6-bromo-2-chloroquinoxaline
- Product Name
- 6-bromo-2-chloroquinoxaline
- CAS No.
- 55687-02-0
- Chemical Name
- 6-bromo-2-chloroquinoxaline
- Synonyms
- 6-bromo-2-chloroquinoxaline;Quinoxaline, 6-bromo-2-chloro-
- CBNumber
- CB21515820
- Molecular Formula
- C8H4BrClN2
- Formula Weight
- 243.49
- MOL File
- 55687-02-0.mol
6-bromo-2-chloroquinoxaline Property
- Melting point:
- 150-152.5 °C
- Boiling point:
- 312.5±37.0 °C(Predicted)
- Density
- 1.762±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.46±0.30(Predicted)
- Appearance
- Gray to brown Solid
- InChI
- InChI=1S/C8H4BrClN2/c9-5-1-2-6-7(3-5)11-4-8(10)12-6/h1-4H
- InChIKey
- XDJDRCGDVKTDHY-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(Br)=CC=2)N=CC=1Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B684843
- Product name
- 6-Bromo-2-chloroquinoxaline
- Packaging
- 1g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- 073181
- Product name
- 6-Bromo-2-chloroquinoxaline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- 073181
- Product name
- 6-Bromo-2-chloroquinoxaline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $231
- Updated
- 2021/12/16
- Product number
- FB42250
- Product name
- 6-Bromo-2-chloroquinoxaline
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB42250
- Product name
- 6-Bromo-2-chloroquinoxaline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
6-bromo-2-chloroquinoxaline Chemical Properties,Usage,Production
Uses
6-Bromo-2-chloroquinoxaline is a quinoline derivative that can be used as a pharmaceutical intermediate.
Application
6-Bromo-2-chloroquinoxaline can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Preparation
From 6-bromo-2-hydroxyquinoxaline, tetra-n-butylammonium chloride and phosphorus pentoxide to toluene to react to obtain 6-bromo-2-chloroquinoxaline.
Synthesis
55687-34-8
55687-02-0
C. Synthesis of 6-bromo-2-chloroquinoxaline. 6-Bromoquinoxalin-2(1H)-one (255 mg, 1.1 mmol) from Step B was added to a reaction flask containing phosphorus trichloride (3.4 ml, 36.5 mmol). The reaction mixture was stirred and reacted at 60 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by slowly pouring into ice water. The precipitated solid was collected by filtration and dried to give the target product 6-bromo-2-chloroquinoxaline (239 mg, 87% yield).
References
[1] ChemMedChem, 2014, vol. 9, # 7, p. 1378 - 1386
[2] Patent: WO2009/39134, 2009, A1. Location in patent: Page/Page column 185
[3] Patent: WO2016/199943, 2016, A1. Location in patent: Page/Page column 0288
[4] Patent: WO2010/136755, 2010, A1. Location in patent: Page/Page column 46; 47
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 6,7
6-bromo-2-chloroquinoxaline Preparation Products And Raw materials
Raw materials
Preparation Products
6-bromo-2-chloroquinoxaline Suppliers
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View Lastest Price from 6-bromo-2-chloroquinoxaline manufacturers
- Product
- 6-bromo-2-chloroquinoxaline 55687-02-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-10