L-701,252

Product Name: L-701,252
CAS No.: 151057-13-5
Chemical Name: L-701,252
Synonyms: L-701,252;L-701252, 10 mM in DMSO;7-CHLORO-3-(CYCLOPROPYL-CARBONYL)-4-HYDROXY-2(1H)-QUINOLINE;7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINONE;7-Chloro-3-(cyclopropanecarbonyl)-4-hydroxyquinolin-2(1H)-one;2(1H)-Quinolinone, 7-chloro-3-(cyclopropylcarbonyl)-4-hydroxy-;7-chloro-3-[cyclopropyl(oxo)methyl]-2-hydroxy-1H-quinolin-4-one;7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINE[L-701, 252]
CBNumber: CB0248389
Molecular Formula: C13H10ClNO3
Formula Weight: 263.68
MOL File: 151057-13-5.mol

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L-701,252 Property

Boiling point:: 516.8±50.0 °C(Predicted)
Density: 1.573±0.06 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: Soluble to 50 mM in DMSO
form: White crystalline solid.
pka: 4.50±1.00(Predicted)
color: White to off-white
InChI: InChI=1S/C13H10ClNO3/c14-7-3-4-8-9(5-7)15-13(18)10(12(8)17)11(16)6-1-2-6/h3-6H,1-2H2,(H2,15,17,18)
InChIKey: MXEFWCFPCLDOOG-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(Cl)=C2)C(O)=C(C(C2CC2)=O)C1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 0705
Product name: L-701,252
Purity: ≥99%(HPLC)
Packaging: 10
Price: $128
Updated: 2021/12/16

Tocris

Product number: 0705
Product name: L-701,252
Purity: ≥99%(HPLC)
Packaging: 50
Price: $538
Updated: 2021/12/16

TRC

Product number: L009513
Product name: L-701,252
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ApexBio Technology

Product number: B6411
Product name: L-701,252
Packaging: 10mg
Price: $219
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007690
Product name: L-701252
Purity: 95.00%
Packaging: 10MG
Price: $324.45
Updated: 2021/12/16

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L-701,252 Chemical Properties,Usage,Production

Uses

L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1].

Definition

ChEBI: 7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one is a quinolone and a hydroxyquinoline.

Biological Activity

An antagonist at the glycine-NMDA site (IC 50 = 420 nM). Also a potent systemic anticonvulsant.

in vivo

L-701252 (50 mg/kg; i.p.) provides a small non-significant protection^[1].

Animal Model:	3-Months Male Mongolian gerbils (60 g)^[1]
Dosage:	50 mg/kg
Administration:	i.p.
Result:	Provided a small non-significant protection.

IC 50

NMDA Receptor

storage

Desiccate at +4°C

References

[1] Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. DOI:10.1016/s0165-6147(00)01451-6
[2] Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242. DOI:10.1016/s0006-8993(96)00779-2

L-701,252 Preparation Products And Raw materials

Raw materials

Preparation Products

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L-701,252 Suppliers

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151057-13-5, L-701,252Related Search:

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L-701,252

7-CHLORO-3-(CYCLOPROPYL-CARBONYL)-4-HYDROXY-2(1H)-QUINOLINE

7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINONE

7-CHLORO-3-(CYCLOPROPYLCARBONYL)-4-HYDROXY-2(1H)-QUINOLINE[L-701, 252]

7-Chloro-3-(cyclopropanecarbonyl)-4-hydroxyquinolin-2(1H)-one

7-chloro-3-[cyclopropyl(oxo)methyl]-2-hydroxy-1H-quinolin-4-one

2(1H)-Quinolinone, 7-chloro-3-(cyclopropylcarbonyl)-4-hydroxy-

L-701252, 10 mM in DMSO

151057-13-5

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