ChemicalBook > CAS DataBase List > 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone

1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone

Product Name
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
CAS No.
487-49-0
Chemical Name
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
Synonyms
Ononetin;2,4-Dihydroxyphenyl 4-Methoxybenzyl Ketone;4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;Ethanone,1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)-;2’, 4’-Dihydroxy-2(4-methoxyphenyl) acetophenone (Ononetin);Inhibitor,Transient receptor potential channels,Ononetin,inhibit,Ca2+,TRP Channel,TRPM3,deoxybenzoin
CBNumber
CB21458187
Molecular Formula
C15H14O4
Formula Weight
258.27
MOL File
487-49-0.mol
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1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Property

Melting point:
158.0 to 162.0 °C
Boiling point:
464.7±14.0 °C(Predicted)
Density 
1.275±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
7.65±0.35(Predicted)
color 
White to Light yellow to Dark green
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Safety

RTECS 
KM5775350
HS Code 
2914.50.3000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4816
Product name
2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
Purity
>98.0%(T)
Packaging
1g
Price
$276
Updated
2025/07/31
TCI Chemical
Product number
D4816
Product name
2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
Purity
>98.0%(T)
Packaging
200mg
Price
$80
Updated
2025/07/31
Tocris
Product number
5143
Product name
Ononetin
Purity
≥98%(HPLC)
Packaging
50
Price
$70
Updated
2021/12/16
TRC
Product number
O656508
Product name
Ononetin
Packaging
10mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
256112
Product name
Ononetin
Packaging
50mg
Price
$290
Updated
2021/12/16
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1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Chemical Properties,Usage,Production

Uses

Ononetin is a potent and selective transient receptor potential TRMP3 blocker and may represent a novel concept for analgesic treatment.

Definition

ChEBI: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone is a stilbenoid.

Preparation

Preparation by condensation of p-methoxyphenyl-acetonitrile with resorcinol (Hoesch reaction).

in vivo

Ononetin (10 mg/kg, i.p.) treatment completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms and suggests that TRPM3 may be a tractable target for inflammatory pain[2].

IC 50

TRPM3: 0.3 μM (IC50)

storage

Store at +4°C

1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Suppliers

Americas 1 China 69 Europe 1 India 6 Japan 1 United Kingdom 2 United States 9 USA 1 Global 90
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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InvivoChem
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+1-708-310-1919 +1-13798911105
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487-49-0, 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanoneRelated Search:

Formononetin 4',7-Dimethoxy-5-hydroxyisoflavone Rotenone 4',7-Dimethoxyisoflavone Ononin 4',6,7-Trimethoxyisoflavone 1-(2,4,6-Trihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Biochanin A-beta-D-glucoside 5,7-Dihydrox -4'-methoxyisoflavone 6,7-DIHYDROXY-4'-METHOXYISOFLAVONE 4H-1-Benzopyran-4-one, 3-(3,4-dimethoxyphenyl)-7-methoxy- 7,8-DIHYDROXY-4'-METHOXYISOFLAVONE 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone 2-CARBETHOXY-5,7-DIHYDROXY-4'-METHOXYISOFLAVONE PSEUDOBAPTIGENIN ISO-OSAJIN-4'-METHYL ETHER AKOS 212-61 ICHTHYNONE

  • Ononetin
  • Ethanone,1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)-
  • 2,4-Dihydroxyphenyl 4-Methoxybenzyl Ketone
  • 2’, 4’-Dihydroxy-2(4-methoxyphenyl) acetophenone (Ononetin)
  • 4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
  • Inhibitor,Transient receptor potential channels,Ononetin,inhibit,Ca2+,TRP Channel,TRPM3,deoxybenzoin
  • 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
  • 487-49-0