3-Bromo-2-hydroxy-5-iodopyridine

Product Name: 3-Bromo-2-hydroxy-5-iodopyridine
CAS No.: 637348-81-3
Chemical Name: 3-Bromo-2-hydroxy-5-iodopyridine
Synonyms: 3-Bromo-5-iodopyridin-2-o;3-broMo-5-iodopyridin-2-ol;3-bromo-5-iodopyridin-2(1H)-one;3-Bromo-5-iodo-1H-pyridin-2-one;3-bromo-5-iodo-2(1H)-Pyridinone;3-BroMo-5-iodo-2-hydroxypyridine;3-Bromo-2-hydroxy-5-iodopyridine;2(1H)-Pyridinone, 3-bromo-5-iodo-
CBNumber: CB21471184
Molecular Formula: C5H3BrINO
Formula Weight: 299.89
MOL File: 637348-81-3.mol

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3-Bromo-2-hydroxy-5-iodopyridine Property

Boiling point:: 308.0±42.0 °C(Predicted)
Density: 2.55±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 8.66±0.10(Predicted)
Appearance: Off-white to gray Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 9745AB
Product name: 3-Bromo-5-iodopyridin-2-ol
Packaging: 250mg
Price: $188
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-S-14
Product name: 3-Bromo-2-hydroxy-5-iodopyridine
Purity: 95.0%
Packaging: 1g
Price: $343
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0361076
Product name: 3-BROMO-2-HYDROXY-5-IODOPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $502.44
Updated: 2021/12/16

AK Scientific

Product number: 9745AB
Product name: 3-Bromo-5-iodopyridin-2-ol
Packaging: 5g
Price: $805
Updated: 2021/12/16

Matrix Scientific

Product number: 161803
Product name: 3-Bromo-5-iodopyridin-2-ol
Purity: 95%
Packaging: 5g
Price: $1486
Updated: 2021/12/16

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3-Bromo-2-hydroxy-5-iodopyridine Chemical Properties,Usage,Production

Synthesis

13466-43-8

637348-81-3

The general procedure for the synthesis of 3-bromo-2-hydroxy-5-iodopyridine from 3-bromo-2-hydroxypyridine is as follows: Example 142a Synthesis of 3-bromo-5-iodopyridin-2-ol In a 100 mL single-necked round-bottomed flask equipped with a magnetic stirrer, acetonitrile (50 mL), trifluoroacetic acid (TFA, 10 mL), 3-bromo-2-hydroxypyridine (4.0 g, 23.12 mmol), and N-iodosuccinimide (NIS, 5.2 g, 23.12 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 15 hours. Upon completion of the reaction, the mixture was diluted with 100 mL of water and the resulting white solid was collected by filtration to afford the target product 3-bromo-5-iodopyridin-2-ol (142a, 6.6 g, 96% yield). Mass spectrometry analysis (MS-ESI): [M + H]+ m/z 300.

References

[1] Patent: US2013/116246, 2013, A1. Location in patent: Paragraph 0467
[2] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0844; 0845
[3] Synlett, 2003, # 11, p. 1678 - 1682
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 9, p. 2157 - 2165
[5] Patent: WO2007/126733, 2007, A2. Location in patent: Page/Page column 33; 46-47

3-Bromo-2-hydroxy-5-iodopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-2-hydroxy-5-iodopyridine Suppliers

China 60 Germany 1 India 2 United States 4 Global 67

PharmaBlock Sciences (Nanjing),Inc.

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637348-81-3, 3-Bromo-2-hydroxy-5-iodopyridineRelated Search:

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3-Bromo-2-hydroxy-5-iodopyridine

3-broMo-5-iodopyridin-2-ol

3-BroMo-5-iodo-2-hydroxypyridine

3-bromo-5-iodo-2(1H)-Pyridinone

3-Bromo-5-iodo-1H-pyridin-2-one

2(1H)-Pyridinone, 3-bromo-5-iodo-

3-bromo-5-iodopyridin-2(1H)-one

3-Bromo-5-iodopyridin-2-o

637348-81-3