2-(Pyrimidin-5-yl)benzaldehyde

Product Name: 2-(Pyrimidin-5-yl)benzaldehyde
CAS No.: 640769-71-7
Chemical Name: 2-(Pyrimidin-5-yl)benzaldehyde
Synonyms: AKOS BAR-0660;2-PYRIMIDIN-5-YLBENZALDEHYDE;2-(5-PYRIMIDINYL)BENZALDEHYDE;2-(pyrimidine-5-yl)benzaldehyde;Benzaldehyde, 2-(5-pyrimidinyl)-;2-(Pyrimidin-5-yl)benzaldehyde ISO 9001：2015 REACH
CBNumber: CB2146320
Molecular Formula: C11H8N2O
Formula Weight: 184.19
MOL File: 640769-71-7.mol

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2-(Pyrimidin-5-yl)benzaldehyde Property

Melting point:: 119-120°C
Boiling point:: 375.8±35.0 °C(Predicted)
Density: 1.205±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.63±0.10(Predicted)
form: solid
Appearance: White to off-white Solid
CAS DataBase Reference: 640769-71-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39-39
Hazard Note: Irritant

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 930067
Product name: 2-(Pyrimidin-5-yl)benzaldehyde
Packaging: 1G
Price: $198.55
Updated: 2025/07/31

TRC

Product number: P997385
Product name: 2-(Pyrimidin-5-yl)benzaldehyde
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: W7588
Product name: 2-Pyrimidin-5-yl-benzaldehyde
Packaging: 1g
Price: $83
Updated: 2021/12/16

Matrix Scientific

Product number: 071852
Product name: 2-Pyrimidin-5-yl-benzaldehyde
Purity: 95+%
Packaging: 1g
Price: $139
Updated: 2021/12/16

Matrix Scientific

Product number: 071852
Product name: 2-Pyrimidin-5-yl-benzaldehyde
Purity: 95+%
Packaging: 5g
Price: $500
Updated: 2021/12/16

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2-(Pyrimidin-5-yl)benzaldehyde Chemical Properties,Usage,Production

Uses

2-(Pyrimidin-5-yl)benzaldehyde is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maitiμs lab th at promote site selectivity without the inclusion of additional synthetic steps.

2-(pyrimidin-5-yl)benzaldehyde is an effective TDG for meta directed C-H functionalization of amine substituted target compounds, with high selectivity.

Synthesis

4595-59-9

40138-16-7

640769-71-7

GENERAL STEPS: 2-formylphenylboronic acid (290 mg, 2.0 mmol), 5-bromopyrimidine (316 mg, 2.0 mmol), and acetonitrile (8 mL) were added sequentially to a 20 mL microwave reaction tube. Subsequently, 1 M aqueous sodium carbonate (4 mL) and dichlorobis(triphenylphosphine)palladium(II) (100 mg) were added to the mixture. The reaction tube was sealed and the reaction was carried out by microwave radiation at 150 °C for 5 min. After completion of the reaction, the reaction was cooled to room temperature and the reaction mixture was extracted with ethyl acetate. The organic layers were combined and concentrated under reduced pressure to obtain the crude product. The crude product was purified by ISCO fast chromatography system to obtain the target compound 2-(pyrimidin-5-yl)benzaldehyde (220 mg).

References

[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 18, p. 8607 - 8618
[2] Patent: US2008/153852, 2008, A1. Location in patent: Page/Page column 27
[3] Patent: CN104045626, 2017, B. Location in patent: Paragraph 0318

2-(Pyrimidin-5-yl)benzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Pyrimidin-5-yl)benzaldehyde Suppliers

Canada 1 China 63 Germany 2 India 1 Russia 1 United Kingdom 5 United States 15 Global 88

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View Lastest Price from 2-(Pyrimidin-5-yl)benzaldehyde manufacturers

Dideu Industries Group Limited

Product: 2-(Pyrimidin-5-yl)benzaldehyde 640769-71-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-09

Career Henan Chemical Co

Product: 2-(Pyrimidin-5-yl)benzaldehyde 640769-71-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

640769-71-7, 2-(Pyrimidin-5-yl)benzaldehydeRelated Search:

4-Hydroxybenzaldehyde 2-Pyrimidinecarboxaldehyde 4-Dimethylaminobenzaldehyde 3-(Trifluoromethyl)benzaldehyde 3-Methoxybenzaldehyde 2-Nitrobenzaldehyde Pyrimidine-5-carboxaldehyde p-Anisaldehyde Benzaldehyde 2-(2-AMINOPYRIMIDIN-5-YL)BENZALDEHYDE 1-[2-(5-PYRIMIDINYL)PHENYL]ETHANONE 2-(Pyrimidin-5-yl)benzaldehyde

AKOS BAR-0660

2-(5-PYRIMIDINYL)BENZALDEHYDE

2-PYRIMIDIN-5-YLBENZALDEHYDE

Benzaldehyde, 2-(5-pyrimidinyl)-

2-(Pyrimidin-5-yl)benzaldehyde ISO 9001：2015 REACH

2-(pyrimidine-5-yl)benzaldehyde

640769-71-7

ALDEHYDE

Heterocyclic Compound

Benzaldehyde