Prinaberel

ChemicalBook > CAS DataBase List > Prinaberel

Product Name: Prinaberel
CAS No.: 524684-52-4
Chemical Name: Prinaberel
Synonyms: ERB 041;PRINABEREL;WAY-202041;Prinaberel (ERB 041);2-(3-Fluoro-4-hydroxyphenyl)- 7-vinylbenzoxazol-5-ol;7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol;2-(3-Fluoro-4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol;5-Benzoxazolol, 7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-;2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol
CBNumber: CB21509128
Molecular Formula: C15H10FNO3
Formula Weight: 271.24
MOL File: 524684-52-4.mol

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Prinaberel Property

Melting point:: 250-252 ºC
Boiling point:: 451.6±45.0 °C(Predicted)
Density: 1.413
storage temp.: room temp
solubility: DMSO: ≥25mg/mL
form: powder
pka: 7.50±0.20(Predicted)
color: white to tan
InChIKey: MQIMZDXIAHJKQP-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0183
Product name: ERB-041
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $147
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0183
Product name: ERB-041
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $547
Updated: 2024/03/01

Cayman Chemical

Product number: 28737
Product name: ERB 041
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 28737
Product name: ERB 041
Packaging: 5mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 28737
Product name: ERB 041
Packaging: 10mg
Price: $155
Updated: 2024/03/01

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Prinaberel Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

Uses

Prinaberel is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

Biological Activity

ERB-041 is a potent, selective estrogen ERβ receptor agonist (IC50 ERβ: 5.4 nM; > 200-fold selective over ERα). ERβ plays a minor role in mediating estrogen action in the uterus, the hypothalamus/pituitary, the skeleton, and other classic estrogen target tissues. However, a clear role for ERβ has been established in the ovary, cardiovascular system, and brain as well as in animal models of inflammation including arthritis, endometriosis, inflammatory bowel disease, and sepsis. There is increasing interest in finding ERβ agonists for potential use in a variety of clinical applications without triggering classic estrogenic side effects.

storage

Store at -20°C

Prinaberel Preparation Products And Raw materials

Raw materials

Preparation Products

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Prinaberel Suppliers

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View Lastest Price from Prinaberel manufacturers

Career Henan Chemical Co

Product: Prinaberel 524684-52-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-18

524684-52-4, PrinaberelRelated Search:

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ERB 041

2-(3-Fluoro-4-hydroxyphenyl)- 7-vinylbenzoxazol-5-ol

7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol

PRINABEREL

2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol

Prinaberel (ERB 041)

WAY-202041

5-Benzoxazolol, 7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-

2-(3-Fluoro-4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol

524684-52-4

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