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2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE

Product Name
2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
CAS No.
38385-95-4
Chemical Name
2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
Synonyms
AKOS BBS-00005832;CHEMBRDG-BB 4003376;TIMTEC-BB SBB002504;Bilastine impurity H;OTAVA-BB BB7020410139;Bilasten intermediate 1;2-(4-Piperidinyl)benzimidazole;2-Piperdin-4-yl-1H-Benzimidazole;2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE;2-(4-Piperidyl)-1H-benzoimidazole
CBNumber
CB2146618
Molecular Formula
C12H15N3
Formula Weight
201.27
MOL File
38385-95-4.mol
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2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Property

Melting point:
230 °C (decomp)(Solv: water (7732-18-5))
Boiling point:
441.3±38.0 °C(Predicted)
Density 
1.167±0.06 g/cm3(Predicted)
vapor pressure 
0Pa at 25℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
form 
Solid
pka
11.83±0.10(Predicted)
color 
White to Light yellow to Light orange
λmax
279nm(MeOH)(lit.)
InChI
InChI=1S/C12H15N3/c1-2-4-11-10(3-1)14-12(15-11)9-5-7-13-8-6-9/h1-4,9,13H,5-8H2,(H,14,15)
InChIKey
HBOGHPAOOWUTLB-UHFFFAOYSA-N
SMILES
C1(C2CCNCC2)NC2=CC=CC=C2N=1
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Safety

Hazard Codes 
Xi
HS Code 
2933.99.8290
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2382
Product name
2-(4-Piperidinyl)benzimidazole
Purity
>98.0%(GC)
Packaging
1g
Price
$117
Updated
2025/07/31
TCI Chemical
Product number
P2382
Product name
2-(4-Piperidinyl)benzimidazole
Purity
>98.0%(GC)
Packaging
5g
Price
$347
Updated
2025/07/31
AK Scientific
Product number
J50744
Product name
2-Piperidin-4-yl-1H-benzoimidazole
Packaging
1g
Price
$15
Updated
2021/12/16
AK Scientific
Product number
W5915
Product name
2-Piperidin-4-yl-1H-benzoimidazole
Packaging
5g
Price
$54
Updated
2021/12/16
Matrix Scientific
Product number
010422
Product name
2-Piperidin-4-yl-1H-benzoimidazole
Packaging
1g
Price
$61
Updated
2021/12/16
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2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Chemical Properties,Usage,Production

Chemical Properties

2-(4-piperidinyl)-1H-benzimidazole is white or brownish-yellow solid under normal temperature and pressure, with good solubility in methanol.

Uses

2-Piperidin-4-yl-1H-benzimidazole is used as a reagent in the synthesis of 3-amino-1-(5-indanyloxy)-2-propanol derivatives as potent sodium channel blockers for the treatment of ischemic stroke. Also used as a reagent in the synthesis of 2,3,5-trisubstituted pyridine derivatives as potent Akt1/Akt2 dual inhibitors.

Synthesis

498-94-2

95-54-5

38385-95-4

The general procedure for the synthesis of 2-(4-piperidinyl)-1H-benzimidazole from 4-piperidinecarboxylic acid and o-phenylenediamine was as follows: according to the method described in the literature (J. Heterocyclic Chem., 1989, 26, 54), benzene-1,2-diamine (12.6 g, 116 mmol) was mixed with piperidine-4-carboxylic acid (15 g, 116 mmol) in a 4M HCl aqueous solution (250 mL), stirred and heated under reflux conditions for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to alkaline with 5 M NaOH aqueous solution. The precipitate precipitated was collected by filtration, washed with water and subsequently dried in a vacuum oven to afford the target product 2-(piperidin-4-yl)-1H-benzimidazole 8.8 g in 38% yield. Mass spectrometry analysis showed m/z = 202 [M+ + H].

References

[1] Patent: US6660751, 2003, B1. Location in patent: Page column 7,8
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 3, p. 695 - 699
[3] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 3, p. 707 - 718
[4] Journal of Heterocyclic Chemistry, 1989, vol. 26, p. 541 - 543
[5] Patent: WO2010/80357, 2010, A1. Location in patent: Page/Page column 41-42

2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE Suppliers

China 211 France 1 Germany 3 Hungary 1 India 40 Japan 1 Russia 2 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 2 United States 23 Global 288
Enamine
Tel
--
Fax
--
Email
enamine@enamine.net
Country
Ukraine
ProdList
6216
Advantage
67
OTAVA chemicals
Tel
--
Fax
--
Email
north.america@otavachemicals.com
Country
Ukraine
ProdList
6495
Advantage
72
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View Lastest Price from 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
2-(4-Piperidyl)-1H-1,3-benzimidazole 38385-95-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2025-09-22
Jinan Ruitong Biotech Co., Ltd.
Product
2-Piperdin-4-yl-1H-Benzimidazole 38385-95-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-27
Anhui Dexinjia Biopharm Co., Ltd
Product
2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE 38385-95-4
Price
US $100.00-2000.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
5MT per month
Release date
2021-12-14

38385-95-4, 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLERelated Search:

2-PIPERIDIN-3-YL-1H-BENZOIMIDAZOLE 1-METHYL-2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE 6-BROMO-2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE alinastine 5-FLUORO-2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE,5-Fuoro-2-piperidin-4-yl-1H-benzoimidazole 6-METHYL-2-(PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE 5-METHYL-2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE 5-FLUORO-2-PIPERIDIN-2-YL-1H-BENZOIMIDAZOLE 5-Methoxy-2-piperidin-3-yl-1H-benzoimidazole hydrochloride 2-PIPERIDIN-2-YL-1H-BENZOIMIDAZOLE 5-Fluoro-2-piperidin-4-yl-1H-benzoimidazole HYDROCHLORIDE 5-FLUORO-2-PIPERIDIN-3-YL-1H-BENZOIMIDAZOLE 2-Piperidin-4-yl-1H-benzoimidazole hydrochloride 5-Methoxy-2-piperidin-4-yl-1H-benzoimidazole hydrochloride 5-Methoxy-2-piperidin-2-yl-1H-benzoimidazole hydrochloride 5-Fluoro-2-piperidin-3-yl-1H-benzoimidazole hydrochloride 2-Piperidin-2-yl-1H-benzoimidazole hydrochloride

  • AKOS BBS-00005832
  • 2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE
  • 2-(PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE
  • 2-PIPERIDIN-4-YL-1H-BENZOIMIDAZOLE
  • 2-(4-PIPERIDYL)-1H-1,3-BENZIMIDAZOLE
  • OTAVA-BB BB7020410139
  • TIMTEC-BB SBB002504
  • 2-(4-piperidinyl)-1H-benzimidazole
  • CHEMBRDG-BB 4003376
  • 2-piperidin-4-yl-1H-benzimidazole(SALTDATA: 2HCl 0.5H2O)
  • 1H-BenziMidazole,2-(4-piperidinyl)-
  • 2-(4-Piperidyl)-1H-benzoimidazole
  • Bilasten intermediate 1
  • Bilastine impurity H
  • 2-(4-Piperidinyl)benzimidazole
  • 2-Piperdin-4-yl-1H-Benzimidazole
  • 2-(4-piperidine) -1H-benzimidazole
  • 2-Piperdin-4-yl-1H-benziomidazole
  • 1-(4- Piperidinyl ) benzimidazole
  • 2-Piperdin-4-yl-1H-benziomimidazole
  • Hydrocortisone Acetate Impurity 1 (Hydrocortisone Acetate EP Impurity A)
  • 38385-95-4