N-Carbobenzoxy-L-homoserine
- Product Name
- N-Carbobenzoxy-L-homoserine
- CAS No.
- 35677-88-4
- Chemical Name
- N-Carbobenzoxy-L-homoserine
- Synonyms
- Cbz-hse-OH;Cbz-Homoserine;Cbz-L-Homoserine;N-Carbobenzoxy-L-homoserine;N-(Benzyloxycarbonyl)-L-homoserine;Cbz-HoMoser Cbz-HoMoserine Cbz-Hse;(S)-benzyl 2-amino-4-hydroxybutanoate;L-HoMoserine, N-[(phenylMethoxy)carbonyl]-;2-CarboxyaMino-4-hydroxybutyric acid, N-benzyl Ester;(2S)-4-hydroxy-2-(phenylmethoxycarbonylamino)butanoic
- CBNumber
- CB21568730
- Molecular Formula
- C12H15NO5
- Formula Weight
- 253.25
- MOL File
- 35677-88-4.mol
N-Carbobenzoxy-L-homoserine Property
- Melting point:
- 100-101 °C
- Boiling point:
- 519.9±50.0 °C(Predicted)
- Density
- 1.311
- storage temp.
- 2-8°C
- pka
- 3.85±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- optical activity
- Consistent with structure
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C176580
- Product name
- N-Carbobenzoxy-L-homoserine
- Packaging
- 1g
- Price
- $1055
- Updated
- 2021/12/16
- Product number
- J96270
- Product name
- Cbz-L-Homoserine
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- CS-0062253
- Product name
- N-Carbobenzoxy-L-homoserine
- Packaging
- 1g
- Price
- $58
- Updated
- 2021/12/16
- Product number
- FC19701
- Product name
- N-Cbz-L-homoserine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- W5720
- Product name
- Cbz-L-Homoserine
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
N-Carbobenzoxy-L-homoserine Chemical Properties,Usage,Production
Uses
N-Carbobenzoxy-L-homoserine (cas# 35677-88-4) is a compound useful in organic synthesis.
Synthesis
672-15-1
501-53-1
35677-88-4
General procedure for the synthesis of (S)-2-(((benzyloxy)carbonyl)amino)-4-hydroxybutyric acid from L-homoserine and benzyl chloroformate: L-homoserine (4.76 g, 40 mmol) was dissolved in a solvent mixture of H2O (200 mL) and 1,4-dioxane (50 mL). To this solution was added NaHCO3 (13.44 g, 160 mmol), followed by slow dropwise addition of benzyl chloroformate (6.76 mL, 48 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was washed twice with ethyl acetate (EA). The aqueous layer was neutralized to pH 2 with 4 mol/L HCl solution and then extracted with EtOAc. The organic layers were combined, washed sequentially with water and brine, dried over anhydrous Na2SO4 and concentrated to dryness under reduced pressure. The resulting crude product (8.86 g, 35 mmol, 87.5% yield) was used directly in the next reaction without further purification.
References
[1] Synthetic Communications, 1988, vol. 18, # 14, p. 1715 - 1722
[2] Journal of Organic Chemistry, 2003, vol. 68, # 7, p. 2668 - 2672
[3] Tetrahedron Letters, 2017, vol. 58, # 42, p. 3970 - 3973
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9133 - 9153
[5] Journal of Organic Chemistry, 1986, vol. 51, # 26, p. 5047 - 5050
N-Carbobenzoxy-L-homoserine Preparation Products And Raw materials
Raw materials
Preparation Products
N-Carbobenzoxy-L-homoserine Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from N-Carbobenzoxy-L-homoserine manufacturers
- Product
- N-Carbobenzoxy-L-homoserine 35677-88-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09