piperlonguminine

ChemicalBook > CAS DataBase List > piperlonguminine

Product Name: piperlonguminine
CAS No.: 5950-12-9
Chemical Name: piperlonguminine
Synonyms: MEXE;mexedrone;Piperlonguminin;Piperlonguminine;N-Isobutylpiperamide;Mexedrone MEXE MDPHP BK-2CB;Piperlonguminine, 10 mM in DMSO;Mexedrone Cas no.: 5950-12-9 White crystal 99%;5-benzo[1,3]dioxol-5-yl-N-(2-methylpropyl)penta-2,4-dienamide;(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-isobutyl-penta-2,4-dienamide
CBNumber: CB21562460
Molecular Formula: C16H19NO3
Formula Weight: 273.33
MOL File: 5950-12-9.mol

Less

piperlonguminine Property

Melting point:: l66-8°C
storage temp.: Store at -20°C
solubility: ≤3mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid
color: White to off-white
InChI: InChI=1S/C16H19NO3/c1-12(2)10-17-16(18)6-4-3-5-13-7-8-14-15(9-13)20-11-19-14/h3-9,12H,10-11H2,1-2H3,(H,17,18)/b5-3+,6-4+
InChIKey: WHAAPCGHVWVUEX-GGWOSOGESA-N
SMILES: C(NCC(C)C)(=O)/C=C/C=C/C1=CC=C2OCOC2=C1

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 9001155
Product name: Piperlonguminine
Purity: ≥98%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 9001155
Product name: Piperlonguminine
Purity: ≥98%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 9001155
Product name: Piperlonguminine
Purity: ≥98%
Packaging: 25mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 9001155
Product name: Piperlonguminine
Purity: ≥98%
Packaging: 50mg
Price: $210
Updated: 2024/03/01

ApexBio Technology

Product number: C3508
Product name: Piperlonguminine
Packaging: 50mg
Price: $222
Updated: 2021/12/16

Less

piperlonguminine Chemical Properties,Usage,Production

Description

This amide alkaloid also occurs in the roots of Piper longum and yields colourless needles from EtOH. The ultraviolet spectrum exhibits absorption maxima at 245,256, 307 and 340 mil. The side chain is doubly unsaturated and on catalytic hydrogenation, the base furnishes the tetrahydro derivative, m.p. 66°C.

Description

Piperlonguminine is an alkaloid amide from species of the genus Piper, a plant used in traditional medicine that demonstrates antifungal, anticancer, antihyperlipidemic, and anti-inflammatory properties. Piperlonguminine (3-12.5 μM) has been shown to dose dependently decrease expression of amyloid precursor protein and amyloid-β peptide in human neuroblastoma cells, suggesting it may have implication in treating Alzheimer’s disease.

Definition

ChEBI: (E,E)-Piperlonguminine is a member of benzodioxoles.

Biological Activity

Piperlonguminine is an alkaloid amide isolated from the Piper species. It has a wide range of biological properties including anti-inflammatory, anti-tumour, neuroprotective, anti-platelet, anti-melanogenic, anti-fungal and antibacterial activities. In addition, its derivative piperlonguminine acid has Antihyperlipidemic activity.

in vitro

in a previous study, piperlonguminine was discovered to inhibit melanin production in melanoma b16 cells stimulated with α-msh, 3-isobutyl-1-methylxanthine or protoporphyrin ix, where piperlonguminine showed stronger depigmenting efficacy. however, piperlonguminine could not alter1-oleoyl-2-acetyl-sn-glycerol-induced melanogenesis and could not affect protein kinase c-mediated melanin production. in additioin, piperlonguminine was not able to inhibit the catalytic activity of cell-free tyrosinase from melanoma b16 cells, and such effect was attributed to the inhibitory action of piperlonguminine on α-msh-induced signaling via camp to the camp responsive element binding protein [1].

in vivo

in vivo, rats were subjected to middle cerebral artery occlusion for 1h, followed by reperfusion for 23 h. the results showed that the intraperitoneal injection of piperlonguminine pe at 2.4 mg/kg was able to produce a significant neuroprotective potential in rats with cerebral ischemia. in addition, piperlonguminine could attenuate the neurological deficit scores, brain infarct volume and brain water content, and could inhibit the activation of nf-κb and mapk [2].

References

Chatterjee, Dutta., Tetrahedron Lett., 1797 (1966)
Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)

piperlonguminine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

piperlonguminine Suppliers

China 78 India 1 United States 7 USA 1 Global 87

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@163.com
Country: China
ProdList: 283
Advantage: 58

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 400-186-5138 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1010
Advantage: 58

Cheng Du Pufeide Biotechnology Co., Ltd.

Tel: 028-82610909 13388174823
Fax: 8171-1798
Email: scglp@glp-china.com
Country: China
ProdList: 1064
Advantage: 58

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9349
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Hangzhou Zhenghan Biological Technology Co., Ltd.

Tel: +8618968058020
Fax: 0571-88781753
Email: zhenghanbio@qq.com
Country: China
ProdList: 28
Advantage: 56

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 4108
Advantage: 58

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-85370565-229 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 8915
Advantage: 60

Shanghai Standard Technology Co.,Ltd.

Tel: 021-021-57127007-6622-6622 17621252073
Fax: +86 (21) 5132-0077
Email: luzh@nature-standard.com
Country: China
ProdList: 3021
Advantage: 58

Henan Alfachem Co.,Ltd.

Tel: 0371-0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 10010
Advantage: 58

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel
Country: China
ProdList: 12003
Advantage: 58

sgtlifesciences pvt ltd

Tel: +8617013299288
Email: dj@sgtlifesciences.com
Country: China
ProdList: 12373
Advantage: 58

Wuhan Monad Medicine Tech Co.,LTD

Tel: 02768782018 18771942761
Email: sales01@whmonad.com
Country: CHINA
ProdList: 979
Advantage: 58

Hebei Zhanyao Biotechnology Co. Ltd

Tel: 15369953316 +8615369953316
Email: admin@zhanyaobio.com
Country: China
ProdList: 2123
Advantage: 58

Hebei Runbin Biotechnology Co. LTD

Tel: 13180553332
Email: 2179877681@qq.com
Country: CHINA
ProdList: 990
Advantage: 58

Hebei Bonster Technology Co.,Limited

Tel: +8613315996897
Fax: 0086-13315996897
Email: bsterltd.wendy@gmail.com
Country: China
ProdList: 792
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Chengdu Alfa Biotechnology Co.,Ltd.

Tel: 028-028-85142057 19983342022
Fax: 028-85142057
Email: 3005359975@qq.com
Country: China
ProdList: 1970
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 1388
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81024372 15029046529
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10010
Advantage: 58

Shanghai Bohu Biotechnology Co., LTD

Tel: 021-57763112 13585886131
Email: 3004987436@qq.com
Country: China
ProdList: 9693
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7974
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10524
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: zhouzz@univ-bio.com
Country: China
ProdList: 24998
Advantage: 58

Jiangsu Yongjian Pharmaceutical Technology Co., Ltd

Tel: 17701422015
Email: 3582572959@qq.com
Country: China
ProdList: 697
Advantage: 58

Chengdu Push Bio-Technology Co., Ltd.

Tel: 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 9209
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13341702378
Email: 190129269@qq.com
Country: China
ProdList: 9136
Advantage: 58

NINGBO JL NEW MATERIAL CO.,LTD

Tel: 0574-88552218 18969899212
Email: sales@jlbio-tech.cn
Country: China
ProdList: 731
Advantage: 58

Shanghai Yingxin Laboratory Equipment Co., Ltd.

Tel: 021-021-59178156 17002132182
Email: 3146474380@qq.com
Country: China
ProdList: 11603
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Aikon International Limited

Tel: 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 10715
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 30016
Advantage: 58

Naturewill Biotechnology Co., Ltd.

Tel: 028-82632533 18113192475
Email: 3157321941@qq.com
Country: China
ProdList: 5003
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Hubei Enxing Biotechnology Co., Ltd

Tel: 16621771607
Email: exbio_tech@163.com
Country: China
ProdList: 8189
Advantage: 58

Shanghai Guchen Biotechnology Co., LTD

Tel: 021-34675735 19147740836
Email: 1986399151@qq.com
Country: China
ProdList: 9844
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6827
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: rose.shi@synzest.com
Country: China
ProdList: 6210
Advantage: 58

Wuhan Huangzhen Biochemical Co., Ltd

Tel: 13795480948 13795480948
Email: 3450865996@qq.com
Country: China
ProdList: 4958
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9266
Advantage: 58

Hubei CuiRan Biotechnology Co., Ltd.

Tel: 18162791556
Email: 3152548389@qq.com
Country: China
ProdList: 4351
Advantage: 58

SHANGHAI ZZBIO CO., LTD.

Tel: 15102117276 19921389125
Email: tech@zzbioco.com
Country: China
ProdList: 12065
Advantage: 58

Shanghai Fuorain BioTech Co., Ltd

Tel: 18672534757
Email: xiaoxue.hu@fuorain.cn
Country: China
ProdList: 1905
Advantage: 58

RENI Pharmaceutical Technology Co., Ltd

Tel: 028-87865381 18108190480
Email: 2881944542@qq.com
Country: China
ProdList: 3303
Advantage: 58

Mensura Group Limited

Tel: 18109034517
Fax: 028-87362290
Email: 18109034517@163.com
Country: China
ProdList: 2898
Advantage: 58

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 73043
Advantage: 58

Less

View Lastest Price from piperlonguminine manufacturers

Hebei Dangtong Import and export Co LTD

Product: piperlonguminine 5950-12-9
Price: US $24.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 300tons
Release date: 2024-09-12

Wuhan Boyuan Import & Export Co., LTD

Product: Piperlonguminine 5950-12-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000tons
Release date: 2023-07-14

Henan Bao Enluo International TradeCo.，LTD

Product: piperlonguminine 5950-12-9
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-06-19

5950-12-9, piperlonguminineRelated Search:

(4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one alpha-Cyperone alpha-Terpineol hydroxygenkwanin beta-Sitosterol Artemether beta-Eudesmol 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one BB-22 1-(5-Fluoro-pentyl)-1H-indole-3-carboxylic acid (1-carbaMoyl-2-Methyl-propyl)-aMide MMB-2201 THJ-018 4-emc 4-CPRC ADB-FUBINACA (E/Z)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid Methyl ester ADB-CHMINACA AMB-CHMINACA

MEXE

Mexedrone MEXE MDPHP BK-2CB

Mexedrone Cas no.: 5950-12-9 White crystal 99%

Mexedrone Crystal , mexe Pharmaceutical Intermediates CAS 5950-12-9

5-benzo[1,3]dioxol-5-yl-N-(2-methylpropyl)penta-2,4-dienamide

Piperlonguminine

5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-2E,4E-pentadienamide

mexedrone

N-Isobutylpiperamide

(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-isobutyl-penta-2,4-dienamide

2,4-Pentadienamide, 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (2E,4E)-

TIANFU-CHEM CAS:5950-12-9 5-benzo[1,3]dioxol-5-yl-N-(2-methylpropyl)penta-2,4-dienamide

Piperlonguminin

amide,Inhibitor,inhibit,alkaloid,anti-melanogenic,Bacterial,antibacterial,neuroprotective,antifungal,Piperlonguminine,anti-platelet,Fungal,antitumor,anti-inflammatory,Piper

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-N-isobutylpenta-2,4-dienamide

Piperlonguminine, 10 mM in DMSO

5950-12-9

5650-12-9

for pharmaceutical intermediate