ChemicalBook > CAS DataBase List > D-AP5

D-AP5

Product Name
D-AP5
CAS No.
79055-68-8
Chemical Name
D-AP5
Synonyms
EIF4G2;D-AP5;IF4G2;D-APV;(R)-AP-5;Emasol L10;Emasol L 10;Emasol L-10;D-AP5(mM/ml);5-Phosphono-D-norvaline
CBNumber
CB3371309
Molecular Formula
C5H12NO5P
Formula Weight
197.13
MOL File
79055-68-8.mol
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D-AP5 Property

Melting point:
approximate 233℃
Boiling point:
482.1±55.0 °C(Predicted)
Density 
1.529±0.06 g/cm3(Predicted)
RTECS 
RD2513000
storage temp. 
Store at RT
solubility 
Soluble to 100 mM in sterile
form 
White solid
pka
2.46±0.10(Predicted)
color 
White
Water Solubility 
Soluble in water (100mM)
Sensitive 
Light Sensitive
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8054
Product name
D(?)-2-Amino-5-phosphonopentanoic acid
Purity
NMDA receptor antagonist
Packaging
1mg
Price
$91.3
Updated
2024/03/01
Sigma-Aldrich
Product number
165304
Product name
D-(–)-2-Amino-5-phosphonopentanoic Acid
Packaging
5mg
Price
$166
Updated
2024/03/01
Alfa Aesar
Product number
J64887
Product name
(R)-(-)-2-Amino-5-phosphonopentanoic acid, 99%
Packaging
10mg
Price
$325
Updated
2024/03/01
Cayman Chemical
Product number
14539
Product name
D-AP5
Purity
≥95%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
14539
Product name
D-AP5
Purity
≥95%
Packaging
10mg
Price
$100
Updated
2024/03/01
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D-AP5 Chemical Properties,Usage,Production

Description

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.

Chemical Properties

white fine crystalline powder

Uses

A competitive NMDA antagonist

General Description

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist.

Biological Activity

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Product does not compete with ATP.

storage

Room temperature

D-AP5 Preparation Products And Raw materials

Raw materials

Preparation Products

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D-AP5 Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
Country
United Kingdom
ProdList
279
Advantage
60
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai ChuangYan Chemical Technology Co., Ltd.
Tel
021-11111111 11111111111
Fax
qq:546919421
Email
546919421@qq.com
Country
China
ProdList
3217
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60

79055-68-8, D-AP5Related Search:


  • D-AP5
  • D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID
  • D-2-AMINO-5-PHOSPHONOPENTANOIC ACID
  • D-(-)-2-AMINO-5-PHOSPHONOVALERIC ACID
  • D(-)-2-Amino-5-phosphonovaleric acid hydrate
  • D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID (D-AP5)
  • D-(–)-2-Amino-5-phosphonopentanoic Acid - CAS 79055-68-8 - Calbiochem
  • D(-)-AP-5, D(-)-APV, D-2-Amino-5-phosphonovaleric acid
  • (R)-2-aMino-5-phosphonopentanoic acid
  • (2R)-2-aMMonio-5-phosphonatopentanoate
  • Anti-EIF4G2, N-Terminal antibody produced in rabbit
  • Death associated protein 5
  • EIF4G2
  • Eukaryotic translation initiation factor 4 γ 2
  • IF4G2
  • D(-)-2-Amino-5-phosphonovaleric acid (D-AP5)
  • (2R)-2-Amino-5-phosphonovaleric acid
  • (R)-2-Amino-5-phosphonovaleric acid
  • (R)-5-Phosphono-2-aminovaleric acid
  • (R)-AP-5
  • D-APV
  • D(-)-2-Amino-5-phosphonovaleric acid hydrate,96%, (>98% ee)
  • D(-)-2-AMINO-5-PHOSPHONOPENTANOIC AC
  • 5-Phosphono-D-norvaline
  • D(-)-2-AMINO-5-PHOSPHONOVALERIC ACID (D-AP5);5-PHOSPHONO-D-NORVALINE
  • D-Norvaline, 5-phosphono-
  • Emasol L 10
  • Emasol L10
  • Emasol L-10
  • (-)-2-Amino-5-phosphonovaleric acid
  • D-APV|||D-2-Amino-5-phosphonovaleric acid
  • D-AP5(mM/ml)
  • 79055-68-8
  • C5H12NO5P
  • Glutamate
  • Glutamate receptor