ChemicalBook > CAS DataBase List > LAVENDUSTIN A

LAVENDUSTIN A

Product Name
LAVENDUSTIN A
CAS No.
125697-92-9
Chemical Name
LAVENDUSTIN A
Synonyms
RG14355;NSC 678027;LAVENDUSTIN A;Lavendustin A,98%;RG-14355;NSC 678027;LAVENDUSTIN A USP/EP/BP;Lavendustin A - CAS 125697-92-9 - Calbiochem;5-AMINO-[(N-2,5-DIHYDROXYBENZYL)-N'-2-HYDROXYBENZYL]SALICYLIC ACID;5-[(2,5-Dihydroxybenzyl)(2-hydroxybenzyl)amino]-2-hydroxybenzoic acid;5-[[(2,5-DIHYDROXYPHENYL)METHYL][(2-HYDROXYPHENYL)METHYL]AMINO]-2-HYDROXYBENZOIC ACID
CBNumber
CB2135704
Molecular Formula
C21H19NO6
Formula Weight
381.38
MOL File
125697-92-9.mol
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LAVENDUSTIN A Property

Melting point:
205-215 °C
Boiling point:
741.7±60.0 °C(Predicted)
Density 
1.495±0.06 g/cm3(Predicted)
RTECS 
DG8578950
storage temp. 
−20°C
solubility 
DMSO: soluble
form 
crystalline
pka
2.31±0.10(Predicted)
color 
Yellow to brown
Sensitive 
Air Sensitive
Stability:
Moisture Sensitive: Hygroscopic
CAS DataBase Reference
125697-92-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26
WGK Germany 
3
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
428150
Product name
Lavendustin A
Packaging
1mg
Price
$216
Updated
2024/03/01
Alfa Aesar
Product number
J67494
Product name
Lavendustin A
Packaging
1mg
Price
$171
Updated
2021/12/16
Cayman Chemical
Product number
10010268
Product name
Lavendustin A
Purity
≥95%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
10010268
Product name
Lavendustin A
Purity
≥95%
Packaging
5mg
Price
$179
Updated
2024/03/01
Cayman Chemical
Product number
10010268
Product name
Lavendustin A
Purity
≥95%
Packaging
10mg
Price
$317
Updated
2024/03/01
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LAVENDUSTIN A Chemical Properties,Usage,Production

Description

Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.

Chemical Properties

Off-White Solid

Uses

A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.

Definition

ChEBI: 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid is an aromatic amine.

Biological Activity

Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M).

target

EGFR | PKC | PI3K | Calcium Channel

LAVENDUSTIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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125697-92-9, LAVENDUSTIN ARelated Search:


  • RG14355
  • LAVENDUSTIN A
  • 5-AMINO-[(N-2,5-DIHYDROXYBENZYL)-N'-2-HYDROXYBENZYL]SALICYLIC ACID
  • 5-[[(2,5-DIHYDROXYPHENYL)METHYL][(2-HYDROXYPHENYL)METHYL]AMINO]-2-HYDROXYBENZOIC ACID
  • Lavendustin A - CAS 125697-92-9 - Calbiochem
  • RG-14355;NSC 678027
  • 5-[(2,5-Dihydroxybenzyl)(2-hydroxybenzyl)amino]-2-hydroxybenzoic acid
  • Lavendustin A,98%
  • NSC 678027
  • Benzoic acid,5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-
  • LAVENDUSTIN A USP/EP/BP
  • 125697-92-9
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors
  • Tyrosine Kinase (TK)
  • Miscellaneous Natural Products
  • All Inhibitors
  • Inhibitors
  • Tyrosine Kinase Inhibitors