2,6-Dichloronicotinic acid ethyl ester
- Product Name
- 2,6-Dichloronicotinic acid ethyl ester
- CAS No.
- 58584-86-4
- Chemical Name
- 2,6-Dichloronicotinic acid ethyl ester
- Synonyms
- ethyl 2,6-dichloronicotinate;2,6-Dichloronicotinic acid ethyl ester;Ethyl 2,6-dichloropyridine-3-carboxylate;2,6-Dichloropyridin-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester;2,6-dichloro-3-Pyridinecarboxylic acid ethyl ester (9CI ACI);3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester (9CI, ACI)
- CBNumber
- CB21501258
- Molecular Formula
- C8H7Cl2NO2
- Formula Weight
- 220.05
- MOL File
- 58584-86-4.mol
2,6-Dichloronicotinic acid ethyl ester Property
- Melting point:
- 50.0 to 54.0 °C
- Boiling point:
- 286.0±35.0 °C(Predicted)
- Density
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -4.48±0.10(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C8H7Cl2NO2/c1-2-13-8(12)5-3-4-6(9)11-7(5)10/h3-4H,2H2,1H3
- InChIKey
- KKYBVLDQTWQETN-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC=C1C(OCC)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E1194
- Product name
- Ethyl 2,6-Dichloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $151
- Updated
- 2025/07/31
- Product number
- E1194
- Product name
- Ethyl 2,6-Dichloronicotinate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $455
- Updated
- 2025/07/31
- Product number
- B124840
- Product name
- Ethyl 2,6-Dichloronicotinate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H58-5-9G
- Product name
- Ethyl 2,6-dichloropyridine-3-carboxylate
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- OR303082
- Product name
- Ethyl2,6-dichloropyridine-3-carboxylate
- Packaging
- 5g
- Price
- $87
- Updated
- 2021/12/16
2,6-Dichloronicotinic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
38496-18-3
64-17-5
58584-86-4
General procedure: 2,6-dichloronicotinic acid (25.5 g, 0.1328 mol) was mixed with ethanol (200 mL) under nitrogen protection and 96% sulfuric acid (1.7 g) was added as catalyst. The reaction mixture was heated to reflux temperature for esterification. Upon completion of the reaction, ethyl 2,6-dichloronicotinate was obtained as a gray solid (24.89 g, 0.1131 mol, 85.2% yield) after conventional post-treatment. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.30 (d, J = 8.1 Hz, 1H), 7.71 (d, J = 8.1 Hz, 1H), 4.33 (q, J = 7.2 Hz, 2H) and 1.30 (t, J = 7.2 Hz, 3H) ppm.
References
[1] Patent: US2015/291629, 2015, A1. Location in patent: Paragraph 0722-0723
[2] Patent: WO2009/150230, 2009, A1. Location in patent: Page/Page column 134
[3] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 65
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4273 - 4288
[5] Patent: US2006/194801, 2006, A1. Location in patent: Page/Page column 38-39
2,6-Dichloronicotinic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Dichloronicotinic acid ethyl ester Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 2,6-Dichloronicotinic acid ethyl ester manufacturers
- Product
- 2,6-Dichloronicotinic acid ethyl ester 58584-86-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-06
- Product
- 2,6-Dichloronicotinic acid ethyl ester 58584-86-4
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2,6-Dichloronicotinic acid ethyl ester 58584-86-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2019-12-17