D-LYSINE METHYL ESTER DIHYDROCHLORIDE
- Product Name
- D-LYSINE METHYL ESTER DIHYDROCHLORIDE
- CAS No.
- 67396-08-1
- Chemical Name
- D-LYSINE METHYL ESTER DIHYDROCHLORIDE
- Synonyms
- D-Lys-OMe 2HCl;(R)-Methyl 2,6-diaminohexanoate;D-LysineMethylEsterDihydrochloride>METHYL 2,6-DIAMINOHEXANOATE DIHYDROCHLORIDE;D-LYSINE METHYL ESTER DIHYDROCHLORIDE USP/EP/BP;(R)-Methyl 2,6-diaminohexanoate dihydrochloride;methyl (2R)-2,6-diaminohexanoate dihydrochloride;D-Lysine Methyl Ester Dihydrochloride
- CBNumber
- CB21475511
- Molecular Formula
- C7H16N2O2.2HCl
- Formula Weight
- 0
- MOL File
- 67396-08-1.mol
D-LYSINE METHYL ESTER DIHYDROCHLORIDE Property
- Melting point:
- 205 °C
- refractive index
- -17 ° (C=5, H2O)
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Soluble in water
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- powder to crystal
- color
- White to Almost white
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 67396-08-1
Safety
- HS Code
- 2922.41.0090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L0201
- Product name
- D-Lysine Methyl Ester Dihydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 5g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- L0201
- Product name
- D-Lysine Methyl Ester Dihydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 25g
- Price
- $305
- Updated
- 2025/07/31
- Product number
- L468920
- Product name
- D-Lysine Methyl Ester Dihydrochloride
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- L468920
- Product name
- D-Lysine Methyl Ester Dihydrochloride
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 095091
- Product name
- (R)-Methyl 2,6-diaminohexanoate dihydrochloride
- Purity
- 95+%
- Packaging
- 5g
- Price
- $152
- Updated
- 2021/12/16
D-LYSINE METHYL ESTER DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
D-Lysine Methyl Ester is a protected form of D-Lysine (L468930). D-Lysine is the unnatural isomer of L-Lysine (L468895) that has the ability to reduce non-enzymatic glycation in vitro. D-Lysine also exists as polypeptide chains of poly-D-lysine, a nonspecific adhesion-promoting molecule that has the potential to be a polymeric drug carrier.
Synthesis
67-56-1
657-27-2
13515-95-2
L-lysine hydrochloride (2, 5.00 g, 27.4 mmol, 1.0 eq.) and methanol (30 mL, 0.9 M) were added to a round bottom flask. The suspension was heated to reflux to completely dissolve the solid. Thionyl chloride (2.59 mL, 35.6 mmol, 1.3 eq.) was added slowly and dropwise over 15 min. The reaction mixture was kept under reflux conditions for 17 hours. Removal of most of the volatiles (~25 mL) by distillation followed by azeotropic removal of the remaining volatiles by toluene under reduced pressure afforded pure lysine methyl ester dihydrochloride (3, quantitative mass recovery, white solid), which was used directly in the next step of the reaction without further purification. The product was analyzed and the data were consistent with those reported in the literature.
References
[1] Tetrahedron Letters, 2016, vol. 57, # 4, p. 502 - 504
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 17, p. 3669 - 3683
[3] Heterocycles, 2017, vol. 94, # 5, p. 964 - 978
[4] Journal of Polymer Science, Part A: Polymer Chemistry, 2015, vol. 53, # 17, p. 2036 - 2049
[5] Molecules, 2016, vol. 21, # 1,
D-LYSINE METHYL ESTER DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
D-LYSINE METHYL ESTER DIHYDROCHLORIDE Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from D-LYSINE METHYL ESTER DIHYDROCHLORIDE manufacturers
- Product
- D-Lysine Methyl Ester Dihydrochloride 67396-08-1
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-07
- Product
- D-Lys-Ome.2Hcl 67396-08-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-24
- Product
- D-LYSINE METHYL ESTER DIHYDROCHLORIDE 67396-08-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-10