP5)

(2R)-2-Amino-5-phosphonovaleric acid

(R)-2-Amino-5-phosphonovaleric acid

(R)-5-Phosphono-2-aminovaleric acid

(R)-AP-5

D-APV

D(-)-2-Amino-5-phosphonovaleric acid hydrate,96%, (>98% ee)

D(-)-2-AMINO-5-PHOSPHONOPENTANOIC AC

5-Phosphono-D-norvaline

D(-)-2-AMINO-5-PHOSPHONOVALERIC ACID (D-AP5);5-PHOSPHONO-D-NORVALINE

D-Norvaline, 5-phosphono-

Emasol L 10

Emasol L10

Emasol L-10

(-)-2-Amino-5-phosphonovaleric acid

D-APV|||D-2-Amino-5-phosphonovaleric acid

D-AP5(mM/ml)

D-AP5, NMDA glutamate site antagonist

D-AP5 (mM/ml), NMDA glutamate site antagonist

D-AP5, 10 mM in DMSO

<sc>D</sc>(?)-2-Amino-5-phosphonopentanoic acid

D-AP5 ，E1246

D-AP5 (Synonyms: D-APV

79055-68-8

C5H12NO5P

Glutamate

Glutamate receptor