3,3-DIMETHYLPIPERAZIN-2-ONE

Product Name: 3,3-DIMETHYLPIPERAZIN-2-ONE
CAS No.: 22476-74-0
Chemical Name: 3,3-DIMETHYLPIPERAZIN-2-ONE
Synonyms: 3,3-Dimethylpiperazin-2-on;3,3-Dimethyl-2-piperazinone;2-Piperazinone, 3,3-dimethyl-;3,3-dimethylpiperazin-2-one(SALTDATA: FREE)
CBNumber: CB21476598
Molecular Formula: C6H12N2O
Formula Weight: 128.17
MOL File: 22476-74-0.mol

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3,3-DIMETHYLPIPERAZIN-2-ONE Property

Melting point:: 134 °C
Boiling point:: 275.0±33.0 °C(Predicted)
Density: 0.960±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 15.55±0.40(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C6H12N2O/c1-6(2)5(9)7-3-4-8-6/h8H,3-4H2,1-2H3,(H,7,9)
InChIKey: ZBFIRYWCOIYJDA-UHFFFAOYSA-N
SMILES: N1CCNC(C)(C)C1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: D447625
Product name: 3,3-Dimethylpiperazin-2-one
Packaging: 50mg
Price: $60
Updated: 2021/12/16

TRC

Product number: D447625
Product name: 3,3-Dimethylpiperazin-2-one
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 033652
Product name: 3,3-Dimethyl-piperazin-2-one
Packaging: 500mg
Price: $59
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD118115
Product name: 3,3-Dimethylpiperazin-2-one
Packaging: 100mg
Price: $72
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-AJ
Product name: 3,3-Dimethylpiperazin-2-one
Packaging: 250mg
Price: $75
Updated: 2021/12/16

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3,3-DIMETHYLPIPERAZIN-2-ONE Chemical Properties,Usage,Production

Synthesis

600-00-0

107-15-3

22476-74-0

To a solution of ethylenediamine (7.70 g, 128 mmol) in toluene (55 mL) was added slowly and dropwise a solution of ethyl 2-bromo-2-methylpropionate (5.00 g, 25.6 mmol) in toluene (5 mL). The reaction mixture was stirred at room temperature for 1 hour and then warmed up to reflux and continued stirring for 16 hours. Upon completion of the reaction, the mixture was extracted with toluene (30 mL). The organic layer was separated and dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (100-200 mesh, eluent DCM solution containing 2% to 10% ammonia in methanol) to afford 3,3-dimethylpiperazin-2-one (2.81 g, 87% yield) as an off-white solid.LC/MS (ESI) analysis: m/e [M+H]+ 128.90, retention time 0.61 min, purity 69.8%. 1H NMR (400 MHz, DMSO-d6) δ 1.15 (s, 6H), 2.24 (s, 1H), 2.80-2.86 (m, 2H), 3.10-3.16 (m, 2H), 7.35 (s, 1H).

References

[1] Patent: WO2017/20010, 2017, A1. Location in patent: Paragraph 0128
[2] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 113
[3] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9545 - 9548
[4] Patent: WO2005/16900, 2005, A1. Location in patent: Page/Page column 27
[5] Patent: WO2006/86986, 2006, A1. Location in patent: Page/Page column 14-15

3,3-DIMETHYLPIPERAZIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,3-DIMETHYLPIPERAZIN-2-ONE Suppliers

China 83 India 1 Japan 1 Switzerland 1 United Kingdom 1 United States 8 Global 95

Gansu Songsheng Pharmaceutical Co. , Ltd.

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View Lastest Price from 3,3-DIMETHYLPIPERAZIN-2-ONE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 3,3-dimethylpiperazin-2-one 22476-74-0
Price: US $8.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 3,3-Dimethylpiperazin-2-on 22476-74-0
Price: US $8.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-11-26

Career Henan Chemical Co

Product: 3,3-DIMETHYLPIPERAZIN-2-ONE 22476-74-0
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

22476-74-0, 3,3-DIMETHYLPIPERAZIN-2-ONERelated Search:

(2,2-DIMETHYL-3-OXO-PIPERAZIN-1-YL)-ACETIC ACID 3,3-DIMETHYLPIPERAZIN-2-ONE paraherquamide 4-(2,2-DIMETHYL-3-OXO-PIPERAZIN-1-YL)-4-OXO-BUTYRIC ACID 5-(2,2-DIMETHYL-3-OXO-PIPERAZIN-1-YL)-5-OXO-PENTANOIC ACID 4,7-DIAZA-SPIRO[2.5]OCTAN-8-ONE 6,9-Diazaspiro[4.5]decan-10-one(7CI,8CI) 2-(2,2-DIMETHYL-3-OXO-PIPERAZIN-1-YL)-PROPIONIC ACID 6,9-Diazaspiro[4.5]decane-7,10-dione,8-methyl-(9CI) Iminophenimide 1,4-DIAZASPIRO[5.5]UNDECANE-3,5-DIONE 5,8-DIAZA-SPIRO[3.5]NONAN-9-ONE 4-(2,2-DIMETHYL-3-OXO-OCTAHYDRO-QUINOXALIN-1-YL)-4-OXO-BUTYRIC ACID 3,3-DIETHYL-PIPERAZIN-2-ONE 4-(2-CHLORO-ACETYL)-3,3-DIMETHYL-PIPERAZIN-2-ONE 4-(2-CHLORO-ACETYL)-3,3-DIMETHYL-OCTAHYDRO-QUINOXALIN-2-ONE 1,4-DIAZA-SPIRO[5.5]UNDECAN-5-ONE 1,4-DIHYDROXY-3,3,6,6-TETRAMETHYLPIPERAZINE-2,5-DIONE

3,3-dimethylpiperazin-2-one(SALTDATA: FREE)

3,3-Dimethyl-2-piperazinone

2-Piperazinone, 3,3-dimethyl-

3,3-Dimethylpiperazin-2-on

22476-74-0

pharmacetical