ChemicalBook > CAS DataBase List > 2,6-Dichloronicotinic acid ethyl ester

2,6-Dichloronicotinic acid ethyl ester

Product Name
2,6-Dichloronicotinic acid ethyl ester
CAS No.
58584-86-4
Chemical Name
2,6-Dichloronicotinic acid ethyl ester
Synonyms
ethyl 2,6-dichloronicotinate;2,6-Dichloronicotinic acid ethyl ester;Ethyl 2,6-dichloropyridine-3-carboxylate;2,6-Dichloropyridin-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester;2,6-dichloro-3-Pyridinecarboxylic acid ethyl ester (9CI ACI);3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester (9CI, ACI)
CBNumber
CB21501258
Molecular Formula
C8H7Cl2NO2
Formula Weight
220.05
MOL File
58584-86-4.mol
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2,6-Dichloronicotinic acid ethyl ester Property

Melting point:
50.0 to 54.0 °C
Boiling point:
286.0±35.0 °C(Predicted)
Density 
1.367±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
-4.48±0.10(Predicted)
color 
White to Light yellow
InChI
InChI=1S/C8H7Cl2NO2/c1-2-13-8(12)5-3-4-6(9)11-7(5)10/h3-4H,2H2,1H3
InChIKey
KKYBVLDQTWQETN-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC=C1C(OCC)=O
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
E1194
Product name
Ethyl 2,6-Dichloronicotinate
Purity
>98.0%(GC)
Packaging
1g
Price
$151
Updated
2025/07/31
TCI Chemical
Product number
E1194
Product name
Ethyl 2,6-Dichloronicotinate
Purity
>98.0%(GC)
Packaging
5g
Price
$455
Updated
2025/07/31
TRC
Product number
B124840
Product name
Ethyl 2,6-Dichloronicotinate
Packaging
100mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-5-9G
Product name
Ethyl 2,6-dichloropyridine-3-carboxylate
Packaging
1g
Price
$61
Updated
2021/12/16
Apolloscientific
Product number
OR303082
Product name
Ethyl2,6-dichloropyridine-3-carboxylate
Packaging
5g
Price
$87
Updated
2021/12/16
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2,6-Dichloronicotinic acid ethyl ester Chemical Properties,Usage,Production

Synthesis

38496-18-3

64-17-5

58584-86-4

General procedure: 2,6-dichloronicotinic acid (25.5 g, 0.1328 mol) was mixed with ethanol (200 mL) under nitrogen protection and 96% sulfuric acid (1.7 g) was added as catalyst. The reaction mixture was heated to reflux temperature for esterification. Upon completion of the reaction, ethyl 2,6-dichloronicotinate was obtained as a gray solid (24.89 g, 0.1131 mol, 85.2% yield) after conventional post-treatment. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.30 (d, J = 8.1 Hz, 1H), 7.71 (d, J = 8.1 Hz, 1H), 4.33 (q, J = 7.2 Hz, 2H) and 1.30 (t, J = 7.2 Hz, 3H) ppm.

References

[1] Patent: US2015/291629, 2015, A1. Location in patent: Paragraph 0722-0723
[2] Patent: WO2009/150230, 2009, A1. Location in patent: Page/Page column 134
[3] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 65
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4273 - 4288
[5] Patent: US2006/194801, 2006, A1. Location in patent: Page/Page column 38-39

2,6-Dichloronicotinic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,6-Dichloronicotinic acid ethyl ester manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2,6-Dichloronicotinic acid ethyl ester 58584-86-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-06-06
Henan Fengda Chemical Co., Ltd
Product
2,6-Dichloronicotinic acid ethyl ester 58584-86-4
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Career Henan Chemical Co
Product
2,6-Dichloronicotinic acid ethyl ester 58584-86-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2019-12-17

58584-86-4, 2,6-Dichloronicotinic acid ethyl esterRelated Search:

Ethyl nitrate ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate 2,4,5,6-TETRACHLORO-NICOTINIC ACID ETHYL ESTER ETHYL 2,5,6-TRICHLORO-4-[(4-METHYLPHENYL)THIO]NICOTINATE 2,6-Dichloronicotinic acid 2,6-Dichloronicotinic acid ethyl ester Methyl 2,6-dichloronicotinate 3,4,5-Trifluorobenzaldehyde

  • 2,6-Dichloronicotinic acid ethyl ester
  • ethyl 2,6-dichloronicotinate
  • Ethyl 2,6-dichloropyridine-3-carboxylate
  • 3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester
  • 3-Pyridinecarboxylic acid, 2,6-dichloro-, ethyl ester (9CI, ACI)
  • 2,6-dichloro-3-Pyridinecarboxylic acid ethyl ester (9CI ACI)
  • 2,6-Dichloropyridin-3-carboxylic acid ethyl ester
  • 58584-86-4
  • pharmacetical