6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

Product Name: 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
CAS No.: 147497-32-3
Chemical Name: 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
Synonyms: 6-bromo-3,4-dihydroisoquinolin-1(2H)-one;6-broMo-1,2,3,4-tetrahydroisoquinolin-1-one;6-BROMO-3,4-1(1H)-ISOQUINOLINONE;6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ON;6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;6-BROMO-3,4-DIHYDRO-1(1H)-ISOQUINOLINONE;6-Bromo-3,4-dihydro-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 6-bromo-3,4-dihydro-;6-BroMo-1-oxo-1,2,3,4-tetrahydroisoquinoline;1(2H)-Isoquinolinone, 6-bromo-3,4-dihydro- , 97%min
CBNumber: CB2147125
Molecular Formula: C9H8BrNO
Formula Weight: 226.07
MOL File: 147497-32-3.mol

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6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Property

Melting point:: 170.0-173.1 °C
Boiling point:: 453.3±45.0 °C(Predicted)
Density: 1.559±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder
pka: 14.22±0.20(Predicted)
color: Yellow

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B683520
Product name: 6-Bromo-3,4-dihydro-2H-isoquinolin-1-one
Packaging: 1g
Price: $195
Updated: 2021/12/16

Ark Pharm

Product number: P000213853
Product name: 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one
Purity: 98%
Packaging: 250mg
Price: $26
Updated: 2021/12/16

Ark Pharm

Product number: P000213853
Product name: 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one
Purity: 98%
Packaging: 1g
Price: $52
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19108
Product name: 6-Bromo-3,4-dihydro-2H-isoquinolin-1-one
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19108
Product name: 6-Bromo-3,4-dihydro-2H-isoquinolin-1-one
Packaging: 500mg
Price: $100
Updated: 2021/12/16

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6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Chemical Properties,Usage,Production

Uses

6-bromo-3,4-dihydroisoquinolin-1(2H)-one is an intermediate used in the synthesis of benzolactams as dopamine D3 receptor ligands.IT is also used in the synthesis of new, selective 3-aminopyrazole based MK2-inhibitors that was proved to inhibit intracellular phosphorylation of hsp27 as well as LPS-induced TNFα release in cells.

Synthesis

34598-49-7

147497-32-3

1. 5-bromo-1-indanone (8a) (1.08 g, 5.1 mmol) was weighed into a 100 mL round bottom flask. 2. dichloromethane (30 mL), methanesulfonic acid (15 mL) and sodium azide (0.5 g, 7.7 mmol) were added sequentially to the reaction flask at 0°C. The reaction was carried out at room temperature. 3. The reaction mixture was stirred at room temperature for 3 hours. 4. Upon completion of the reaction, 1.0 M aqueous sodium hydroxide (50 mL) was slowly added to the reaction solution to quench the reaction. 5. The aqueous phase was extracted with dichloromethane (100 mL x 1) and the organic phases were combined. 6. The organic phase was washed with saturated brine (40 mL×1), dried over anhydrous sodium sulfate and filtered. 7. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, v/v=3:1) to afford 6-bromo-3,4-dihydro-2H-isoquinolin-1-one (8b) as a gray solid (0.45 g, 39% yield).

References

[1] Patent: US2010/4231, 2010, A1. Location in patent: Page/Page column 67-68
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 9, p. 2670 - 2674
[3] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 0852; 0853; 0854
[4] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0088
[5] Patent: CN107879975, 2018, A. Location in patent: Paragraph 0132; 0134

6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials

Raw materials

Sodium sulfate Sodium chloride Triethylamine Ethyl chloroformate Polyphosphoric acid Tetrahydrofuran Diethyl ether Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Sodium bicarbonate Dichloromethane Methanol Sodium hydroxide Magnesium sulfate Sulfuric acid 3-Bromophenylacetonitrile

Preparation Products

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6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Suppliers

Canada 1 China 136 India 2 United Kingdom 2 United States 18 Global 159

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View Lastest Price from 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE manufacturers

Honest Joy Holdings Limited

Product: 6-Bromo-3,4-dihydro-2h-isoquinolin-1-one 147497-32-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.6%
Supply Ability: 100 tons
Release date: 2022-02-08

147497-32-3, 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONERelated Search:

Hydrogen bromide Citalopram hydrobromide tablets Dextromethorphan hydrobromide monohydrate DiethylaMine hydrobroMide 3,4-Dihydro-2H-isoquinolin-1-one 7-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 6-bromo-1,2,3,4-tetrahydroisoquinoline 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

6-broMo-1,2,3,4-tetrahydroisoquinolin-1-one

6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE

6-bromo-3,4-dihydroisoquinolin-1(2H)-one

6-BROMO-3,4-1(1H)-ISOQUINOLINONE

6-BROMO-3,4-DIHYDRO-1(1H)-ISOQUINOLINONE

6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ON

1(2H)-Isoquinolinone, 6-bromo-3,4-dihydro-

6-Bromo-3,4-dihydro-1(2H)-isoquinolinone

6-BroMo-1-oxo-1,2,3,4-tetrahydroisoquinoline

1(2H)-Isoquinolinone, 6-bromo-3,4-dihydro- , 97%min

147497-32-3

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