6-Aminonicotinaldehyde
- Product Name
- 6-Aminonicotinaldehyde
- CAS No.
- 69879-22-7
- Chemical Name
- 6-Aminonicotinaldehyde
- Synonyms
- 6-Aminonicotildehyde;6-Aminonicotinaldehyde;Abemaciclib Impurity 32;2-aMino-5-forMylpyridine;6-Aminopyridin-3-carbaldehyde;6-Amino-pyridine-3-carbaldehyde;6-Aminopyridine-3-carboxaldehyde;6-aMino-3-Pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 6-amino-;6-aMinonicotinaldehyde hydrochloride
- CBNumber
- CB21501551
- Molecular Formula
- C6H6N2O
- Formula Weight
- 122.12
- MOL File
- 69879-22-7.mol
6-Aminonicotinaldehyde Property
- Melting point:
- 161℃
- Boiling point:
- 309.0±27.0 °C(Predicted)
- Density
- 1.264±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.78±0.13(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A629030
- Product name
- 6-Aminopyridine-3-carboxaldehyde
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- A629030
- Product name
- 6-Aminopyridine-3-carboxaldehyde
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- A629030
- Product name
- 6-Aminopyridine-3-carboxaldehyde
- Packaging
- 2.5g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 162091
- Product name
- 6-Aminopyridine-3-carboxaldehyde
- Packaging
- 1g
- Price
- $496
- Updated
- 2021/12/16
- Product number
- 122883
- Product name
- 2-Amino-5-formylpyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $710
- Updated
- 2021/12/16
6-Aminonicotinaldehyde Chemical Properties,Usage,Production
Uses
6-Aminopyridine-3-carboxaldehyde is a novel ribonucleotide reductase inhibitor that belongs to the class of metal-binding site affecting ribonucleotide inhibitors that are derivatives of alpa-hetero cyclic carboxaldehyde thiosemicarbazone.
Synthesis
4214-73-7
69879-22-7
General procedure for the synthesis of 2-amino-5-formylpyridine from 2-amino-5-cyanopyridine: To a solution of 2-amino-5-cyanopyridine (10 g, 83.95 mmol, 1 eq.) in tetrahydrofuran (THF, 150 mL) was slowly added lithium aluminum hydride (LAH, 6.37 g, 167.90 mmol, 2 eq.) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 1.5 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated sodium sulfate solution at 0 °C followed by the addition of water (100 mL). The reaction mixture was extracted with ethyl acetate (100 mL x 3). The organic layers were combined, washed with saturated brine (30 mL × 1), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 2-amino-5-formylpyridine (7.50 g, 61.42 mmol, 73.16% yield) as a yellow oil.LCMS (ESI) analysis: m/z [M + H]+ Theoretical value for C6H6N2O was 123; measured value 123; retention time (RT) = 0.099 min.
References
[1] Patent: WO2018/209132, 2018, A1. Location in patent: Paragraph 0458; 0489
[2] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 292 - 300
[3] Patent: US2009/143420, 2009, A1. Location in patent: Page/Page column 7
[4] Patent: EP1724263, 2006, A1. Location in patent: Page/Page column 55
[5] Patent: EP3305785, 2018, A1. Location in patent: Paragraph 0177; 0178
6-Aminonicotinaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Aminonicotinaldehyde manufacturers
- Product
- 6-Aminonicotinaldehyde 69879-22-7
- Price
- US $4000.00-3850.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 5mt
- Release date
- 2025-06-08
- Product
- 6-Aminonicotinaldehyde 69879-22-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02
- Product
- 6-Aminonicotinaldehyde 69879-22-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-27