5-AMINOTHIAZOLE HCL

5-AMINOTHIAZOLE HCL Property

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

Appearance

White to light yellow Solid

InChI

InChI=1S/C3H4N2S.ClH/c4-3-1-5-2-6-3;/h1-2H,4H2;1H

InChIKey

WFJPRXNQDKBTPT-UHFFFAOYSA-N

SMILES

S1C(N)=CN=C1.Cl

Safety

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

HS Code 

2934100090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

5-AMINOTHIAZOLE HCL Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 5-aminothiazole hydrochloride from tert-butyl thiazole-5-carbamate: To a stirred solution of tert-butyl thiazole-5-carbamate (379, 300 mg, 1.5 mmol) in methanol (5 mL), protected by argon at 0°C, a 1,4-dioxane solution (5 mL) in 4N HCl was slowly added. The reaction mixture was gradually warmed up to room temperature and stirring was continued for 3 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the volatile solvent was removed under reduced pressure to give the crude product. The crude product was washed with n-pentane (2 × 5 mL) and subsequently dried under reduced pressure to afford 5-aminothiazole hydrochloride (380, 150 mg, HCl salt) as a light yellow solid.TLC conditions: 50% ethyl acetate/hexane (Rf 0.1); 1H-NMR (DMSO-d6, 500 MHz) data: δ 9.10 (s, 1H), 7.22 (s. 1H).

References

[1] Patent: WO2007/71955, 2007, A1. Location in patent: Page/Page column 47
[2] Patent: WO2014/41175, 2014, A1. Location in patent: Page/Page column 55
[3] Patent: WO2015/138895, 2015, A1. Location in patent: Paragraph 000310