Methyl 5-methoxy-2-nitrobenzoate
- Product Name
- Methyl 5-methoxy-2-nitrobenzoate
- CAS No.
- 2327-45-9
- Chemical Name
- Methyl 5-methoxy-2-nitrobenzoate
- Synonyms
- 5-Methoxy-2-nitroMethylbenzoate;METHYL 5-METHOXY-2-NITROBENZOATE;Methyl5-methoxy-2-nitrobenzoate98%;Methyl 5-methoxy-2-nitrobenzoate 98%;5-Methoxy-2-nitro-benzoic acid methyl ester;Benzoic acid,5-Methoxy-2-nitro-, Methyl ester
- CBNumber
- CB2142605
- Molecular Formula
- C9H9NO5
- Formula Weight
- 211.17
- MOL File
- 2327-45-9.mol
Methyl 5-methoxy-2-nitrobenzoate Property
- Melting point:
- 58-59 °C
- Boiling point:
- 196-198 °C(Press: 15-16 Torr)
- Density
- 1.294±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystals
- color
- Light lemon/yellow, granular
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M338748
- Product name
- Methyl5-Methoxy-2-nitrobenzoate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR7411
- Product name
- Methyl5-methoxy-2-nitrobenzoate
- Purity
- 98%
- Packaging
- 5g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- 4654-1-77
- Product name
- Methyl 5-methoxy-2-nitrobenzoate
- Packaging
- 5G
- Price
- $108
- Updated
- 2021/12/16
- Product number
- OR7411
- Product name
- Methyl5-methoxy-2-nitrobenzoate
- Purity
- 98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 4654-1-77
- Product name
- Methyl 5-methoxy-2-nitrobenzoate
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
Methyl 5-methoxy-2-nitrobenzoate Chemical Properties,Usage,Production
Description
Methyl 5-methoxy-2-nitrobenzoate is an important organic intermediate, commonly used in organic synthesis. This compound can be synthesized from 5-Hydroxy-2-nitrobenzoic acid.
Synthesis
67-56-1
1882-69-5
2327-45-9
To a pressure-resistant reaction flask was added 5-methoxy-2-nitrobenzoic acid (3.98 g, 20.0 mmol) and anhydrous methanol (10 mL). Concentrated sulfuric acid (150 μL) was added slowly and dropwise. The reaction vial was sealed and the reaction was stirred at 85 °C for 4 days. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to half the original volume. Ethyl acetate (25 mL) was added to dilute, and the organic phase was washed sequentially with water (25 mL), saturated aqueous sodium bicarbonate solution (2 × 25 mL), saturated saline (2 × 25 mL) and water (2 × 25 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl 5-methoxy-2-nitrobenzoate as a yellow oil (3.57 g, 87% yield). Its nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) data were as follows: δ 8.04 (d, J = 8.8 Hz, 1H, H-6), 7.04 (d, J = 2.3 Hz, 1H, H-3), 7.00 (dd, J = 8.8, 2.8 Hz, 1H, H-4), 3.93 (s, 3H, OCH3), 3.91 (s. 3H, OCH3). The nuclear magnetic resonance carbon spectrum (13C NMR, 75 MHz, CDCl3) data were as follows: δ 166.7, 163.5, 140.2, 131.4, 126.8, 115.9, 114.2, 56.4, 53.5. The obtained data are in agreement with the literature reports.
References
[1] Synlett, 2016, vol. 27, # 8, p. 1237 - 1240
[2] Patent: WO2005/121152, 2005, A1. Location in patent: Page/Page column 30
Methyl 5-methoxy-2-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 5-methoxy-2-nitrobenzoate manufacturers
- Product
- METHYL 5-METHOXY-2-NITROBENZOATE 2327-45-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11