ChemicalBook > CAS DataBase List > 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

Product Name
1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
CAS No.
6001-64-5
Chemical Name
1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
Synonyms
MET;CHLOROBUTANOL HEMIHYDRATE;CHLORETONE;CHLOROBUTANOL HYDROUS;CHLORBUTE;CHLORBUTOL;MET HEMIHYDRATE;ACETONE CHLOROFORM;Chlorobutanol Base;ACETONE CHLOROFORME
CBNumber
CB2134363
Molecular Formula
C8H16Cl6O3
Formula Weight
372.93
MOL File
6001-64-5.mol
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1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Property

Melting point:
77-79 °C(lit.)
Boiling point:
173-175 °C
Flash point:
100 °C
storage temp. 
2-8°C
solubility 
Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent).
form 
Crystalline Powder, Crystals and/or Chunks
color 
White to almost white
Water Solubility 
Soluble in ethanol, ether, chloroform, and glycerol. Insoluble in water.
Merck 
14,2129
BRN 
878167
Stability:
Stable. Generates toxic fumes on combustion. Incompatible with strong oxidizing agents.
LogP
2.074 (est)
CAS DataBase Reference
6001-64-5
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
RTECS 
UC0175000
TSCA 
Yes
HS Code 
29055900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB1305534
Product name
MONOCLONAL ANTI-BI-PHOSPHO-MET/HGFR(Y1234/Y1235) antibody produced in mouse
Purity
clone 6AT1877, IgG fraction of antiserum, buffered aqueous solution
Packaging
400μl
Price
$481
Updated
2024/03/01
Sigma-Aldrich
Product number
112054
Product name
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate
Purity
98%
Packaging
50g
Price
$57
Updated
2024/03/01
Sigma-Aldrich
Product number
1112503
Product name
Chlorobutanol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$491
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0002029
Product name
Chlorobutanol hemihydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002029
Price
$150
Updated
2023/01/07
Sigma-Aldrich
Product number
1.01005
Product name
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate
Purity
EMPROVE? ESSENTIAL, Ph. Eur., BP, JP, NF
Packaging
1KG
Price
$221
Updated
2022/05/15
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1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Chemical Properties,Usage,Production

Chemical Properties

white crystalline solid

Uses

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate in combination with dimethyl sulfone, can serve as an appropriate solvent for the freeze drying of certain parenteral organic drugs, which have an increase in many factors such as stability, dissolution rate, dosing accuracy and sterility.

Uses

Pharmaceutic aid (antimicrobial agent).

Uses

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate converts benzisoxazole to α-aryloxyisobutyric acid. It forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.

brand name

Chloretone (Parke-Davis).

General Description

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) converts benzisoxazole to α-aryloxyisobutyric acid. 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.

Biochem/physiol Actions

Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol is a opthalmic preservative and sedative hypnotic that possess antibacterial and antifungal properties. It also decreases the conduction velocity and induces conduction failure and automaticity within isolated ventricular muscle strips as well as impacts myocardial cells by acting on cell membrane and reduces isometric tension produced by heart.

1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Suppliers

Belgium 2 Brazil 1 China 186 France 2 Germany 6 India 34 Japan 4 Latvia 2 Poland 1 Switzerland 3 The Netherlands 1 United Arab Emirates 1 United Kingdom 7 United States 32 Global 282
HPC Standards GmbH
Tel
--
Fax
--
Email
chulze@hpc-standards.com
Country
Germany
ProdList
2139
Advantage
58
Merck Millipore
Tel
--
Fax
--
Email
ccc@merckgroup.com
Country
Germany
ProdList
2008
Advantage
58
Dr. Ehrenstorfer GmbH
Tel
--
Fax
--
Email
info@analytical-standards.com
Country
Germany
ProdList
5545
Advantage
66
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
Merck Schuchardt OHG
Tel
--
Fax
--
Email
schuchardt-vertrieb@merck.de
Country
Germany
ProdList
5827
Advantage
74
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View Lastest Price from 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Chlorobutanol 6001-64-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%~101.0%
Supply Ability
5000kg/month
Release date
2021-06-18
Hebei Weibang Biotechnology Co., Ltd
Product
1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE 6001-64-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-11
Hebei Weibang Biotechnology Co., Ltd
Product
1,1,1-Trichloro-2-Methyl-2-Propanol Hemihydrate 6001-64-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29

6001-64-5, 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATERelated Search:

2-Methyl-2-butanol 3-Chloro-1-propanol Polymethylhydrosiloxane Methylcyclohexane 2-Amino-2-methyl-1-propanol 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE tert-Butanol Chlorobutanol Chlorobutanol 1,1,1-TRICHLORO-2-PROPANOL (R)-(+)-3-HYDROXY-3-METHYL-4,4,4-TRICHLOROBUTYRIC BETA-LACTONE (S)-(-)-3-HYDROXY-3-METHYL-4,4,4-TRICHLOROBUTYRIC BETA-LACTONE 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HYDRATE BIS(2,2,2-TRICHLORO-1,1-DIMETHYLETHYL) PHOSPHOROCHLORIDATE 2,2,2-TRICHLORO-TERT-BUTOXYCARBONYL HYDRAZIDE SALOR-INT L320064-1EA AKOS 94377

  • CHLOROBUTANOL HEMIHYDRATE
  • CHLOROBUTO HEMIHYDRATE
  • CHLORETONE
  • CHLORETONE 0.5-WATER
  • CHLORETONE HEMIHYDRATE
  • CHLORBUTE
  • CHLORBUTOL
  • BETA,BETA,BETA-TRICHLORO-T-BUTANOL HEMIHYDRATE
  • BETA,BETA,BETA-TRICHLORO-TERT-BUTYL ALCOHOL HEMIHYDRATE
  • Acetonechloroform beta,beta,beta-Trichloro-tert-butyl Alcohol Chloretone
  • Chlorbutanol HeMihydrate
  • MONOCLONAL ANTI-BI-PHOSPHO-MET/HGFR(Y1234/Y1235) antibody produced in mouse
  • Proto-oncogene c-Met
  • Scatter factor receptor
  • 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate 98%
  • 1,1,1-Trichloro-2-methyl-propanol hydrat
  • 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate β,β,β-Trichloro-tert-butyl alcohol hemihydrate Acetone chloroform
  • ACETONE CHLOROFORM
  • 'ACETONE CHLOROFORM'
  • ACETONE CHLOROFORM 0.5-WATER
  • ACETONE CHLOROFORM HEMIHYDRATE
  • ACETONCHLOROFORM HEMIHYDRATE
  • 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HYDRATE
  • 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate,β,β,β-Trichloro-t-butanol, β,β,β-Trichloro-tert-butyl alcohol hemihydrate, Acetone chloroform, Chloretone, Chlorobutanol
  • Chlorobutanol (200 mg)
  • Chlorobutanol, Hydrous, NF
  • 1,1,1-Trichloro-2-Methyl-2-propanol&nbsp
  • 1,1,1-Trichloro-2-Methyl-2-propanol heMihydrate, 98% 100GR
  • 1,1,1-trichloro-2-methyl-2-propanol hemihydrate 2(
  • 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL 0.5-WATER
  • 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
  • 2,2,2-TRICHLORO-TERT BUTYL ALCOHOL
  • TRICHLORO-TER BUTANOL HEMIHYDRATE
  • TRICHLORO-TERT BUTANOL
  • N-METHYL-N-ETHYLTRYPTAMINE
  • > 100 Kghlorobutanol hemihydrate
  • 2-Methyl-1,1,1-trichloro-2-propanol hemihydrate
  • ACETONE CHLOROFORME
  • β,β,β-Trichloro-tert-butyl alcohol hemihydrate
  • CHLOROBUTANOL HEMIHYDRATE, PHARMA
  • 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL 0.5H2O
  • 2-Propanol, 1,1,1-trichloro-2-methyl-, hydrate (2:1)
  • β,β,β-trichloro-t-butanol
  • CHLORBUTOLHEMIHYDRATE
  • CHLOROBUTANOL,HEMIHYDRATE,NF
  • MET
  • MET HEMIHYDRATE
  • CHLOROBUTANOL HYDROUS
  • β,β,β-Trichloro-t-butanol, Acetone chloroform, Chloretone, Chlorobutanol, β,β,β-Trichloro-tert-butyl alcohol hemihydrate
  • Acetone chloroform, Chlorobutanol, β,β,β-Trichloro-tert-butyl alcohol hemihydrate
  • 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate,98%
  • 1,1,1-Trichloro-2-methyl-2-propanol Hemihydrate&gt
  • Chlorobutanol? (pharmaceutical grade)
  • SanlvShudingchunChlorobutanol
  • 6001-64-5 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
  • Chlorobutanol (1112503)
  • β,β,β-Trichloro-tert-butyl alcohol hemihydrate
  • 1,1,1-Trichloro-2-methylpropan-2-ol hydrate