ZONISAMIDE-13C2-15N
- Product Name
- ZONISAMIDE-13C2-15N
- CAS No.
- 1188265-58-8
- Chemical Name
- ZONISAMIDE-13C2-15N
- Synonyms
- ZONISAMIDE-13C2-15N;13C2,15N]-Zonisamide
- CBNumber
- CB2156257
- Molecular Formula
- C8H8N2O3S
- Formula Weight
- 215.25
- MOL File
- Mol file
ZONISAMIDE-13C2-15N Property
- Melting point:
- 158 - 160°C
- storage temp.
- Refrigerator
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Light Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 28807
- Product name
- Zonisamide-13C2,15N
- Packaging
- 1mg
- Price
- $396
- Updated
- 2024/03/01
- Product number
- Z700003
- Product name
- Zonisamide-13C2-15N
- Packaging
- 10mg
- Price
- $1980
- Updated
- 2021/12/16
- Product number
- CN17154
- Product name
- Zonisamide-13C2,15N
- Packaging
- 5mg
- Price
- $2900
- Updated
- 2021/12/16
- Product number
- CN100165
- Product name
- Zonisamid2-15C2-15N
- Packaging
- 1mg
- Price
- $475
- Updated
- 2021/12/16
- Product number
- CN17154
- Product name
- Zonisamide-13C2,15N
- Packaging
- 1mg
- Price
- $1750
- Updated
- 2021/12/16
ZONISAMIDE-13C2-15N Chemical Properties,Usage,Production
Description
Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent. It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml. In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium current. Zonisamide inhibits H. pylori recombinant carbonic anhydrase (CA) and the human CA isoforms I, II, and V with Ki values of 218, 56, 35, and 21 nM, respectively. In mice, it has anticonvulsant activity against maximal electroshock seizure (MES) and pentylenetetrazole-induced maximal, but not minimal, seizures (ED50s = 19.6, 9.3, and >500 mg/kg, respectively). Zonisamide (40 mg/kg, p.o.) prevents MPTP-induced decreases in the levels of dopamine , but not homovanillic acid (HVA; ) or dihydroxyphenyl acetic acid (DOPAC; ), and increases MPTP-induced decreases in the dopamine turnover rate in mouse striatum in a model of Parkinson''s disease. Formulations containing zonisamide have been used in the treatment of partial seizures in adults with epilepsy.
Uses
Zonisamide-13C2-15N is the labeled analogue of Zonisamide (Z700000), a sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant.
ZONISAMIDE-13C2-15N Preparation Products And Raw materials
Raw materials
Preparation Products
ZONISAMIDE-13C2-15N Suppliers
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