physalin B

Product Name: physalin B
CAS No.: 23133-56-4
Chemical Name: physalin B
Synonyms: NSC-287088;physalin B;Physalin B, 10 mM in DMSO;(16S,25S)-14α,17α:14,27-Diepoxy-13,20,22α-trihydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5-diene-18,26-dioic acid 18,20:26,22-dilactone;(16S,22R,25S)-14α,17α:14,27-Diepoxy-13,20,22-trihydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5-diene-18,26-dioic acid 18,20:26,22-dilactone;17,3-(Epoxymethano)-1,17:2,6-dimethano-17H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,21(1H,8aH,10bH)-tetrone, 2,3,6,6a,9,10,10a,14,16,16a-decahydro-8a-hydroxy-2,6a,10b-trimethyl-, (1S,2S,3S,6R,6aS,8aR,10aS,10bR,16aR,17R,18aR)-
CBNumber: CB21363823
Molecular Formula: C28H30O9
Formula Weight: 510.536
MOL File: 23133-56-4.mol

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physalin B Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 12.27±0.70(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: SHG0005817
Product name: PHYSALIN B
Purity: 95.00%
Packaging: 5MG
Price: $505.33
Updated: 2021/12/16

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physalin B Chemical Properties,Usage,Production

Uses

Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro[1][2].

Definition

ChEBI: A physalin with antimalarial, antitumour and antimicrobial activities isolated from Physalis angulata.

References

[1] Wang A, et al. Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Biomed Pharmacother. 2018;101:334-341. DOI:10.1016/j.biopha.2018.02.094
[2] Ma YM, et al. Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. Acta Pharmacol Sin. 2015;36(4):517-527. DOI:10.1038/aps.2014.157

physalin B Preparation Products And Raw materials

Raw materials

Preparation Products

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physalin B Suppliers

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23133-56-4, physalin BRelated Search:

PHYSALIN D 1,17:2,6-Dimethano-8H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,19(1H,8aH)-tetrone, 2,3,6,6a,9,10,10a,10b,14,16,16a,17-dodecahydro-8a,16,17-trihydroxy-2,3,6a,10b-tetramethyl-, (1S,2S,3S,6R,6aS,8aR,10aS,10bR,16R,16aS,17R,18aR)- (13S,14R,22R,25S)-1,15-Dioxo-5-chloro-6β,13,20,22-tetrahydroxy-14,17α:14,27-diepoxy-16β,24-cyclo-13,14-seco-5α-ergosta-2-ene-18,26-dioic acid 18,20:26,22-dilactone (16S,22R)-14α,17α-Epoxy-7α,13,14,20,22-pentahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone Physalin G physalin F (16β,22R)-14α,17-Epoxy-13,14,20,22-tetrahydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5,25(27)-triene-18,26-dioic acid 18,20:26,22-dilactone Ribose cyclobutyrol 3-HEPTYLDIHYDRO-5-METHYL-2(3H)-FURANONE HEXADECANEDIOIC ACID 1,4-DIOXACYCLOHEXADECANE-5,16-DIONE CIS-4-DECENAL DIETHYL ACETAL delta-Tetradecalactone CIS-6-NONEN-1-AL DIMETHYL ACETAL TERT-BUTYL (R)-(+)-2-HYDROXYBUTYRATE DODECANEDIOIC ACID DIETHYL ESTER L-Threonolactone

physalin B

(16S,22R,25S)-14α,17α:14,27-Diepoxy-13,20,22-trihydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5-diene-18,26-dioic acid 18,20:26,22-dilactone

(16S,25S)-14α,17α:14,27-Diepoxy-13,20,22α-trihydroxy-1,15-dioxo-16,24-cyclo-13,14-secoergosta-2,5-diene-18,26-dioic acid 18,20:26,22-dilactone

17,3-(Epoxymethano)-1,17:2,6-dimethano-17H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,21(1H,8aH,10bH)-tetrone, 2,3,6,6a,9,10,10a,14,16,16a-decahydro-8a-hydroxy-2,6a,10b-trimethyl-, (1S,2S,3S,6R,6aS,8aR,10aS,10bR,16aR,17R,18aR)-

NSC-287088

Physalin B, 10 mM in DMSO

23133-56-4

C28H30O9