2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE

Product Name: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
CAS No.: 38385-95-4
Chemical Name: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
Synonyms: AKOS BBS-00005832;CHEMBRDG-BB 4003376;TIMTEC-BB SBB002504;Bilastine impurity H;OTAVA-BB BB7020410139;Bilasten intermediate 1;2-(4-Piperidinyl)benzimidazole;2-Piperdin-4-yl-1H-Benzimidazole;2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE;2-(4-Piperidyl)-1H-benzoimidazole
CBNumber: CB2146618
Molecular Formula: C12H15N3
Formula Weight: 201.27
MOL File: 38385-95-4.mol

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2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Property

Melting point:: 230 °C (decomp)(Solv: water (7732-18-5))
Boiling point:: 441.3±38.0 °C(Predicted)
Density: 1.167±0.06 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
form: Solid
pka: 11.83±0.10(Predicted)
color: White to Light yellow to Light orange
λmax: 279nm(MeOH)(lit.)
InChI: InChI=1S/C12H15N3/c1-2-4-11-10(3-1)14-12(15-11)9-5-7-13-8-6-9/h1-4,9,13H,5-8H2,(H,14,15)
InChIKey: HBOGHPAOOWUTLB-UHFFFAOYSA-N
SMILES: C1(C2CCNCC2)NC2=CC=CC=C2N=1

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Safety

Hazard Codes: Xi
HS Code: 2933.99.8290
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2382
Product name: 2-(4-Piperidinyl)benzimidazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $117
Updated: 2025/07/31

TCI Chemical

Product number: P2382
Product name: 2-(4-Piperidinyl)benzimidazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $347
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: CHM0074444
Product name: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
Purity: 95.00%
Packaging: 2.5G
Price: $1037.94
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0074444
Product name: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
Purity: 95.00%
Packaging: 5G
Price: $1252.83
Updated: 2021/12/16

AK Scientific

Product number: J50744
Product name: 2-Piperidin-4-yl-1H-benzoimidazole
Packaging: 100g
Price: $690
Updated: 2021/12/16

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2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Chemical Properties,Usage,Production

Chemical Properties

2-(4-piperidinyl)-1H-benzimidazole is white or brownish-yellow solid under normal temperature and pressure, with good solubility in methanol.

Uses

2-Piperidin-4-yl-1H-benzimidazole is used as a reagent in the synthesis of 3-amino-1-(5-indanyloxy)-2-propanol derivatives as potent sodium channel blockers for the treatment of ischemic stroke. Also used as a reagent in the synthesis of 2,3,5-trisubstituted pyridine derivatives as potent Akt1/Akt2 dual inhibitors.

Synthesis

498-94-2

95-54-5

38385-95-4

The general procedure for the synthesis of 2-(4-piperidinyl)-1H-benzimidazole from 4-piperidinecarboxylic acid and o-phenylenediamine was as follows: according to the method described in the literature (J. Heterocyclic Chem., 1989, 26, 54), benzene-1,2-diamine (12.6 g, 116 mmol) was mixed with piperidine-4-carboxylic acid (15 g, 116 mmol) in a 4M HCl aqueous solution (250 mL), stirred and heated under reflux conditions for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to alkaline with 5 M NaOH aqueous solution. The precipitate precipitated was collected by filtration, washed with water and subsequently dried in a vacuum oven to afford the target product 2-(piperidin-4-yl)-1H-benzimidazole 8.8 g in 38% yield. Mass spectrometry analysis showed m/z = 202 [M+ + H].

References

[1] Patent: US6660751, 2003, B1. Location in patent: Page column 7,8
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 3, p. 695 - 699
[3] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 3, p. 707 - 718
[4] Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 541 - 543
[5] Patent: WO2010/80357, 2010, A1. Location in patent: Page/Page column 41-42

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Suppliers

China 212 France 1 Germany 3 Hungary 1 India 40 Japan 1 Russia 2 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 2 United States 23 Global 289

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View Lastest Price from 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 2-(4-Piperidyl)-1H-1,3-benzimidazole 38385-95-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-09-22

Jinan Ruitong Biotech Co., Ltd.

Product: 2-Piperdin-4-yl-1H-Benzimidazole 38385-95-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-27

Anhui Dexinjia Biopharm Co., Ltd

Product: 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE 38385-95-4
Price: US $100.00-2000.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 5MT per month
Release date: 2021-12-14

38385-95-4, 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLERelated Search:

AKOS BBS-00005832

2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE

2-(PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE

2-(4-PIPERIDYL)-1H-1,3-BENZIMIDAZOLE

OTAVA-BB BB7020410139

TIMTEC-BB SBB002504

2-(4-piperidinyl)-1H-benzimidazole

CHEMBRDG-BB 4003376

2-piperidin-4-yl-1H-benzimidazole(SALTDATA: 2HCl 0.5H2O)

1H-BenziMidazole,2-(4-piperidinyl)-

2-(4-Piperidyl)-1H-benzoimidazole

Bilasten intermediate 1

Bilastine impurity H

2-(4-Piperidinyl)benzimidazole

2-Piperdin-4-yl-1H-Benzimidazole

2-(4-piperidine) -1H-benzimidazole

2-Piperdin-4-yl-1H-benziomidazole

1-(4- Piperidinyl ) benzimidazole

2-Piperdin-4-yl-1H-benziomimidazole

Hydrocortisone Acetate Impurity 1 (Hydrocortisone Acetate EP Impurity A)

38385-95-4