LAVENDUSTIN A
- Product Name
- LAVENDUSTIN A
- CAS No.
- 125697-92-9
- Chemical Name
- LAVENDUSTIN A
- Synonyms
- RG14355;NSC 678027;LAVENDUSTIN A;Lavendustin A,98%;RG-14355;NSC 678027;LAVENDUSTIN A USP/EP/BP;Lavendustin A - CAS 125697-92-9 - Calbiochem;5-AMINO-[(N-2,5-DIHYDROXYBENZYL)-N'-2-HYDROXYBENZYL]SALICYLIC ACID;5-[(2,5-Dihydroxybenzyl)(2-hydroxybenzyl)amino]-2-hydroxybenzoic acid;5-[[(2,5-DIHYDROXYPHENYL)METHYL][(2-HYDROXYPHENYL)METHYL]AMINO]-2-HYDROXYBENZOIC ACID
- CBNumber
- CB2135704
- Molecular Formula
- C21H19NO6
- Formula Weight
- 381.38
- MOL File
- 125697-92-9.mol
LAVENDUSTIN A Property
- Melting point:
- 205-215 °C
- Boiling point:
- 741.7±60.0 °C(Predicted)
- Density
- 1.495±0.06 g/cm3(Predicted)
- RTECS
- DG8578950
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- crystalline
- pka
- 2.31±0.10(Predicted)
- color
- Yellow to brown
- Sensitive
- Air Sensitive
- Stability:
- Moisture Sensitive: Hygroscopic
- CAS DataBase Reference
- 125697-92-9(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- 428150
- Product name
- Lavendustin A
- Packaging
- 1mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- J67494
- Product name
- Lavendustin A
- Packaging
- 1mg
- Price
- $171
- Updated
- 2021/12/16
- Product number
- 10010268
- Product name
- Lavendustin A
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 10010268
- Product name
- Lavendustin A
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 10010268
- Product name
- Lavendustin A
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $317
- Updated
- 2024/03/01
LAVENDUSTIN A Chemical Properties,Usage,Production
Description
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.
Chemical Properties
Off-White Solid
Uses
A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.
Definition
ChEBI: 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid is an aromatic amine.
Biological Activity
Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M).
target
EGFR | PKC | PI3K | Calcium Channel
LAVENDUSTIN A Preparation Products And Raw materials
Raw materials
Preparation Products
LAVENDUSTIN A Suppliers
- Tel
- --
- Fax
- --
- reag-info@gms.kanto.co.jp
- Country
- Japan
- ProdList
- 6756
- Advantage
- 74