6-BROMO-QUINAZOLIN-4-YLAMINE

6-BROMO-QUINAZOLIN-4-YLAMINE Property

Melting point:

>350 °C

Boiling point:

385.4±27.0 °C(Predicted)

Density 

1.744±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

7.04±0.50(Predicted)

Appearance

White to light yellow Solid

Safety

Risk Statements 

41

Safety Statements 

26-39

HazardClass 

IRRITANT

HS Code 

2933998090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

6-BROMO-QUINAZOLIN-4-YLAMINE Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 6-bromoquinazolin-4-amine from 6-bromo-2H-benzo[d][1,3]oxazine-2,4(1H)-dione: 6-bromoisoanisic anhydride (2 g, 8.26 mmol) was bubbled with ammonia into a solution of DMF (20 mL) for 15 min at room temperature. Subsequently, degassing was carried out by bubbling nitrogen into the solution for 5 min while removing the generated (NH4)2CO3. The reaction solution was cooled to 0 °C and POCl3 (2 mL) was added dropwise slowly. After the dropwise addition, the reaction mixture was gradually warmed to 50 °C, maintained at this temperature for 30 min, and then cooled to room temperature. Water (6 mL) and 35% ammonium hydroxide solution (9 mL) were added to the cooled reaction mixture. The resulting mixture was heated at 100 °C for 1 hour and subsequently cooled to room temperature. During this process, a white precipitate was generated. The solid was collected by filtration to afford the white solid product 6-bromoquinazolin-4-amine (1.51 g, 82% yield). The product was confirmed by mass spectrometry (ES+) with m/e 224 [M+H]+ and molecular formula C8H6BrN3.

References

[1] Patent: WO2007/38331, 2007, A2. Location in patent: Page/Page column 39-40