L-701,252

Product Name: L-701,252
CAS No.: 151057-13-5
Chemical Name: L-701,252
Synonyms: L-701,252;L-701252, 10 mM in DMSO;7-CHLORO-3-(CYCLOPROPYL-CARBONYL)-4-HYDROXY-2(1H)-QUINOLINE;7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINONE;7-Chloro-3-(cyclopropanecarbonyl)-4-hydroxyquinolin-2(1H)-one;2(1H)-Quinolinone, 7-chloro-3-(cyclopropylcarbonyl)-4-hydroxy-;7-chloro-3-[cyclopropyl(oxo)methyl]-2-hydroxy-1H-quinolin-4-one;7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINE[L-701, 252]
CBNumber: CB0248389
Molecular Formula: C13H10ClNO3
Formula Weight: 263.68
MOL File: 151057-13-5.mol

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L-701,252 Property

Boiling point:: 516.8±50.0 °C(Predicted)
Density: 1.573±0.06 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: Soluble to 50 mM in DMSO
form: White crystalline solid.
pka: 4.50±1.00(Predicted)
color: White to off-white
InChI: InChI=1S/C13H10ClNO3/c14-7-3-4-8-9(5-7)15-13(18)10(12(8)17)11(16)6-1-2-6/h3-6H,1-2H2,(H2,15,17,18)
InChIKey: MXEFWCFPCLDOOG-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(Cl)=C2)C(O)=C(C(C2CC2)=O)C1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 0705
Product name: L-701,252
Purity: ≥99%(HPLC)
Packaging: 10
Price: $128
Updated: 2021/12/16

Tocris

Product number: 0705
Product name: L-701,252
Purity: ≥99%(HPLC)
Packaging: 50
Price: $538
Updated: 2021/12/16

TRC

Product number: L009513
Product name: L-701,252
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ApexBio Technology

Product number: B6411
Product name: L-701,252
Packaging: 10mg
Price: $219
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007690
Product name: L-701252
Purity: 95.00%
Packaging: 10MG
Price: $324.45
Updated: 2021/12/16

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L-701,252 Chemical Properties,Usage,Production

Uses

L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1].

Definition

ChEBI: 7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one is a quinolone and a hydroxyquinoline.

Biological Activity

An antagonist at the glycine-NMDA site (IC 50 = 420 nM). Also a potent systemic anticonvulsant.

in vivo

L-701252 (50 mg/kg; i.p.) provides a small non-significant protection^[1].

Animal Model:	3-Months Male Mongolian gerbils (60 g)^[1]
Dosage:	50 mg/kg
Administration:	i.p.
Result:	Provided a small non-significant protection.

IC 50

NMDA Receptor

storage

Desiccate at +4°C

References

[1] Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. DOI:10.1016/s0165-6147(00)01451-6
[2] Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242. DOI:10.1016/s0006-8993(96)00779-2

L-701,252 Preparation Products And Raw materials

Raw materials

Preparation Products

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L-701,252 Suppliers

China 26 Europe 1 Germany 3 United Kingdom 5 United States 8 USA 1 Global 44

Wuhan Topule

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151057-13-5, L-701,252Related Search:

DL-2-AMINO-5-PHOSPHONOPENTANOIC ACID D-AP5 2-amino-4-phosphonobutyric acid 5,7-DICHLOROKYNURENIC ACID SODIUM SALT O-Phospho-L-serine N-Methyl-D-aspartic acid Cycloleucine Quinolinic acid Spermidine trihydrochloride (R)-CPP Synthalin sulfate Licostinel N-Phenyl-isobutyloylacetamide N-(5-CHLORO-2-METHYL-PHENYL)-3-OXO-BUTYRAMIDE 4-Nitropyrazole 7-Chloro-2-hydroxyquinoline 3'-chloroacetoacetanilide L-701,252

L-701,252

7-CHLORO-3-(CYCLOPROPYL-CARBONYL)-4-HYDROXY-2(1H)-QUINOLINE

7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINONE

7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINE[L-701, 252]

7-Chloro-3-(cyclopropanecarbonyl)-4-hydroxyquinolin-2(1H)-one

7-chloro-3-[cyclopropyl(oxo)methyl]-2-hydroxy-1H-quinolin-4-one

2(1H)-Quinolinone, 7-chloro-3-(cyclopropylcarbonyl)-4-hydroxy-

L-701252, 10 mM in DMSO

151057-13-5

Glutamate receptor