2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether
- Product Name
- 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether
- CAS No.
- 154675-18-0
- Chemical Name
- 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether
- Synonyms
- Hhbpdde;HBDDE, PKCalpha and PKCgamma inhibitor;[1,1'-Biphenyl]-2,2',3,3',4,4'-hexol, 6,6'-bis(methoxymethyl)-
- CBNumber
- CB21355051
- Molecular Formula
- C16H18O8
- Formula Weight
- 338.31
- MOL File
- 154675-18-0.mol
2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Property
- Melting point:
- 165-168℃
- storage temp.
- -20°C
- solubility
- ethanol: 1mg/mL
warm water: 1mg/mL
DMSO: 5mg/mL - form
- Orange solid.
- color
- Brown to khaki
- Sensitive
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- 372770
- Product name
- HBDDE - CAS 154675-18-0 - Calbiochem
- Purity
- A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.
- Packaging
- 1MG
- Price
- $238
- Updated
- 2025/07/31
- Product number
- KIN0000353
- Product name
- HBDDE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $191.1
- Updated
- 2021/12/16
- Product number
- KIN0000353
- Product name
- HBDDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.8
- Updated
- 2021/12/16
2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Chemical Properties,Usage,Production
Uses
HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].
Definition
ChEBI: 5-(methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol is a tannin.
Biological Activity
Cell permeable: yes', 'Primary Target
PKCα', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 43 μM against PKCα
IC 50
PKCα: 43 μM (IC50); PKCγ: 50 μM (IC50)
References
[1] A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15. DOI:10.1016/s0006-2952(00)00398-1
[2] Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195-200. DOI:10.1021/jm00027a025
2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
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