ChemicalBook > CAS DataBase List > D-AP5

D-AP5

Product Name
D-AP5
CAS No.
79055-68-8
Chemical Name
D-AP5
Synonyms
EIF4G2;D-AP5;IF4G2;D-APV;(R)-AP-5;Emasol L10;Emasol L 10;Emasol L-10;5-Phosphono-D-norvaline;D-Norvaline, 5-phosphono-
CBNumber
CB3371309
Molecular Formula
C5H12NO5P
Formula Weight
197.13
MOL File
79055-68-8.mol
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D-AP5 Property

Melting point:
approximate 233℃
Boiling point:
482.1±55.0 °C(Predicted)
Density 
1.529±0.06 g/cm3(Predicted)
RTECS 
RD2513000
storage temp. 
Store at RT
solubility 
Soluble to 100 mM in sterile
form 
White solid
pka
2.46±0.10(Predicted)
color 
White
Water Solubility 
Soluble in water (100mM)
Sensitive 
Light Sensitive
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8054
Product name
D(?)-2-Amino-5-phosphonopentanoic acid
Purity
NMDA receptor antagonist
Packaging
1mg
Price
$91.3
Updated
2024/03/01
Sigma-Aldrich
Product number
165304
Product name
D-(–)-2-Amino-5-phosphonopentanoic Acid
Packaging
5mg
Price
$166
Updated
2024/03/01
Alfa Aesar
Product number
J64887
Product name
(R)-(-)-2-Amino-5-phosphonopentanoic acid, 99%
Packaging
10mg
Price
$325
Updated
2024/03/01
Cayman Chemical
Product number
14539
Product name
D-AP5
Purity
≥95%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
14539
Product name
D-AP5
Purity
≥95%
Packaging
10mg
Price
$100
Updated
2024/03/01
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D-AP5 Chemical Properties,Usage,Production

Description

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.

Chemical Properties

white fine crystalline powder

Uses

A competitive NMDA antagonist

General Description

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist.

Biological Activity

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Product does not compete with ATP.

storage

Room temperature

D-AP5 Preparation Products And Raw materials

Raw materials

Preparation Products

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D-AP5 Suppliers

China 101 Germany 2 Japan 3 Switzerland 2 United Kingdom 7 United States 16 Global 131
3B Pharmachem (Wuhan) International Co.,Ltd.
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79055-68-8, D-AP5Related Search:

12AP ANTI-IGM MU-CHAIN, RAT AP CONJ ANTI-IGG H AND L CHAIN, GOAT AP CONJ DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID D-AP5 5-PHOSPHONOPENTANOIC ACID 4-AMINOBUTYLPHOSPHONIC ACID ANTI-IGG GAMMA-CHAIN, HUMAN AP CONJ ANTI-IGG, HUMAN AP CONJ ANTI-IMMUNOGLOBULIN A, HUMAN, AP ANTI-IGG, MOUSE AP CONJ 16-AP ANTI-IGG(H+L), HUMAN AP CONJ,ANTI-IGG H AND L CHAIN, HUMAN AP CONJ ANTI-IGG(H+L), RABBIT AP CONJ,ANTI-IGG H AND L CHAIN, RABBIT AP CONJ ANTI-IMMUNOGLOBULIN G, BOVINE, F(AB')2, AP ANTI-IGG H AND L CHAIN, HORSE AP CONJ ANTI-IMMUNOGLOBULIN G, CAT, F(AB')2, AP ANTI-IGM MU-CHAIN, HUMAN AP CONJ

  • D-AP5
  • D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID
  • D-2-AMINO-5-PHOSPHONOPENTANOIC ACID
  • D-(-)-2-AMINO-5-PHOSPHONOVALERIC ACID
  • D(-)-2-Amino-5-phosphonovaleric acid hydrate
  • D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID (D-AP5)
  • D-(–)-2-Amino-5-phosphonopentanoic Acid - CAS 79055-68-8 - Calbiochem
  • D(-)-AP-5, D(-)-APV, D-2-Amino-5-phosphonovaleric acid
  • (R)-2-aMino-5-phosphonopentanoic acid
  • (2R)-2-aMMonio-5-phosphonatopentanoate
  • Anti-EIF4G2, N-Terminal antibody produced in rabbit
  • Death associated protein 5
  • EIF4G2
  • Eukaryotic translation initiation factor 4 γ 2
  • IF4G2
  • D(-)-2-Amino-5-phosphonovaleric acid (D-AP5)
  • (2R)-2-Amino-5-phosphonovaleric acid
  • (R)-2-Amino-5-phosphonovaleric acid
  • (R)-5-Phosphono-2-aminovaleric acid
  • (R)-AP-5
  • D-APV
  • D(-)-2-Amino-5-phosphonovaleric acid hydrate,96%, (>98% ee)
  • D(-)-2-AMINO-5-PHOSPHONOPENTANOIC AC
  • 5-Phosphono-D-norvaline
  • D(-)-2-AMINO-5-PHOSPHONOVALERIC ACID (D-AP5);5-PHOSPHONO-D-NORVALINE
  • D-Norvaline, 5-phosphono-
  • Emasol L 10
  • Emasol L10
  • Emasol L-10
  • (-)-2-Amino-5-phosphonovaleric acid
  • 79055-68-8
  • C5H12NO5P
  • Glutamate
  • Glutamate receptor