ChemicalBook > CAS DataBase List > 3,3-DIMETHYLPIPERAZIN-2-ONE

3,3-DIMETHYLPIPERAZIN-2-ONE

Product Name
3,3-DIMETHYLPIPERAZIN-2-ONE
CAS No.
22476-74-0
Chemical Name
3,3-DIMETHYLPIPERAZIN-2-ONE
Synonyms
3,3-Dimethylpiperazin-2-on;3,3-Dimethyl-2-piperazinone;2-Piperazinone, 3,3-dimethyl-;3,3-dimethylpiperazin-2-one(SALTDATA: FREE)
CBNumber
CB21476598
Molecular Formula
C6H12N2O
Formula Weight
128.17
MOL File
22476-74-0.mol
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3,3-DIMETHYLPIPERAZIN-2-ONE Property

Melting point:
134 °C
Boiling point:
275.0±33.0 °C(Predicted)
Density 
0.960±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
15.55±0.40(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C6H12N2O/c1-6(2)5(9)7-3-4-8-6/h8H,3-4H2,1-2H3,(H,7,9)
InChIKey
ZBFIRYWCOIYJDA-UHFFFAOYSA-N
SMILES
N1CCNC(C)(C)C1=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
D447625
Product name
3,3-Dimethylpiperazin-2-one
Packaging
50mg
Price
$60
Updated
2021/12/16
TRC
Product number
D447625
Product name
3,3-Dimethylpiperazin-2-one
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-1-AJ
Product name
3,3-Dimethylpiperazin-2-one
Packaging
250mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
W4622
Product name
3,3-Dimethylpiperazin-2-one
Packaging
1g
Price
$97
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD118115
Product name
3,3-Dimethylpiperazin-2-one
Packaging
100mg
Price
$72
Updated
2021/12/16
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3,3-DIMETHYLPIPERAZIN-2-ONE Chemical Properties,Usage,Production

Synthesis

600-00-0

107-15-3

22476-74-0

To a solution of ethylenediamine (7.70 g, 128 mmol) in toluene (55 mL) was added slowly and dropwise a solution of ethyl 2-bromo-2-methylpropionate (5.00 g, 25.6 mmol) in toluene (5 mL). The reaction mixture was stirred at room temperature for 1 hour and then warmed up to reflux and continued stirring for 16 hours. Upon completion of the reaction, the mixture was extracted with toluene (30 mL). The organic layer was separated and dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (100-200 mesh, eluent DCM solution containing 2% to 10% ammonia in methanol) to afford 3,3-dimethylpiperazin-2-one (2.81 g, 87% yield) as an off-white solid.LC/MS (ESI) analysis: m/e [M+H]+ 128.90, retention time 0.61 min, purity 69.8%. 1H NMR (400 MHz, DMSO-d6) δ 1.15 (s, 6H), 2.24 (s, 1H), 2.80-2.86 (m, 2H), 3.10-3.16 (m, 2H), 7.35 (s, 1H).

References

[1] Patent: WO2017/20010, 2017, A1. Location in patent: Paragraph 0128
[2] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 113
[3] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9545 - 9548
[4] Patent: WO2005/16900, 2005, A1. Location in patent: Page/Page column 27
[5] Patent: WO2006/86986, 2006, A1. Location in patent: Page/Page column 14-15

3,3-DIMETHYLPIPERAZIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,3-DIMETHYLPIPERAZIN-2-ONE Suppliers

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View Lastest Price from 3,3-DIMETHYLPIPERAZIN-2-ONE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
3,3-dimethylpiperazin-2-one 22476-74-0
Price
US $8.90/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
3,3-Dimethylpiperazin-2-on 22476-74-0
Price
US $8.90/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-11-26
Career Henan Chemical Co
Product
3,3-DIMETHYLPIPERAZIN-2-ONE 22476-74-0
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-05

22476-74-0, 3,3-DIMETHYLPIPERAZIN-2-ONERelated Search:

(2,2-DIMETHYL-3-OXO-PIPERAZIN-1-YL)-ACETIC ACID 3,3-DIMETHYLPIPERAZIN-2-ONE paraherquamide 4-(2,2-DIMETHYL-3-OXO-PIPERAZIN-1-YL)-4-OXO-BUTYRIC ACID 5-(2,2-DIMETHYL-3-OXO-PIPERAZIN-1-YL)-5-OXO-PENTANOIC ACID 4,7-DIAZA-SPIRO[2.5]OCTAN-8-ONE 6,9-Diazaspiro[4.5]decan-10-one(7CI,8CI) 2-(2,2-DIMETHYL-3-OXO-PIPERAZIN-1-YL)-PROPIONIC ACID 6,9-Diazaspiro[4.5]decane-7,10-dione,8-methyl-(9CI) Iminophenimide 1,4-DIAZASPIRO[5.5]UNDECANE-3,5-DIONE 5,8-DIAZA-SPIRO[3.5]NONAN-9-ONE 4-(2,2-DIMETHYL-3-OXO-OCTAHYDRO-QUINOXALIN-1-YL)-4-OXO-BUTYRIC ACID 3,3-DIETHYL-PIPERAZIN-2-ONE 4-(2-CHLORO-ACETYL)-3,3-DIMETHYL-PIPERAZIN-2-ONE 4-(2-CHLORO-ACETYL)-3,3-DIMETHYL-OCTAHYDRO-QUINOXALIN-2-ONE 1,4-DIAZA-SPIRO[5.5]UNDECAN-5-ONE 1,4-DIHYDROXY-3,3,6,6-TETRAMETHYLPIPERAZINE-2,5-DIONE

  • 3,3-dimethylpiperazin-2-one(SALTDATA: FREE)
  • 3,3-Dimethyl-2-piperazinone
  • 2-Piperazinone, 3,3-dimethyl-
  • 3,3-Dimethylpiperazin-2-on
  • 22476-74-0
  • pharmacetical